Chapter 7. Sporotrichosis, the Fungal Disease Caused by Members of the Sporothrix Genus


Ximena Esquivias-Varela, Juan Mauricio Ibarra-Chavira, Laura C. García-Carnero, Manuela Gómez-Gaviria,
Ana Paulina Vargas-Macías and Héctor Manuel Mora-Montes
Department of Biology, Universidad de Guanajuato, Guanajuato, Mexico

Part of the book: The Book of Fungal Pathogens


Sporotrichosis is a worldwide distributed cutaneous or subcutaneous mycosis due to implantation. Once thought to be caused by a single species, Sporothrix schenckii, it is now well established that the etiological agents are cryptic thermodimorphic fungi, taxonomically classified within the Sporothrix pathogenic clade. Currently, infections caused by S. schenckii, Sporothrix brasiliensis, and Sporothrix globosa are the most frequently reported, each species with a different virulence degree. In addition, there are recent reports that establish the emergence of antifungal resistant strains of Sporothrix species. These organisms live in decomposition plant biomass and can infect not only humans but wild and domestic animals. Both ecological niches can be the source of the infective organisms, thus sporotrichosisis is considered a sapronosis and a zoonosis. Despite most of the cases being restricted to the subcutaneous cellular tissue, being some of them self-limited, atypical cases in immunosuppressed patients are reported, where deep-seated organs are affected, such as lungs and the central nervous system. Treatment options are variable, depending on the fungal species, the clinical presentation, and the patient’s immunological status, for which a well-timed diagnosis is important. In this chapter, we discuss the biological aspects of the members of the Sporothrix pathogenic clade, and clinical and epidemiological aspects of the disease, including new alternatives for diagnosis and treatment.

Keywords: subcutaneous infection, virulence factors, antifungal drugs, immune sensing, zoonosis, sapronosis


[1] Lopes-Bezerra, L.M., Mora-Montes, H.M., Zhang, Y., Nino-Vega, G., Rodrigues, A.M., de Camargo,
Z.P., de Hoog, S. Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable
disease and on emerging etiological agents. Med Mycol 2018, 56, 126-143.
[2] Barros, M.B.d.L., de Almeida Paes, R., Schubach, A.O. Sporothrix schenckii and sporotrichosis.
Clin Microbiol Rev 2011, 24, 633-654.
[3] Chakrabarti, A., Bonifaz, A., Gutierrez-Galhardo, M.C., Mochizuki, T., Li, S.
Global epidemiology of sporotrichosis. Med Mycol 2015, 53, 3-14,
[4] Zurabian, R., Hernández Hernández, F. Esporotricosis: la micosis subcutánea más frecuente en México
[Sporotrichosis: the most frequent subcutaneous mycosis in Mexico].
Rev Fac Med (Méx) 2019, 62, 48-55.
[5] Zhang, Y., Hagen, F., Stielow, B., Rodrigues, A.M., Samerpitak, K., Zhou, X., Feng, P., Yang, L.,
Chen, M., Deng, S., et al. Phylogeography and evolutionary patterns in Sporothrix spanning more than
14 000 human and animal case reports. Persoonia 2015, 35, 1-20.
[6] Marimon, R., Cano, J., Gené, J., Sutton, D.A., Kawasaki, M., Guarro, J. Sporothrix brasiliensis, S.
globosa, and S. mexicana, three new Sporothrix species of clinical interest.
J Clin Microbiol 2007, 45, 3198-3206.
[7] de Beer, Z.W., Duong, T.A., Wingfield, M.J. The divorce of Sporothrix and Ophiostoma: solution to a
problematic relationship. Stud Mycol 2016, 83, 165-191.
[8] López-Romero, E., Reyes-Montes Mdel, R., Pérez-Torres, A., Ruiz-Baca, E., Villagómez-Castro, J.C.,
Mora-Montes, H.M., Flores-Carreón, A., Toriello, C. Sporothrix schenckii complex and sporotrichosis,
an emerging health problem. Future Microbiol 2011, 6, 85-102.
[9] Rodrigues, A.M., de Hoog, G.S., de Camargo, Z.P. Sporothrix species causing outbreaks in animals
and humans driven by animal-animal transmission. PLoS Pathog 2016, 12, e1005638.
[10] dos Santos, G.M.P., Borba-Santos, L.P., Vila, T., Ferreira Gremião, I.D., Pereira, S.A., De Souza, W.,
Rozental, S. Sporothrix spp. biofilms impact in the zoonotic transmission route: feline claws associated
biofilms, itraconazole tolerance, and potential repurposing for miltefosine. Pathogens 2022, 11, 206.
[11] Paiva, M.T., de Oliveira, C.S.F., Nicolino, R.R., Bastos, C.V., Lecca, L.O., de Azevedo, M.I., Keller,
K.M., Salvato, L.A., Brandão, S.T., de Oliveira, H.M.R., Morais, M.H.F., Ecco, R., Lech, A.J.Z.,
Haddad, J.P.A., de Magalhães Soares, D.F. Spatial association between sporotrichosis in cats and in
human during a Brazilian epidemics. Preventive veterinary medicine 2020, 183, 105125.
[12] Huang, M., Ma, Z., Zhou, X. Comparative genomic data provide new insight on the evolution of
pathogenicity in Sporothrix species. Front Microbiol 2020, 11, 565439.
[13] Arrillaga-Moncrieff, I., Capilla, J., Mayayo, E., Marimon, R., Mariné, M., Gené, J., Cano, J., Guarro,
J. Different virulence levels of the species of Sporothrix in a murine model.
Clin Microbiol Infect 2009, 15, 651-655.
[14] Lozoya-Pérez, N.E., Clavijo-Giraldo, D.M., Martínez-Duncker, I., García-Carnero, L.C., López Ramírez,
L.A., Niño-Vega, G.A., Mora-Montes, H.M. Influences of the Culturing Media in the
Virulence and Cell Wall of Sporothrix schenckii, Sporothrix brasiliensis, and
Sporothrix globosa. J Fungi (Basel) 2020, 6(4):323.
[15] Nesseler, A., Schauerte, N., Geiger, C., Kaerger, K., Walther, G., Kurzai, O., Eisenberg, T. Sporothrix
humicola (Ascomycota: Ophiostomatales) – A soil-borne fungus with pathogenic potential in the
eastern quoll (Dasyurus viverrinus). Medical mycology case reports 2019, 25, 39-44.
[16] Ventura-Flores, R., Guzman-velasquez, J.M., Tarrillo-Dávila, M.Á. Esporotricosis: una enfermedad
ocupacional y desatendida [Sporotrichosis: an occupational and neglected disease].
Rev Cubana Salud Pública 2018, 44, e1237.
[17] Zhao, M.D., Zhou, X., Liu, T.T., Yang, Z.B. Morphological and physiological comparison of taxa
comprising the Sporothrix schenckii complex. Journal of Zhejiang University.
Science. B 2015, 16, 940-947.
[18] Mora-Montes, H.M., Dantas Ada, S., Trujillo-Esquivel, E., de Souza Baptista, A.R., Lopes-Bezerra,
L.M. Current progress in the biology of members of the Sporothrix schenckii complex following the
genomic era. FEMS Yeast Res 2015, 15.
[19] Lopes-Bezerra, L.M., Walker, L.A., Nino-Vega, G., Mora-Montes, H.M., Neves, G.W.P., Villalobos Duno,
H., Barreto, L., Garcia, K., Franco, B., Martinez-Alvarez, J.A., et al. Cell walls of the dimorphic
fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and
sloughing of extensive and intact layers. PLoS neglected tropical diseases 2018, 12, e0006169.
[20] Martinez-Alvarez, J.A., Perez-Garcia, L.A., Mellado-Mojica, E., Lopez, M.G., Martinez-Duncker, I.,
Lopes-Bezerra, L.M., Mora-Montes, H.M. Sporothrix schenckii sensu stricto and Sporothrix
brasiliensis are differentially recognized by human peripheral blood
mononuclear cells. Front Microbiol 2017, 8, 843.
[21] Villalobos-Duno, H.L., Barreto, L.A., Alvarez-Aular, A., Mora-Montes, H.M., Lozoya-Perez, N.E.,
Franco, B., Lopes-Bezerra, L.M., Nino-Vega, G.A. Comparison of cell wall polysaccharide
composition and structure between strains of Sporothrix schenckii and Sporothrix brasiliensis.
Front Microbiol 2021, 12, 726958.
[22] Teixeira Mde, M., Rodrigues, A.M., Tsui, C.K., de Almeida, L.G., Van Diepeningen, A.D., van den
Ende, B.G., Fernandes, G.F., Kano, R., Hamelin, R.C., Lopes-Bezerra, L.M., et al. Asexual propagation
of a virulent clone complex in a human and feline outbreak of sporotrichosis.
Eukaryotic cell 2015, 14, 158-169.
[23] Trujillo-Esquivel, E., Martinez-Alvarez, J.A., Clavijo-Giraldo, D.M., Hernandez, N.V.,
Flores Martinez, A., Ponce-Noyola, P., Mora-Montes, H.M. The Sporothrix schenckii gene encoding for the
ribosomal protein L6 has constitutive and stable expression and works as an endogenous control in
gene expression analysis. Front Microbiol 2017, 8, 1676.
[24] Mendoza, M., Díaz, A.M., Hung, M.B., Zambrano, E.A., Díaz, E., De Albornoz, M.C. Production of
culture filtrates of Sporothrix schenckii in diverse culture media. Med Mycol 2002, 40, 447-454.
[25] García-Carnero, L.C., Salinas-Marín, R., Lozoya-Pérez, N.E., Wrobel, K., Wrobel, K.,
Martínez Duncker, I., Niño-Vega, G.A., Mora-Montes, H.M. The heat shock protein 60 and Pap1 participate in
the Sporothrixschenckii-host interaction. J Fungi (Basel) 2021, 7, 960.
[26] Ramírez-Soto, M.C., Aguilar-Ancori, E.G., Tirado-Sánchez, A., Bonifaz, A. Ecological determinants
of sporotrichosis etiological agents. J Fungi (Basel) 2018, 4, 95.
[27] Pasarell, L., R., M.M. Viability of fungal cultures maintained at
-70 degrees C. J Clin Microbiol 1992, 30, 1000-1004.
[28] Steenbergen, J.N., Nosanchuk, J.D., Malliaris, S.D., Casadevall, A. Interaction of Blastomyces
dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii.
Infect Immunity 2004, 72, 3478-3488.
[29] Chaturvedi, V.P., Randhawa, H.S., Chaturvedi, S., Khan, Z.U. In vitro interactions between
Blastomyces dermatitidis and other zoopathogenic fungi. Can J Microbiol 1988, 34, 897-900.
[30] Hogan, L.H., Klein, B.S., Levitz, S.M. Virulence factors of medically important fungi.
Clin Microbiol Rev 1996, 9, 469-488.
[31] de Albornoz, M.B., Mendoza, M., de Torres, E.D. Growth temperatures of isolates of Sporothrix
schenckii from disseminated and fixed cutaneous lesions of sporotrichosis.
Mycopathologia 1986, 95, 81-83.
[32] Romero-Martinez, R., Wheeler, M., Guerrero-Plata, A., Rico, G., Torres-Guerrero, H. Biosynthesis
and functions of melanin in Sporothrix schenckii. Infect Immunity 2000, 68, 3696-3703.
[33] Almeida-Paes, R., Frases, S., Araújo, G.d.S., de Oliveira, M.M.E., Gerfen, G.J., Nosanchuk, J.D.,
Zancopé-Oliveira, R.M. Biosynthesis and functions of a melanoid pigment produced by species of the
Sporothrix complex in the presence of L-tyrosine. Appl Environ Microbiol 2012, 78, 8623-8630.
[34] Morris-Jones, R., Youngchim, S., Gomez, B.L., Aisen, P., Hay, R.J., Nosanchuk, J.D., Casadevall, A.,
Hamilton, A.J. Synthesis of melanin-like pigments by Sporothrix schenckii in vitro and during
mammalian infection. Infect Immunity 2003, 71, 4026-4033.
[35] Lima, O.C., Figueiredo, C.C., Pereira, B.A., Coelho, M.G., Morandi, V., Lopes-Bezerra, L.M.
Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins.
Braz J Med Biol Res 1999, 32, 651-657.
[36] Sgarbi, D.B., da Silva, A.J., Carlos, I.Z., Silva, C.L., Angluster, J., Alviano, C.S. Isolation of ergosterol
peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii. Mycopathologia
1997, 139, 9-14.
[37] Carlos, I.Z., Sassá, M.F., da Graça Sgarbi, D.B., Placeres, M.C., Maia, D.C. Current research on the
immune response to experimental sporotrichosis. Mycopathologia 2009, 168, 1-10.
[38] Lei, P.C., Yoshiike, T., Ogawa, H. Effects of proteinase inhibitors on the cutaneous lesion of Sporothrix
schenckii inoculated hairless mice. Mycopathologia 1993, 123, 81-85.
[39] Da Rosa, D., Gezuele, E., Calegari, L., Goñi, F. Excretion-secretion products and proteases from live
Sporothrix schenckii yeast phase: immunological detection and cleavage of human IgG. Rev Inst Med
Trop Sao Paulo 2009, 51, 1-7.
[40] Sabanero López, M., Flores Villavicencio, L.L., Soto Arredondo, K., Barbosa Sabanero, G.,
Villagómez-Castro, J.C., Cruz Jiménez, G., Sandoval Bernal, G., Torres Guerrero, H. Proteases of
Sporothrix schenckii: Cytopathological effects on a host-cell model.
Rev Iberoam Micol 2018, 35, 32-38.
[41] Hernandez-Chavez, M.J., Perez-Garcia, L.A., Nino-Vega, G.A., Mora-Montes, H.M. Fungal strategies
to evade the host immune recognition. J Fungi (Basel) 2017, 3.
[42] Sánchez-Herrera, R., Flores-Villavicencio, L.L., Pichardo-Molina, J.L., Castruita-Domínguez, J.P.,
Aparicio-Fernández, X., Sabanero López, M., Villagómez-Castro, J.C. Analysis of biofilm formation
by Sporothrix schenckii. Med Mycol 2021, 59, 31-40.
[43] Brilhante, R.S.N., de Aguiar, F.R.M., da Silva, M.L.Q., de Oliveira, J.S., de Camargo, Z.P., Rodrigues,
A.M., Pereira, V.S., Serpa, R., Castelo-Branco, D., Correia, E.E.M., et al. Antifungal susceptibility of
Sporothrix schenckii complex biofilms. Med Mycol 2018, 56, 297-306.
[44] Brilhante, R.S.N., Silva, M., Pereira, V.S., de Oliveira, J.S., Maciel, J.M., Silva, I., Garcia, L.G.S.,
Guedes, G.M.M., Cordeiro, R.A., Pereira-Neto, W.A., et al. Potassium iodide and miltefosine inhibit
biofilms of Sporothrix schenckii species complex in yeast and filamentous forms. Med Mycol 2019,
57, 764-772.
[45] Sanchotene, K.O., Madrid, I.M., Klafke, G.B., Bergamashi, M., Della Terra, P.P., Rodrigues, A.M., de
Camargo, Z.P., Xavier, M.O. Sporothrix brasiliensis outbreaks and the rapid emergence of feline
sporotrichosis. Mycoses 2015, 58, 652-658.
[46] Rodrigues, A.M., de Melo Teixeira, M., de Hoog, G.S., Schubach, T.M., Pereira, S.A., Fernandes, G.F.,
Bezerra, L.M., Felipe, M.S., de Camargo, Z.P. Phylogenetic analysis reveals a high prevalence of
Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLoS Negl Trop Dis 2013, 7, e2281.
[47] Gremião, I.D.F., Martins da Silva da Rocha, E., Montenegro, H., Carneiro, A.J.B., Xavier, M.O., de
Farias, M.R., Monti, F., Mansho, W., de Macedo Assunção Pereira, R.H., Pereira, S.A., et al. Guideline
for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision.
Braz J Microbiol 2021, 52, 107-124.
[48] De Araujo, T., Marques, A.C., Kerdel, F. Sporotrichosis. Int J Dermatol 2001, 40, 737-742.
[49] Duangkaew, L., Yurayart, C., Limsivilai, O., Chen, C., Kasorndorkbua, C. Cutaneous sporotrichosis in
a stray cat from Thailand. Med Mycol case rep 2019, 23, 46-49.
[50] Schubach, T.M., Schubach, A., Okamoto, T., Barros, M.B., Figueiredo, F.B., Cuzzi, T., Pereira, S.A.,
Dos Santos, I.B., Almeida Paes, R., Paes Leme, L.R., et al. Canine sporotrichosis in Rio de Janeiro,
Brazil: clinical presentation, laboratory diagnosis and therapeutic response in 44 cases (1998-2003).
Med Mycol 2006, 44, 87-92.
[51] Viana, P.G., Figueiredo, A.B.F., Gremião, I.D.F., de Miranda, L.H.M., da Silva Antonio, I.M.,
Boechat, J.S., de Sá Machado, A.C., de Oliveira, M.M.E., Pereira, S.A. Successful treatment of canine
sporotrichosis with terbinafine: case reports and literature review.
Mycopathologia 2018, 183, 471- 478.
[52] Miranda, L.H., Conceição-Silva, F., Quintella, L.P., Kuraiem, B.P., Pereira, S.A., Schubach, T.M.
Feline sporotrichosis: histopathological profile of cutaneous lesions and their correlation with clinical
presentation. Comparative immunology, microbiology and infectious diseases 2013, 36, 425-432.
[53] Miranda, L.H.M., Santiago, M.d.A., Schubach, T.M.P., Morgado, F.N., Pereira, S.A., Oliveira,
R.d.V.C.d., Conceição-Silva, F. Severe feline sporotrichosis associated with an increased population
of CD8 low cells and a decrease in CD4 + cells. Med Mycol 2015, 54, 29-39.
[54] de Souza, E.W., Borba, C.M., Pereira, S.A., Gremião, I.D.F., Langohr, I.M., Oliveira, M.M.E., de
Oliveira, R.V.C., da Cunha, C.R., Zancopé-Oliveira, R.M., de Miranda, L.H.M., et al. Clinical features,
fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with
sporotrichosis caused by Sporothrix brasiliensis. Sci Rep 2018, 8, 9074.
[55] Schubach, T.M., Schubach, A., Okamoto, T., Barros, M.B., Figueiredo, F.B., Cuzzi, T., Fialho Monteiro,
P.C., Reis, R.S., Perez, M.A., Wanke, B. Evaluation of an epidemic of sporotrichosis in cats:
347 cases (1998-2001). J Am Vet Med Assoc 2004, 224, 1623-1629.
[56] Gremião, I.D., Schubach, T.M., Pereira, S.A., Rodrigues, A.M., Chaves, A.R., Barros, M.B.
Intralesional amphotericin B in a cat with refractory localised sporotrichosis.
J Fel Med Surg 2009, 11, 720-723,
[57] Cafarchia, C., Sasanelli, M., Lia, R.P., de Caprariis, D., Guillot, J., Otranto, D. Lymphocutaneous and
nasal sporotrichosis in a dog from southern Italy: case report. Mycopathologia 2007, 163, 75-79.
[58] Lopes-Bezerra, L.M., Schubach, A., Costa, R.O. Sporothrix schenckii and sporotrichosis.
An Acad Bras Cienc 2006, 78, 293-308.
[59] Bonifaz, A., Vázquez-González, D. Diagnosis and treatment of lymphocutaneous sporotrichosis:
what are the options? Curr Fungal Infect Rep 2013, 7, 252-259.
[60] Lopes-Bezerra, L.M., Mora-Montes, H.M., Bonifaz, A. Sporothrix and Sporotrichosis. In Current
progress in medical mycology, Mora-Montes, H.M., Lopes-Bezerra, L.M., Eds. Springer, Cham:
Switzerland, 2017; Vol. 1, pp. 309-331.
[61] Vásquez-del-Mercado, E., Arenas, R., Padilla-Desgarenes, C. Sporotrichosis.
Clin Dermatol 2012, 30, 437-443.
[62] Rodrigues, A.M., Della Terra, P.P., Gremião, I.D., Pereira, S.A., Orofino-Costa, R., de Camargo, Z.P.
The threat of emerging and re-emerging pathogenic Sporothrix species. Mycopathologia 2020, 185,
[63] Donabedian, H., O’Donnell, E., Olszewski, C., MacArthur, R.D., Budd, N. Disseminated cutaneous
and meningeal sporotrichosis in an AIDS patient. Diagn Microbiol Infect Dis 1994, 18, 111-115.
[64] Orofino-Costa, R., Macedo, P.M., Rodrigues, A.M., Bernardes-Engemann, A.R. Sporotrichosis: an
update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics.
An Bras Dermatol 2017, 92, 606-620.
[65] Bustamante, B., Campos, P.E. Endemic sporotrichosis. Curr Opin Infect Dis 2001, 14, 145-149.
[66] Bonifaz, A., Saúl, A., Paredes-Solis, V., Fierro, L., Rosales, A., Palacios, C., Araiza, J. Sporotrichosis
in childhood: clinical and therapeutic experience in 25 patients. Ped Dermatol 2007, 24, 369-372.
[67] Chung, G., Kantor, G., Koblenzer, P., Jacoby, R. Fixed cutaneous sporotrichosis.
Arch Dermatol 1990, 126, 399-400.
[68] Mahajan, V.K., Mehta, K.S., Chauhan, P.S., Gupta, M., Sharma, R., Rawat, R. Fixed cutaneous
sporotrichosis treated with topical amphotericin B in an immune suppressed patient. Med Mycol Case
Rep 2015, 7, 23-25.
[69] Mahlberg, M.J., Patel, R., Rosenman, K., Cheung, W., Wang, N., Sanchez, M. Fixed cutaneous
sporotrichosis. Dermat Online J 2009, 15, 5.
[70] Gu, A., Zhang, X., Ma, F., Nie, Z., Sybren de Hoog, G., Zhang, Y. Fixed cutaneous sporotrichosis in a
patient with numerous fungal elements. Med Mycol Case Rep 2020, 29, 32-34.
[71] Liu, F., Liu, Y., Yuan, N., Zhang, X., Cao, M., Dong, J., Zhang, J. Fixed cutaneous sporotrichosis due
to Sporothrix globosa. Clin Cosmet Investig Dermatol 2021, 14, 91-96.
[72] Etchecopaz, A., Toscanini, M.A., Gisbert, A., Mas, J., Scarpa, M., Iovannitti, C.A., Bendezú, K.,
Nusblat, A.D., Iachini, R., Cuestas, M.L. Sporothrix brasiliensis: A review of an emerging south
american fungal pathogen, its related disease, presentation and spread in Argentina. J Fungi (Basel)
2021, 7, 170.
[73] Poester, V.R., Basso, R.P., Stevens, D.A., Munhoz, L.S., de Souza Rabello, V.B., Almeida-Paes, R.,
Zancopé-Oliveira, R.M., Zanchi, M., Benelli, J.L., Xavier, M.O. Treatment of human sporotrichosis
caused by Sporothrix brasiliensis. J Fungi (Basel) 2022, 8, 70.
[74] Bonifaz, A., Tirado-Sánchez, A. Cutaneous disseminated and extracutaneous sporotrichosis:
current status of a complex disease. J Fungi (Basel) 2017, 3, 6.
[75] Hassan, K., Turker, T., Zangeneh, T. Disseminated sporotrichosis in an immunocompetent patient.
Case Reports Plast Surg Hand Surg 2016, 3, 44-47.
[76] Morgan, M.A., Cockerill, F.R., 3rd; Cortese, D.A., Roberts, G.D. Disseminated sporotrichosis with
Sporothrix schenckii fungemia. Diagn Microbiol Infect Dis 1984, 2, 151-155.
[77] Kosinski, R.M., Axelrod, P., Rex, J.H., Burday, M., Sivaprasad, R., Wreiole, A. Sporothrix schenckii
fungemia without disseminated sporotrichosis. J Clin Microbiol 1992, 30, 501-503.
[78] Romero-Cabello, R., Bonifaz, A., Romero-Feregrino, R., Sánchez, C.J., Linares, Y., Zavala, J.T.,
Romero, L.C., Romero-Feregrino, R., Vega, J.T. Disseminated sporotrichosis. BMJ Case Rep 2011,
[79] al-Tawfiq, J.A., Wools, K.K. Disseminated sporotrichosis and Sporothrix schenckii fungemia as the
initial presentation of human immunodeficiency virus infection. Clin Infect Dis 1998, 26, 1403-1406.
[80] Carvalho, M.T., de Castro, A.P., Baby, C., Werner, B., Filus Neto, J., Queiroz-Telles, F. Disseminated
cutaneous sporotrichosis in a patient with AIDS: report of a case. Rev Soc Bra Med Tropl 2002, 35,
[81] Aung, A.K., Teh, B.M., McGrath, C., Thompson, P.J. Pulmonary sporotrichosis: case series and
systematic analysis of literature on clinico-radiological patterns and management outcomes.
Med Mycol 2013, 51, 534-544.
[82] Govender, S., Rasool, M.N., Ngcelwane, M. Osseous sporotrichosis. J Infect 1989, 19, 273-274.
[83] Winn, R.E., Anderson, J., Piper, J., Aronson, N.E., Pluss, J. Systemic sporotrichosis treated with
itraconazole. Clin Infect Dis 1993, 17, 210-217.
[84] Kohler, L.M., Hamdan, J.S., Ferrari, T.C. Successful treatment of a disseminated Sporothrix schenckii
infection and in vitro analysis for antifungal susceptibility testing.
Diagn Microbiol Infect Dis 2007, 58, 117-120.
[85] Mahajan, V.K., Sharma, N.L., Shanker, V., Gupta, P., Mardi, K. Cutaneous sporotrichosis: unusual
clinical presentations. Ind J Dermatol, Venereol Leprol 2010, 76, 276-280.
[86] Freitas, D.F., de Siqueira Hoagland, B., do Valle, A.C., Fraga, B.B., de Barros, M.B., de Oliveira
Schubach, A., de Almeida-Paes, R., Cuzzi, T., Rosalino, C.M., Zancopé-Oliveira, R.M., et al.
Sporotrichosis in HIV-infected patients: report of 21 cases of endemic sporotrichosis in Rio de Janeiro,
Brazil. Med Mycol 2012, 50, 170-178.
[87] Eustace, K.E., Sampaio, F.M., Lyra, M.R., Quintella, L., do Valle, A.C. Cutaneous disseminated
sporotrichosis complicated by osteomyelitis. Acta Dermato-Venereol 2013, 93, 192-193.
[88] Lederer, H.T., Sullivan, E., Crum-Cianflone, N.F. Sporotrichosis as an unusual case of osteomyelitis:
A case report and review of the literature. Med Mycol Case Rep 2016, 11, 31-35.
[89] Kauffman, C.A., Pappas, P.G., McKinsey, D.S., Greenfield, R.A., Perfect, J.R., Cloud, G.A., Thomas,
C.J., Dismukes, W.E., National Institute of, A., Infectious Diseases Mycoses Study, G. Treatment of
lymphocutaneous and visceral sporotrichosis with fluconazole. Clin Infect Dis 1996, 22, 46-50,
[90] Gordhan, A., Ramdial, P.K., Morar, N., Moodley, S.D., Aboobaker, J. Disseminated cutaneous
sporotrichosis: a marker of osteoarticular sporotrichosis masquerading as gout.
Int J Dermatol 2001, 40, 717-719.
[91] Vieira-Dias, D., Sena, C.M., Oréfice, F., Tanure, M.A.G., Hamdan, J.S. Ocular and concomitant
cutaneous sporotrichosis. Mycoses 1997, 40, 197-201.
[92] Kurosawa, A., Pollock, S.C., Collins, M.P., Kraff, C.R., Tso, M.O. Sporothrix schenckii
endophthalmitis in a patient with human immunodeficiency virus infection. Arch Ophthal
(Chicago, Ill: 1960) 1988, 106, 376-380.
[93] Curi, A.L., Félix, S., Azevedo, K.M., Estrela, R., Villar, E.G., Saraça, G. Retinal granuloma caused by
Sporothrix schenckii. American journal of ophthalmology 2003, 136, 205-207.
[94] Ferreira, C.P., Nery, J.A.d., de Almeida, A.C.O., Ferreira, L.C., Corte-Real, S., Conceição-Silva, F.
Parinaud’s oculoglandular syndrome associated with Sporothrix schenckii. IDCases 2014, 1, 38-39.
[95] Yamagata, J.P.M., Rudolph, F.B., Nobre, M.C.L., Nascimento, L.V., Sampaio, F.M.S., Arinelli, A.,
Freitas, D.F. Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis
in epidemic areas. Am J Ophthalmol Case Rep 2017, 8, 35-38, DOI: 10.1016/j.ajoc.2017.09.005.
[96] Freitas, D.F., Lima, I.A., Curi, C.L., Jordão, L., Zancopé-Oliveira, R.M., Valle, A.C., Galhardo, M.C.,
Curi, A.L. Acute dacryocystitis: another clinical manifestation of sporotrichosis.
Mem Inst Oswaldo Cruz 2014, 109, 262-264.
[97] Ramírez Soto, M.C. Sporotrichosis in the ocular adnexa: 21 cases in an endemic area in

Peru and review of the literature. Am J Ophthal 2016, 162, 173-179.e173.
[98] Mitra, A.N., Das, S., Sinha, R., Aggarwal, N., Chakravorty, S. Sporotrichosis of maxillary sinuses in a
middle aged female patient from rural area of eastern India. J Clin Diagn Res 2016, 10, DD01-DD02.
[99] Barros, M.B., Costa, D.L., Schubach, T.M., do Valle, A.C., Lorenzi, N.P., Teixeira, J.L., Schubach
Ade, O. Endemic of zoonotic sporotrichosis: profile of cases in children. The Ped Infect Dis J 2008,
27, 246-250.
[100] Hampton, D.E., Adesina, A., Chodosh, J. Conjunctival sporotrichosis in the absence of antecedent
trauma. Cornea 2002, 21, 831-833.
[101] Schubach, A., Barros, M.B., Wanke, B. Epidemic sporotrichosis. Current opinion in infectious diseases
2008, 21, 129-133.
[102] Gullberg, R.M., Quintanilla, A., Levin, M.L., Williams, J., Phair, J.P. Sporotrichosis: recurrent
cutaneous, articular, and central nervous system infection in a renal transplant recipient. Rev Infect Dis
1987, 9, 369-375.
[103] Moreira, J.A., Freitas, D.F., Lamas, C.C. The impact of sporotrichosis in HIV-infected patients: a
systematic review. Infection 2015, 43, 267-276.
[104] Stroud, J.D. Sporotrichosis presenting as pyoderma gangrenosum. Arch Dermatol 1968, 97, 667-670.
[105] Fonseca-Reyes, S., López Maldonado, F.J., Miranda-Ackerman, R.C., Vélez-Gómez, E., Alvarez Iñiguez,
P., Velarde-Rivera, F.A., Ascensio-Esparza, E.P. Extracutaneous sporotrichosis in a patient
with liver cirrhosis. Revista Iberoam Micol 2007, 24, 41-43.
[106] Duani, H., Palmerston, M.F., Rosa Júnior, J.F., Ribeiro, V.T., Alcântara Neves, P.L. Meningeal and
multiorgan disseminated sporotrichosis: A case report and autopsy study. Med Mycol Case Rep 2019,
26, 47-52.
[107] Yap, F.B. Disseminated cutaneous sporotrichosis in an immunocompetent individual.
Int Soc Infect Dis 2011, 15, e727-e729.
[108] Sendrasoa, F.A., Ranaivo, I.M., Sata, M., Razanakoto, N.H., Andrianarison, M., Ratovonjanahary, V.,
Raharolahy, O., Rakotoarisaona, M., Rasamoelina, T., Andrianarivelo, M.R., et al. Osteoarticular
sporotrichosis in an immunocompetent patient. Med Mycol Case Rep 2021, 32, 50-52.
[109] Garcia, B.M., Bond, A.R., Barry, A.K., Steen, A.J., LeBoit, P.E., Ashbaugh, C., Shinkai, K.
Disseminated-cutaneous sporotrichosis in an immunocompetent adult.
JAAD Case Rep 2021, 11, 102-104.
[110] Castrejón, O.V., Robles, M., Zubieta Arroyo, O.E. Fatal fungaemia due to
Sporothrix schenckii. Mycoses 1995, 38, 373-376.
[111] Solorzano, S., Ramirez, R., Cabada, M.M., Montoya, M., Cazorla, E. Esporotricosis cutánea
diseminada con compromiso articular en una mujer con diabetes tipo 2 [Disseminated cutaneous
sporotrichosis with joint involvement in a woman with type 2 diabetes].
Rev Perú Med Exp Salud Publica 2015, 32, 187-190.
[112] Saeed, L., Weber, R.J., Puryear, S.B., Bahrani, E., Peluso, M.J., Babik, J.M., Haemel, A., Coates, S.J.
Disseminated cutaneous and osteoarticular sporotrichosis mimicking pyoderma gangrenosum. Open
Forum Infect Dis 2019, 6, ofz395.
[113] Barros, N.d.M., Pessoa, A.d.S., Brotas, A.M. Systemic sporotrichosis in an alcoholic patient. Anais
brasileiros de dermatologia 2020, 95, 376-378.
[114] Ewing, G.E., Bosl, G.J., Peterson, P.K. Sporothrix schenckii meningitis in a farmer with Hodgkin’s
disease. Am J Med 1980, 68, 455-457.
[115] Bunce, P.E., Yang, L., Chun, S., Zhang, S.X., Trinkaus, M.A., Matukas, L.M. Disseminated
sporotrichosis in a patient with hairy cell leukemia treated with amphotericin B and posaconazole.
Med Mycol 2012, 50, 197-201.
[116] Kumar, S., Kumar, D., Gourley, W.K., Alperin, J.B. Sporotrichosis as a presenting manifestation of
hairy cell leukemia. Am J Hematol 1994, 46, 134-137.
[117] Gewehr, P., Jung, B., Aquino, V., Manfro, R.C., Spuldaro, F., Rosa, R.G., Goldani, L.Z. Sporotrichosis
in renal transplant patients. Can J Infect Dis Med Microbiol 2013, 24, e47-e49.
[118] Janes, P.C., Mann, R.J. Extracutaneous sporotrichosis. J Hand Surg 1987, 12, 441-445.
[119] Appenzeller, S., Amaral, T.N., Amstalden, E.M., Bertolo, M.B., Neto, J.F., Samara, A.M., Fernandes,
S.R. Sporothrix schenckii infection presented as monoarthritis: report of two cases and review of the
literature. Clinical rheumatology 2006, 25, 926-928.
[120] Costa, R.O., de Mesquita, K.C., Damasco, P.S., Bernardes-Engemann, A.R., Dias, C.M., Silva, I.C.,
Lopes-Bezerra, L.M. Infectious arthritis as the single manifestation of sporotrichosis: serology from
serum and synovial fluid samples as an aid to diagnosis. Rev Iberoam Micol 2008, 25, 54-56, DOI:
[121] Ribeiro, B.N., Ribeiro, R.N., Penna, C.R., Frota, A.C. Bone involvement by Sporothrix schenckii in an
immunocompetent child. Ped Radiol 2015, 45, 1427-1430.
[122] Aung, A.K., Spelman, D.W., Thompson, P.J. Pulmonary sporotrichosis: an evolving clinical paradigm.
Semin Respir Crit Care Med 2015, 36, 756-766.
[123] Comstock, C., Wolson, A.H. Roentgenology of sporotrichosis. Am. J. Roentgenol. Radium Ther Nucl
Med 1975, 125, 651-655, DOI: 10.2214/ajr.125.3.651.
[124] Silva, L.M.C.d., Oliveira, F.d.M., Hochhegger, B., Severo, L.C. Esporotricose pulmonar no Brasil.
relato de caso e revisão. J Trop Pathol 2013, 42.
[125] Mahajan, V.K. Sporotrichosis: an overview and therapeutic options.
Dermatol Res Pract 2014, 2014, 272376.
[126] Rojas, F.D., Fernández, M.S., Lucchelli, J.M., Lombardi, D., Malet, J., Vetrisano, M.E., Cattana, M.E.,
Sosa, M., Giusiano, G. Cavitary pulmonary sporotrichosis: case report and literature review.
Mycopathologia 2017, 182, 1119-1123.
[127] Palomino, J., Saeed, O., Daroca, P., Lasky, J. A 47-year-old man with cough, dyspnea, and an abnormal
chest radiograph. Chest 2009, 135, 872-875.
[128] Callens, S.F., Kitetele, F., Lukun, P., Lelo, P., Van Rie, A., Behets, F., Colebunders, R. Pulmonary
Sporothrix schenckii infection in a HIV positive child. J Trop Pediatr 2006, 52, 144-146.
[129] Silva-Vergara, M.L., Maneira, F.R., De Oliveira, R.M., Santos, C.T., Etchebehere, R.M., Adad, S.J.
Multifocal sporotrichosis with meningeal involvement in a patient with AIDS.
Med Mycol 2005, 43, 187-190.
[130] Vilela, R., Souza, G.F., Fernandes Cota, G., Mendoza, L. Cutaneous and meningeal sporotrichosis in
a HIV patient. Rev Iberoam Micol 2007, 24, 161-163.
[131] Schechtman, R.C., Falcão, E.M.M., Carard, M., García, M.S.C., Mercado, D.S., Hay, R.J.
Sporotrichosis: hyperendemic by zoonotic transmission, with atypical presentations, hypersensitivity
reactions and greater severity. An Bras Dermatol 2022, 97, 1-13,
[132] Freitas, D.F., do Valle, A.C., de Almeida Paes, R., Bastos, F.I., Galhardo, M.C. Zoonotic sporotrichosis
in Rio de Janeiro, Brazil: a protracted epidemic yet to be curbed. Clin Infect Dis 2010, 50, 453.
[133] Oliveira, M.M., Almeida-Paes, R., Muniz, M.M., Gutierrez-Galhardo, M.C., Zancope-Oliveira, R.M.
Phenotypic and molecular identification of Sporothrix isolates from an epidemic area of sporotrichosis
in Brazil. Mycopathologia 2011, 172, 257-267.
[134] Almeida-Paes, R., de Oliveira, L.C., Oliveira, M.M.E., Gutierrez-Galhardo, M.C., Nosanchuk, J.D.,
Zancopé-Oliveira, R.M. Phenotypic characteristics associated with virulence of clinical isolates from
the Sporothrix complex. Biomed Res Int 2015, 212308-212308.
[135] Almeida-Paes, R., de Oliveira, M.M., Freitas, D.F., do Valle, A.C., Zancopé-Oliveira, R.M.,
Gutierrez Galhardo, M.C. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with
atypical clinical presentations. PLoS Negl Trop Dis 2014, 8, e3094.
[136] de Lima Í, M.F., Ferraz, C.E., Gonçalves de Lima-Neto, R., Takano, D.M. Case Report: Sweet
Syndrome in Patients with Sporotrichosis: A 10-Case Series.
The Am J Trop Med Hyg 2020, 103, 2533-2538.
[137] de Lima Barros, M.B., Schubach, T.M., Galhardo, M.C., de Oliviera Schubach, A., Monteiro, P.C.,
Reis, R.S., Zancopé-Oliveira, R.M., dos Santos Lazéra, M., Cuzzi-Maya, T., Blanco, T.C., et al.
Sporotrichosis: an emergent zoonosis in Rio de Janeiro. Mem Inst Oswaldo Cruz 2001, 96, 777-779.
[138] Ozdemir, M., Demirkesen, C., Arzuhal, N., Tüzün, Y. Mucin-poor follicular mycosis fungoides.
Int J Dermatol 2002, 41, 112-114.
[139] Gutierrez-Galhardo, M.C., Barros, M.B., Schubach, A.O., Cuzzi, T., Schubach, T.M., Lazéra, M.S.,
Valle, A.C. Erythema multiforme associated with sporotrichosis. Journal of the European Academy of
Dermatology and Venereology: JEADV 2005, 19, 507-509.
[140] Villarreal-Villarreal, C.D., Ocampo-Candiani, J., Villarreal-Martínez, A. Sweet syndrome: a review
and update. Actas Dermosifiliogr 2016, 107, 369-378.
[141] Winkelmann, R.K., Förström, L. New observations in the histopathology of erythema nodosum.
J Invest Dermatol 1975, 65, 441-446.
[142] Carvalho, G.d.S.M., Veasey, J.V. Immunoreactive cutaneous sporotrichosis.
An Bras Dermatol 2020, 95, 737-739.
[143] Gutierrez Galhardo, M.C., de Oliveira Schubach, A., de Lima Barros, M.B., Moita Blanco, T.C.,
Cuzzi Maya, T., Pacheco Schubach, T.M., dos Santos Lazéra, M., do Valle, A.C. Erythema nodosum
associated with sporotrichosis. Int J Dermatol 2002, 41, 114-116.
[144] Papaiordanou, F., da Silveira, B.R., Abulafia, L.A. Hypersensitivity reaction to Sporothrix schenckii:
erythema nodosum associated with sporotrichosis. Rev Soc Bras Med Trop 2015, 48, 504.
[145] Trayes, K.P., Love, G., Studdiford, J.S. Erythema multiforme: recognition and management. Am Fam
Physician 2019, 100, 82-88.
[146] Barros, M.B., Schubach Ade, O., do Valle, A.C., Gutierrez Galhardo, M.C., Conceição-Silva, F.,
Schubach, T.M., Reis, R.S., Wanke, B., Marzochi, K.B., Conceição, M.J. Cat-transmitted
sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a series of cases.
Clin Infect Dis 2004, 38, 529-535.
[147] Ramos, V., Astacio, G.S., do Valle, A.C.F., de Macedo, P.M., Lyra, M.R., Almeida-Paes, R., Oliveira,
M.M.E., Zancopé-Oliveira, R.M., Brandão, L.G.P., Quintana, M.S.B., Gutierrez-Galhardo, M.C.,
Freitas, D.F.S. Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil.
PLoS Negl Trop Dis 2021, 15, e0009250.
[148] Orofino-Costa, R., Bóia, M.N., Magalhães, G.A., Damasco, P.S., Bernardes-Engemann, A.R.,
Benvenuto, F., Silva, I.C., Lopes-Bezerra, L.M. Arthritis as a hypersensitivity reaction in a case of
sporotrichosis transmitted by a sick cat: clinical and serological follow up of 13 months.
Mycoses 2010, 53, 81-83.
[149] Silva, J.N., Miranda, L.H.M., Menezes, R.C., Gremião, I.D.F., Oliveira, R.V.C., Vieira, S.M.M.,
Conceição-Silva, F., Ferreiro, L., Pereira, S.A. Comparison of the sensitivity of three methods for the
early diagnosis of sporotrichosis in cats. J Comp Pathol 2018, 160, 72-78.
[150] Ramos-e-Silva, M., Vasconcelos, C., Carneiro, S., Cestari, T. Sporotrichosis.
Clin Dermatol 2007, 25, 181-187.
[151] Mauermann, M.L., Klein, C.J., Orenstein, R., Dyck, P.J. Disseminated sporotrichosis presenting with
granulomatous inflammatory multiple mononeuropathies. Muscle nerve 2007, 36, 866-872.
[152] Gerhard, R., de Moscoso, P.C., Gabbi, T.V., Valente, N.Y. Fine-needle aspiration biopsy of
disseminated sporotrichosis: a case report. Diag Cytopath 2008, 36, 174-177.
[153] de Lima Barros, M.B., Schubach, A., Francesconi-do-Valle, A.C., Gutierrez-Galhardo, M.C.,
Schubach, T.M., Conceição-Silva, F., de Matos Salgueiro, M., Mouta-Confort, E., Reis, R.S., de Fátima
Madeira, M., et al. Positive Montenegro skin test among patients with
sporotrichosis in Rio de Janeiro. Acta Trop 2005, 93, 41-47.
[154] Pereira, S.A., Menezes, R.C., Gremião, I.D., Silva, J.N., Honse Cde, O., Figueiredo, F.B., da Silva,
D.T., Kitada, A.A., dos Reis, E.G., Schubach, T.M. Sensitivity of cytopathological examination in the
diagnosis of feline sporotrichosis. J Feline Med Surg 2011, 13, 220-223.
[155] Morris-Jones, R. Sporotrichosis. Clin Exp Dermatol 2002, 27, 427-431.
[156] Han, H.S., Kano, R. Feline sporotrichosis in Asia. Brazilian journal of microbiology: [publication of
the Brazilian Society for Microbiology] 2021, 52, 125-134.
[157] Gezuele, E., Da Rosa, D. Relevancia del cuerpo asteroide esporotricósico en el diagnóstico rápido de
la esporotricosis [Relevance of the sporotrichosis corpus asteroid in the rapid diagnosis of
sporotrichosis]. Rev Iberom Micol 2005, 22, 147-150.
[158] Quintella, L.P., Passos, S.R., do Vale, A.C., Galhardo, M.C., Barros, M.B., Cuzzi, T., Reis Rdos, S.,
de Carvalho, M.H., Zappa, M.B., Schubach Ade, O. Histopathology of cutaneous sporotrichosis in Rio
de Janeiro: a series of 119 consecutive cases. J Cutan Pathol 2011, 38, 25-32.
[159] Zhang, Y.Q., Xu, X.G., Zhang, M., Jiang, P., Zhou, X.Y., Li, Z.Z., Zhang, M.F. Sporotrichosis: clinical
and histopathological manifestations. Am J Dermatopathol 2011, 33, 296-302.
[160] Tshisevhe, V., Skosana, L., Motse, K., Maphosa, T., Mitton, B. Disseminated sporotrichosis in a person
with human immunodeficiency virus disease. Access Microbiol 2021, 3, 000262-000262.
[161] Arenas, R., Sánchez-Cardenas, C.D., Ramirez-Hobak, L., Ruíz Arriaga, L.F., Vega Memije, M.E.
Sporotrichosis: from KOH to molecular biology. J Fungi (Basel) 2018, 4, 62.
[162] Zhou, X., Rodrigues, A.M., Feng, P., de Hoog, G.S. Global ITS diversity in the Sporothrix schenckii
complex. Fungal Divers 2014, 66, 153-165.
[163] Kano, R., Watanabe, K., Murakami, M., Yanai, T., Hasegawa, A. Molecular diagnosis of feline
sporotrichosis. Vet Rec 2005, 156, 484-485.
[164] Rodrigues, A.M., de Hoog, G.S., de Camargo, Z.P. Genotyping species of the Sporothrix schenckii
complex by PCR-RFLP of calmodulin. Diagn Microbiol Infect Dis 2014, 78, 383-387.
[165] Hu, S., Chung, W.-H., Hung, S.-I., Ho, H.-C., Wang, Z.-W., Chen, C.-H., Lu, S.-C., Kuo, T.-T., Hong,
H.-S. Detection of Sporothrix schenckii in clinical samples by a nested PCR assay.
J Clin Microbiol 2003, 41, 1414-1418.
[166] Rodrigues, A.M., Najafzadeh, M.J., de Hoog, G.S., de Camargo, Z.P. Rapid Identification of
emerging human-pathogenic Sporothrix species with rolling circle amplification.
Front Microbiol 2015, 6, 1385-1385, fmicb.2015.01385.
[167] Takata, M., Ishizaki, H. Correlations among culture times, sugar composition and biological activities
of Sporothrix schenckii antigens. Mycopathologia 1983, 84, 31-39.
[168] Bonifaz, A., Toriello, C., Araiza, J., Ramírez-Soto, M.C., Tirado-Sánchez, A. Sporotrichin skin test for
the diagnosis of sporotrichosis. J Fungi (Basel) 2018, 4, 55.
[169] Karlin, J.V., Nielsen, H.S., Jr. Serologic aspects of sporotrichosis.
The Journal of infectious diseases 1970, 121, 316-327.
[170] Lopes-Bezerra, L.M. Sporothrix schenckii cell wall peptidorhamnomannans.
Front Microbiol 2011, 2, 243.
[171] Lima, O.C., Bezerra, L.M.L. Identification of a concanavalin A-binding antigen of the cell surface of
Sporothrix schenckii. J Med Vet Mycol ISHAM 1997, 35, 167-172.
[172] Penha, C.V., Bezerra, L.M. Concanavalin A-binding cell wall antigens of Sporothrix schenckii: a
serological study. Med Mycol 2000, 38, 1-7.
[173] Bernardes-Engemann, A.R., Costa, R.C., Miguens, B.R., Penha, C.V., Neves, E., Pereira, B.A., Dias,
C.M., Mattos, M., Gutierrez, M.C., Schubach, A., et al. Development of an enzyme-linked immuno sorbent
assay for the serodiagnosis of several clinical forms of sporotrichosis. Med Mycol 2005, 43, 487-493.
[174] Bernardes-Engemann, A.R., Loureiro y Penha, C.V., Benvenuto, F., Braga, J.U., Barros, M.L.,
Orofino-Costa, R., Lopes-Bezerra, L.M. A comparative serological study of the SsCBF antigenic
fraction isolated from three Sporothrix schenckii strains. Med Mycol 2009, 47, 874-878.
[175] Fernandes, G.F., dos Santos, P.O., Rodrigues, A.M., Sasaki, A.A., Burger, E., de Camargo, Z.P.
Characterization of virulence profile, protein secretion and immunogenicity of different Sporothrix
schenckii sensu stricto isolates compared with S. globosa and S. brasiliensis species.
Virulence 2013, 4, 241-249.
[176] Martínez-Álvarez, J.A., García-Carnero, L.C., Kubitschek-Barreira, P.H., Lozoya-Pérez, N.E.,
Belmonte-Vázquez, J.L., de Almeida, J.Rf., de J. Gómez-Infante, A., Curty, N., Villagómez-Castro,
J.C., Peña-Cabrera, E., Martínez-Duncker, I., Almeida, S.R., Lopes-Bezerra, L.M., Mora-Montes,
H.M. Analysis of some immunogenic properties of the recombinant Sporothrix schenckii Gp70
expressed in Escherichia coli. Future Microbiol 2019, 14, 397-410.
[177] Kauffman, C.A., Bustamante, B., Chapman, S.W., Pappas, P.G. Clinical practice guidelines for the
management of sporotrichosis: 2007 update by the Infectious Diseases Society of America.
Clin Infect Dis 2007, 45, 1255-1265.
[178] García Carnero, L.C., Lozoya Pérez, N.E., González Hernández, S.E., Martínez Álvarez, J.A.
Immunity and treatment of sporotrichosis. J Fungi (Basel) 2018, 4, 100.
[179] Habte-Gabr, E., Walsh, W. Cutaneous sporotrichosis: the old iodide treatment remains effective.
Clin Microbiol Infect 2000, 6, 53-55.
[180] Sandhu, K., Gupta, S. Potassium iodide remains the most effective therapy for cutaneous
sporotrichosis. J Dermatol Treatment 2003, 14, 200-202.
[181] Coskun, B., Saral, Y., Akpolat, N., Ataseven, A., Ciçek, D. Sporotrichosis successfully treated with
terbinafine and potassium iodide: case report and review of the literature.
Mycopathologia 2004, 158, 53-56.
[182] Fujii, H., Tanioka, M., Yonezawa, M., Arakawa, A., Matsumura, Y., Kore-eda, S., Miyachi, Y.,
Tanaka, S., Mochizuki, T. A case of atypical sporotrichosis with multifocal cutaneous ulcers.
Clin Exp Dermatol 2008, 33, 135-138.
[183] Rex, J.H., Bennett, J.E. Administration of potassium iodide to normal volunteers does not increase
killing of Sporothrix schenckii by their neutrophils or monocytes.
J Med Vet Mycol ISHAM 1990, 28, 185-189.
[184] Sterling, J.B., Heymann, W.R. Potassium iodide in dermatology: a 19th century drug for the 21st
century-uses, pharmacology, adverse effects, and contraindications.
J Am Acad Dermatol 2000, 43, 691-697.
[185] Urabe, H., Nagashima, T. Mechanism of antifungal action of potassium iodide on sporotrichosis.
Dermatol Int 1969, 8, 36-39.
[186] Hiruma, M., Kawada, A., Noguchi, H., Ishibashi, A., Conti Díaz, I.A. Hyperthermic treatment of
sporotrichosis: experimental use of infrared and far infrared rays. Mycoses 1992, 35, 293-299.
[187] Cunningham, K.M., Bulmer, G.S., Rhoades, E.R. Phagocytosis and intracellular fate of
Sporothrix schenckii. J Infect Dis 1979, 140, 815-817.
[188] da Rosa, A.C., Scroferneker, M.L., Vettorato, R., Gervini, R.L., Vettorato, G., Weber, A. Epidemiology
of sporotrichosis: a study of 304 cases in Brazil. J Am Acad Dermatol 2005, 52, 451-459.
[189] Mahajan, V.K., Sharma, N.L., Sharma, R.C., Gupta, M.L., Garg, G., Kanga, A.K. Cutaneous
sporotrichosis in Himachal Pradesh, India. Mycoses 2005, 48, 25-31.
[190] Black, R.A., Hill, D.A. Over-the-counter medications in pregnancy.
Am Fam Phys 2003, 67, 2517- 2524.
[191] Restrepo, A., Robledo, J., Gómez, I., Tabares, A.M., Gutiérrez, R. Itraconazole therapy in lymphangitic
and cutaneous sporotrichosis. Arch Dermatol 1986, 122, 413-417.
[192] Sharkey-Mathis, P.K., Kauffman, C.A., Graybill, J.R., Stevens, D.A., Hostetler, J.S., Cloud, G.,
Dismukes, W.E. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group.
Am J Med 1993, 95, 279-285.
[193] Kauffman, C.A., Hajjeh, R., Chapman, S.W. Practice guidelines for the management of patients with
sporotrichosis. For the Mycoses Study Group. Infectious Diseases Society of America.
Clin Infect Dis 2000, 30, 684-687.
[194] Welsh, R.D. Sporotrichosis. J Am Vet Med Assoc 2003, 223, 1123-1126.
[195] Gremião, I.D., Menezes, R.C., Schubach, T.M., Figueiredo, A.B., Cavalcanti, M.C., Pereira, S.A.
Feline sporotrichosis: epidemiological and clinical aspects. Med Mycol 2015, 53, 15-21.
[196] Castro, L.G., Belda Júnior, W., Cucé, L.C., Sampaio, S.A., Stevens, D.A. Successful treatment of
sporotrichosis with oral fluconazole: a report of three cases. The Brit J Dermatol 1993, 128, 352-356.
[197] Ghodsi, S.Z., Shams, S., Naraghi, Z., Daneshpazhooh, M., Akhyani, M., Arad, S., Ataii, L. Case report.
An unusual case of cutaneous sporotrichosis and its response to weekly fluconazole.
Mycoses 2000, 43, 75-77.
[198] Diaz, M., Negroni, R., Montero-Gei, F., Castro, L.G., Sampaio, S.A., Borelli, D., Restrepo, A., Franco,
L., Bran, J.L., Arathoon, E.G., et al. A Pan-American 5-year study of fluconazole therapy for deep
mycoses in the immunocompetent host. Pan-American Study Group.
Clin Infect Dis 1992, 14 Suppl 1, S68-S76.
[199] Sharma, N.L., Mehta, K.I., Mahajan, V.K., Kanga, A.K., Sharma, V.C., Tegta, G.R. Cutaneous
sporotrichosis of face: polymorphism and reactivation after intralesional triamcinolone. Ind J
Dermatol, Venereol Leprol 2007, 73, 188-190,
[200] Pursley, T.J., Blomquist, I.K., Abraham, J., Andersen, H.F., Bartley, J.A. Fluconazole-induced
congenital anomalies in three infants. Clin Infect Dis 1996, 22, 336-340.
[201] Nakasu, C.C.T., Waller, S.B., Ripoll, M.K., Ferreira, M.R.A., Conceição, F.R., Gomes, A.D.R.,
Osório, L.D.G., de Faria, R.O., Cleff, M.B. Feline sporotrichosis: a case series of itraconazole-resistant
Sporothrix brasiliensis infection. Braz J Microbiol: [publication of the Brazilian Society for
Microbiology] 2021, 52, 163-171.
[202] Sanchotene, K.O., Brandolt, T.M., Klafke, G.B., Poester, V.R., Xavier, M.O. In vitro susceptibility of
Sporothrix brasiliensis: Comparison of yeast and mycelial phases. Med Mycol 2017, 55, 869-876.
[203] Stone, N.R., Bicanic, T., Salim, R., Hope, W. Liposomal amphotericin B (AmBisome(®)):
a review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions.
Drugs 2016, 76, 485-500.
[204] Amirali, M.H., Liebenberg, J., Pillay, S., Nel, J. Sporotrichosis in renal transplant patients:
two case reports and a review of the literature. J Med Case Rep 2020, 14, 79.
[205] Hull, P.R., Vismer, H.F. Treatment of cutaneous sporotrichosis with terbinafine. The Brit J Dermatol
1992, 126 Suppl 39, 51-55.
[206] Francesconi, G., Valle, A.C., Passos, S., Reis, R., Galhardo, M.C. Terbinafine (250 mg/day): an
effective and safe treatment of cutaneous sporotrichosis. J Eur Acad Dermatol Venereol 2009, 23,
[207] Francesconi, G., Francesconi do Valle, A.C., Passos, S.L., de Lima Barros, M.B., de Almeida Paes, R.,
Curi, A.L., Liporage, J., Porto, C.F., Galhardo, M.C. Comparative study of 250 mg/day terbinafine and
100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. Mycopathologia 2011, 171,
[208] Badgwell Doherty, C., Doherty, S.D., Rosen, T. Thermotherapy in dermatologic infections.
J Am Acad Dermatol 2010, 62, 909-927.
[209] Purvis, R.S., Diven, D.G., Drechsel, R.D., Calhoun, J.H., Tyring, S.K. Sporotrichosis presenting as
arthritis and subcutaneous nodules. J Am Acad Dermatol 1993, 28, 879-884.
[210] Ferreira, C.P., Galhardo, M.C., Valle, A.C. Cryosurgery as adjuvant therapy in cutaneous
sporotrichosis. Braz J Infect Dis 2011, 15, 181-183.
[211] Fichman, V., Valle, A., de Macedo, P.M., Freitas, D.F.S., Oliveira, M.M.E., Almeida-Paes, R.,
Gutierrez-Galhardo, M.C. Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant
women. PLoS Negl Trop Dis 2018, 12, e0006434.
[212] Guterres, K.A., de Matos, C.B., Osório Lda, G., Schuch, I.D., Cleff, M.B. The use of (1-3) β-glucan
along with itraconazole against canine refractory sporotrichosis. Mycopathologia 2014, 177, 217-221.
[213] Oliveira, A.H., de Oliveira, G.G., Carnevale Neto, F., Portuondo, D.F., Batista-Duharte, A., Carlos,
I.Z. Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity
against Sporothrix schenckii. J Ethnopharmacol 2017, 195, 266-274.
[214] Gilaberte, Y., Aspiroz, C., Alejandre, M.C., Andres-Ciriano, E., Fortuño, B., Charlez, L., Revillo, M.J.,
Hamblin, M.R., Rezusta, A. Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro
and in vivo study. Photomed Laser Surg 2014, 32, 54-57.


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