Navid Abedpoor^1,2, Farzaneh Tahian¹ and Fatemeh Hajibabaie^2
1Department of Sports Physiology, Faculty of Sports Sciences,
Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
²Department of Physiology, Medicinal Plants Research Center,
Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Part of the book: Advances in Health and Disease. Volume 62

Abstract

Myocardial ischemia (MI) is the most prevalent cardiovascular condition and a primary cause of death worldwide, developing in stages. Several cellular and molecular indicators, such as genes, are implicated in the course of myocardial ischemia. Although text mining and artificial intelligence research revealed acute inflammation, oxidative stress, and necrosis as potential contributors to myocardial damage and coronary artery ischemia, MI has not yet been fully understood. Hence, understanding the pathomechanism and hub genes involved in MI can provide new insight into diagnosis, prognosis, and therapy. Evidence suggests that oxidative stress, inflammation, and apoptosis may play a significant role in MI damage. In contrast, anti-apoptotic and anti-inflammatory mechanisms may protect against reperfusion damage following myocardial ischemia. Detection potential hub genes can help identify the practical and preventive approaches to reduce progressive MI. Moreover, physical activity and exercise may consider protective and preventive strategies to improve cardiovascular diseases. Exercise can improve heart rate, increase reactive oxygen species (ROS) defenses, and activate antioxidant equilibrium as a non-pharmacological intervention. Therefore, this chapter will discuss the hub genes involved in MI conditions and how exercise and physical activity can modulate, improve, and reverse these signaling pathways and hub genes.

References

Abbate, Antonio, Giuseppe GL Biondi-Zoccai, Rossana Bussani, Aldo Dobrina, Debora
Camilot, Florinda Feroce, Raffaele Rossiello, Feliciano Baldi, Furio Silvestri, and
Luigi M Biasucci. 2003. “Increased myocardial apoptosis in patients with unfavorable
left ventricular remodeling and early symptomatic post-infarction heart failure.”
Journal of the American College of Cardiology 41 (5):753-760 .
Abedpoor, Navid, Farzaneh Taghian, and Fatemeh Hajibabaie. 2022. “Physical activity
ameliorates the function of organs via adipose tissue in metabolic diseases.” Acta
histochemica 124 (2):151844 .
Abedpoor, Navid, Farzaneh Taghian, Kamran Ghaedi, Iman Niktab, Zahra Safaeinejad,
Farzaneh Rabiee, Sommayeh Tanhaei, and Mohammad Hossein Nasr-Esfahani. 2018.
“PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of
exercised, branched chain amino acid diet fed mice.” Nutrition & Metabolism 15 (1):1-15 .
Akçapınar, Rumeysa, Bora Garipcan, Vahabodin Goodarzi, and Lokman Uzun. 2021.
“Designing of various biosensor devices for determination of apoptosis: A
comprehensive review.” Biochemical and Biophysical Research Communications
578:42-62 .
Alireza, Andalib, Shokohi Raheleh, Rezaei Abbass, Mokhtari Mojgan, Mohageri
Mohamadreza, Mohageri Gholamreza, and Babazadeh Shadi. 2008. “An
Immunohistochemistry Study of Tissue Bcl‐2 Expression and Its Serum Levels in
Breast Cancer Patients.” Annals of the New York Academy of Sciences 1138 (1):114-120 .
Ansari, Aneesa, Md Shahedur Rahman, Subbroto K Saha, Forhad K Saikot, Akash Deep,
and Ki‐Hyun Kim. 2017. “Function of the SIRT 3 mitochondrial deacetylase in
cellular physiology, cancer, and neurodegenerative disease.” Aging Cell 16 (1):4-16 .
Arias, Consuelo, and Luis A Salazar. 2021. “Autophagy and polyphenols in osteoarthritis:
a focus on epigenetic regulation.” International Journal of Molecular Sciences 23
(1):421 .
Bartekova, Monika, Anureet K Shah, and Naranjan S Dhalla. 2022. “Apoptosis in Ischemic
Heart Disease.” In Biochemistry of Apoptosis and Autophagy, 37 .59 -Springer .
Bedoui, Sammy, Marco J Herold, and Andreas Strasser. 2020. “Emerging connectivity of
programmed cell death pathways and its physiological implications.” Nature Reviews
Molecular Cell Biology 21 (11):678-695 .
Bell, Eric L, and Leonard Guarente. 2011. “The SirT3 divining rod points to oxidative
stress.” Molecular Cell 42 (5):561-568 .
Cao, Min, Ningning Wang, Xu Yan, Ning Yang, Qiang Fu, Xiaoyan Zhang, Yong Zhang,
and Chao Li. 2022. “Structures, evolutionary relationships and expression profiles of
the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes
schlegelii).” Developmental & Comparative Immunology 132:104405 .
Chang, Sukkum Ngullie, Imran Khan, Chang Geon Kim, Seon Min Park, Dong Kyu Choi,
Heejin Lee, Buyng Su Hwang, Sun Chul Kang, and Jae Gyu Park. 2021. “Decursinol
angelate arrest melanoma cell proliferation by initiating cell death and tumor
shrinkage via induction of apoptosis.” International Journal of Molecular Sciences 22
(8):4096 .
Chen, Tao, Shu-Hui Dai, Xia Li, Peng Luo, Jie Zhu, Yu-Hai Wang, Zhou Fei, and Xiao Fan Jiang. 2018. “Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in
response to ischemia.” Redox Biology 14:229-236 .
Chen, Yun, Yuyun Hua, Xinshuai Li, Ishfaq Muhammad Arslan, Wei Zhang, and Guoliang
Meng. 2020. “Distinct types of cell death and the implication in diabetic cardio myopathy.” Frontiers in Pharmacology 11:42 .
Condorelli, Gianluigi, Roberta Roncarati, John Ross Jr, Angela Pisani, Giorgio Stassi,
Matilde Todaro, Stephen Trocha, Alessandra Drusco, Yusu Gu, and Matteo A Russo.
2001. “Heart-targeted overexpression of caspase3 in mice increases infarct size and
depresses cardiac function.” Proceedings of the National Academy of Sciences 98
(17):9977-9982 .
Cutolo, Maurizio, Stefano Soldano, and Vanessa Smith. 2019. “Pathophysiology of
systemic sclerosis: current understanding and new insights.” Expert Review of Clinical
Immunology 15 (7):753-764 .
D’Arcy, Mark S. 2019. “Cell death: a review of the major forms of apoptosis, necrosis and
autophagy.” Cell Biology International 43 (6):582-592 .
Din, Shabana, Matthew Mason, Mirko Völkers, Bevan Johnson, Christopher T Cottage,
Zeping Wang, Anya Y Joyo, Pearl Quijada, Peter Erhardt, and Nancy S Magnuson.
2013. “Pim 1-preserves mitochondrial morphology by inhibiting dynamin-related
protein 1 translocation.” Proceedings of the National Academy of Sciences 110
(15):5969-5974 .
Disatnik, Marie‐Hélène, Julio CB Ferreira, Juliane Cruz Campos, Kátia Sampaio Gomes,
Paulo MM Dourado, Xin Qi, and Daria Mochly‐Rosen. 2013. “Acute inhibition of
excessive mitochondrial fission after myocardial infarction prevents long‐term cardiac
dysfunction.” Journal of the American Heart Association 2 (5):e000461 .
Dondelinger, Yves, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves,
Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A Sehon, and Robert W
Marquis. 2014. “MLKL compromises plasma membrane integrity by binding to
phosphatidylinositol phosphates.” Cell Reports 7 (4 .981 -971:)
Dong, Yan, Hengwen Chen, Jialiang Gao, Yongmei Liu, Jun Li, and Jie Wang. 2019.
“Molecular machinery and interplay of apoptosis and autophagy in coronary heart
disease.” Journal of Molecular and Cellular Cardiology 136:27-41 .
Ejiofor, Stanley Ikenna. 2018. “The role of ambulatory oxygen to improve skeletal muscle
gene expression in Chronic Obstructive Pulmonary Disease in patients with exercise
induced hypoxaemia.” University of Birmingham .
Elmore, Susan. 2007. “Apoptosis: a review of programmed cell death.” Toxicologic
pathology 35 (4):495-516 .
Elsaeed, Eman Mohammed, Ahmed Gamal Hamad, Omnia Sameer Erfan, Mona Abd
Elrahim Elshahat, and Fathy Abd Elghany Ebrahim. 2021. “Role Played by
Hippocampal Apoptosis, Autophagy and Necroptosis in Pathogenesis of Diabetic
Cognitive Dysfunction: A Review of Literature.” Medicine Updates 6 (6):41-63 .
Forte, Maurizio, Leonardo Schirone, Pietro Ameri, Cristina Basso, Daniele Catalucci,
Jessica Modica, Cristina Chimenti, Lia Crotti, Giacomo Frati, and Speranza Rubattu.
2021. “The role of mitochondrial dynamics in cardiovascular diseases.” British
Journal of Pharmacology 178 (10):2060-2076 .
Forte, Maurizio, Silvia Palmerio, Franca Bianchi, Massimo Volpe, and Speranza Rubattu.
2019. “Mitochondrial complex I deficiency and cardiovascular diseases :Current
evidence and future directions.” Journal of Molecular Medicine 97 (5):579-591 .
French, Beverley, Lois H Thomas, Jacqueline Coupe, Naoimh E McMahon, Louise
Connell, Joanna Harrison, Christopher J Sutton, Svetlana Tishkovskaya, and Caroline
L Watkins. 2016. “Repetitive task training for improving functional ability after
stroke.” Cochrane Database of Systematic Reviews .)11(
French, Beverley, Lois H Thomas, Michael J Leathley, Christopher J Sutton, Joanna
McAdam, Anne Forster, Peter Langhorne, Christopher IM Price, Andrew Walker, and
Caroline L Watkins. 2009. “Repetitive task training for improving functional ability
after stroke.” Stroke 40 (4):e98-e99 .
Gil, Hyo-Sun, Jeong-Hun Lee, Ahmed K Farag, Ahmed HE Hassan, Kyung-Sook Chung,
Jung-Hye Choi, Eun-Joo Roh, and Kyung-Tae Lee. 2021. “AKF-D52, a Synthetic
Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and
Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells.” Cancers
13 (22):5849 .
Goswami, Apeksha Bharatgiri, Dimitrije Karadarević, and Natalia Castaño-Rodríguez.
2022. “Immunity-related GTPase IRGM at the intersection of autophagy,
inflammation, and tumorigenesis.” Inflammation Research:1-11 .
Guan, Ruilin, Lina Xie ,Lili Wang, Ying Zhou, Yu Chen, Liangnian Ji, and Hui Chao. 2021.
“Necroptosis-inducing iridium (III) complexes as regulators of cyclin-dependent
kinases.” Inorganic Chemistry Frontiers 8 (7):1788-1794 .
Hajibabaie, Fatemeh, Shirin Kouhpayeh, Mina Mirian ,Ilnaz Rahimmanesh, Maryam
Boshtam, Ladan Sadeghian, Azam Gheibi, Hossein Khanahmad, and Laleh Shariati.
2020. “MicroRNAs as the actors in the atherosclerosis scenario.” Journal of
Physiology and Biochemistry 76 (1):1-12 .
He, Xin, Tailai Du, Tianxin Long ,Xinxue Liao, Yugang Dong, and Zhan-Peng Huang.
2022. “Signaling cascades in the failing heart and emerging therapeutic strategies.”
Signal Transduction and Targeted Therapy 7 (1):1-36 .
Ho, Ming-Yun, and Chao-Yung Wang. 2021. “Role of irisin in myocardial infarction, heart
failure, and cardiac hypertrophy.” Cells 10 (8):2103 .
Homma, Takujiro, Sho Kobayashi, Marcus Conrad, Hiroyuki Konno, Chikako Yokoyama,
and Junichi Fujii. 2021. “Nitric oxide protects against ferroptosis by aborting the lipid
peroxidation chain reaction.” Nitric Oxide 115:34-43 .
Huang, Lishan, Zhou Chen, Ruiyu Chen, Lu Lin, Lingjia Ren, Meilian Zhang, and Libin
Liu. 2022. “Increased fatty acid metabolism attenuates cardiac resistance to β adrenoceptor
activation via mitochondrial reactive oxygen species: A potential
mechanism of hypoglycemia-induced myocardial injury in diabetes.” Redox Biology
52:102320 .
Huang, Shiyuan, Chunhua Xiang, and Yi Song. 2022. “Identification of the shared gene
signatures and pathways between sarcopenia and type 2 diabetes mellitus.” Plos one
17 (3):e0265221 .
Jahani-Asl, Arezu, Eric CC Cheung, Margaret Neuspiel, Jason G MacLaurin, Andre Fortin,
David S Park, Heidi M McBride, and Ruth S Slack. 2007. “Mitofusin 2 protects
cerebellar granule neurons against injury-induced cell death.” Journal of Biological
Chemistry 282 (33):23788-23798 .
Karuppanapandian, Thirupathi, Jun-Cheol Moon, Changsoo Kim, Kumariah Manoharan,
and Wook Kim. 2011. “Reactive oxygen species in plants: their generation, signal
transduction, and scavenging mechanisms.” Australian Journal of Crop Science 5
(6):709-725 .
Khanna, Archita, Papia Acharjee, Arup Acharjee, and Surendra Kumar Trigun. 2019.
“Mitochondrial SIRT3 and neurodegenerative brain disorders.” Journal of Chemical
Neuroanatomy 95:43-53 .
Kitada, Munehiro, and Daisuke Koya. 2021. “Autophagy in metabolic disease and ageing.”
Nature Reviews Endocrinology 17 (11):647-661 .
Kohnert, Klaus-Dieter, Ernst-Joachim Freyse, and Eckhard Salzsieder. 2012. “Glycaemic
Variability and Pancreatic ß-cell Dysfunction.” Current Diabetes Reviews 8 (5):345-354 .
Koren, Elle, and Yaron Fuchs. 2021. “Modes of Regulated Cell Death in CancerModes of
Regulated Cell Death in Cancer.” Cancer Discovery 11 (2):245-265 .
Kroemer, Guido, L Galluzzi, Peter Vandenabeele, J Abrams, Emad S Alnemri, EH
Baehrecke, MV Blagosklonny, WS El-Deiry, P Golstein, and DR Green. 2009.
“Classification of cell death: recommendations of the Nomenclature Committee on
Cell Death 2009.” Cell Death & Differentiation 16 (1):3-11 .
Kulbay, Merve, Adeline Paimboeuf, Derman Ozdemir, and Jacques Bernier. 2021.
“Review of cancer cell resistance mechanisms to apoptosis and actual targeted
therapies.” Journal of Cellular Biochemistry.
Li, Jinze, Qiuke Li, Nan Gao, Zhihua Wang, Feng Li ,Jianping Li, and Anshan Shan. 2021.
“Exopolysaccharides produced by Lactobacillus rhamnosus GG alleviate hydrogen
peroxide-induced intestinal oxidative damage and apoptosis through the Keap1/Nrf2
and Bax/Bcl-2 pathways in vitro.” Food & Function 12 .9641 -9632:)20(
Madamanchi, Nageswara R, and Marschall S Runge. 2007. “Mitochondrial dysfunction in
atherosclerosis.” Circulation Research 100 (4):460-473 .
Mao, Xiao-Yuan, Hong-Hao Zhou, and Wei-Lin Jin. 2019. “Redox-related neuronal death
and crosstalk as drug targets: focus on epilepsy.” Frontiers in Neuroscience 13:512 .
Mao, Zhujun, Shiyu Liu, Tao Yu, Jinglan Su, Kefu Chai, and Siying Weng. 2022. “Yunpi
Heluo decoction reduces ectopic deposition of lipids by regulating the SIRT1-FoxO1
autophagy pathway in diabetic rats.” Pharmaceutical Biology 60 (1):579-588 .
Margonis, Konstantinos, Ioannis G Fatouros, Athanasios Z Jamurtas, Michalis G
Nikolaidis, Ioannis Douroudos, Athanasios Chatzinikolaou, Asimina Mitrakou,
George Mastorakos, Ioannis Papassotiriou, and Kiriakos Taxildaris. 2007. “Oxidative
stress biomarkers responses to physical overtraining: implications for diagnosis.” Free
Radical Biology and Medicine 43 (6):901-910 .
McIlwain, David R, Thorsten Berger, and Tak W Mak. 2013. “Caspase functions in cell
death and disease.” Cold Spring Harbor Perspectives in Biology 5 (4):a008656 .
Meeran, MF Nagoor, Sheikh Azimullah, Ernest Adeghate, and Shreesh Ojha. 2021.
“Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in
isoproterenol-induced myocardial infarction in rats.” Phytomedicine 84:153405 .
Misao, Jun, Yukihiro Hayakawa, Michiya Ohno, Satoshi Kato, Takako Fujiwara, and
Hisayoshi Fujiwara. 1996. “Expression of bcl-2 protein, an inhibitor of apoptosis, and
Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with
myocardial infarction.” Circulation 94 (7):1506-1512 .
Newsholme, Philip, Vinicius Fernandes Cruzat, Kevin Noel Keane, Rodrigo Carlessi, and
Paulo Ivo Homem de Bittencourt Jr. 2016. “Molecular mechanisms of ROS
production and oxidative stress in diabetes.” Biochemical Journal 473 (24):4527-4550 .
Ong, Sang-Bing, Sapna Subrayan, Shiang Y Lim, Derek M Yellon, Sean M Davidson, and
Derek J Hausenloy. 2010. “Inhibiting mitochondrial fission protects the heart against
ischemia/reperfusion injury.” Circulation 121 (18):2012-2022 .
Orrenius, Sten. 2004. “Mitochondrial regulation of apoptotic cell death.” Toxicology
Letters 149 (1-3):19-23 .
Qaisar, Rizwan, Shylesh Bhaskaran, and Holly Van Remmen. 2016. “Muscle fiber type
diversification during exercise and regeneration.” Free Radical Biology and Medicine
98:56-67 .
Rahimi, Golbarg, Salime Heydari, Bahareh Rahimi, Navid Abedpoor, Iman Niktab, Zahra
Safaeinejad, Maryam Peymani, Farzad Seyed Forootan, Zahra Derakhshan, and
Mohammad Hossein Nasr Esfahani. 2021. “A combination of herbal compound
(SPTC) along with exercise or metformin more efficiently alleviated diabetic
complications through down-regulation of stress oxidative pathway upon activating
Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice.” Nutrition &
Metabolism 18 (1):1-14 .
Roedig, Jens, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian
Abhari, Heiko Roedig, Simone Fulda, Petra Beli, and Sjoerd JL van Wijk. 2021 .
“USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3
ubiquitination.” EMBO Reports 22 (2):e50163 .
Ruan, Zhao-hui, Zi-xuan Xu, Xue-yun Zhou, Xian Zhang, and Lei Shang. 2019.
“Implications of necroptosis for cardiovascular diseases.” Current Medical Science 39
(4):513-522 .
Saito, Toshiro, and Junichi Sadoshima. 2015. “Molecular mechanisms of mitochondrial
autophagy/mitophagy in the heart.” Circulation Research 116 (8):1477-1490 .
Sciarretta, Sebastiano, Yasuhiro Maejima, Daniela Zablocki, and Junichi Sadoshima. 2018.
“The role of autophagy in the heart.” Annual Review of Physiology 80:1-26 .
Singh, Abhishek Kumar, and Rakesh Kumar Jat. 2021. “Myocardial Infarction.”
Himalayan Journal of Health Sciences:16-32 .
Sun, Wei, Caixia Liu, Qiuhui Chen, Ning Liu, Youyou Yan, and Bin Liu. 2018. “SIRT3: a
new regulator of cardiovascular diseases.” Oxidative Medicine and Cellular Longevity 2018 .
Talebi, Marjan, Seyyed Ali Mohammadi Vadoud, Alireza Haratian, Mohsen Talebi,
Tahereh Farkhondeh ,Ali Mohammad Pourbagher-Shahri, and Saeed Samarghandian.
2022. “The interplay between oxidative stress and autophagy: focus on the
development of neurological diseases.” Behavioral and Brain Functions 18 (1):1-22 .
Tao, Lichan, Yihua Bei, Haifeng Zhang ,Junjie Xiao, and Xinli Li. 2015. “Exercise for the
heart: signaling pathways.” Oncotarget 6 (25):20773 .
Taylor, Elizabeth, Yujin Kim, Kaleb Zhang, Lenne Chau, Bao Chieu Nguyen, Srujana
Rayalam, and Xinyu Wang. 2022. “Antiaging Mechanism of Natural Compounds:
Effects on Autophagy and Oxidative Stress.” Molecules 27 (14):4396 .
Valaei, Kosar, Shima Taherkhani, Hamid Arazi, and Katsuhiko Suzuki. 2021. “Cardiac
Oxidative Stress and the Therapeutic approaches to the intake of antioxidant
supplements and physical activity.” Nutrients 13 (10):3483 .
Vásquez‐Trincado, César, Ivonne García‐Carvajal, Christian Pennanen, Valentina Parra,
Joseph A Hill, Beverly A Rothermel, and Sergio Lavandero. 2016. “Mitochondrial
dynamics, mitophagy and cardiovascular disease ”.The Journal of Physiology 594
(3):509-525 .
Volpe, Caroline Maria Oliveira, Pedro Henrique Villar-Delfino, Paula Martins Ferreira Dos
Anjos, and José Augusto Nogueira-Machado. 2018. “Cellular death, reactive oxygen
species (ROS) and diabetic complications ”.Cell Death & Disease 9 (2):1-9 .
Walia, Ramanpreet, Reecha Madaan, Komal Chaudhary, Bhawna Mehta, and Rajni Bala.
2021. “Molecular pathways of apoptotic cell death.” In Clinical Perspectives and
Targeted Therapies in Apoptosis, 79-109. Elsevier .
Wang ,Hui, Yihua Bei, Yan Lu, Wei Sun, Qi Liu, Yalong Wang, Yujie Cao, Ping Chen,
Junjie Xiao, and Xiangqing Kong. 2015. “Exercise prevents cardiac injury and
improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC 1α and Akt activation ”.Cellular Physiology and Biochemistry 35 (6):2159-2168 .
Wang, Jian-Xun, Jian-Qin Jiao, Qian Li, Bo Long, Kun Wang, Jin-Ping Liu, Yan-Rui Li,
and Pei-Feng Li. 2011. “miR-499 regulates mitochondrial dynamics by targeting
calcineurin and dynamin-related protein-1.” Nature Medicine 17 (1):71-78 .
Wang, Jing, Jing Liu, Liang Xie, Xiaomin Cai, Xiaohua Ma, and Jianbin Gong. 2020.
“Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia–reperfusion
injury via PI3K/AKT/GSK3β pathway.” Fundamental & Clinical Pharmacology 34
(6):708-720 .
Wang, Kun, Bo Long, Jian-Qin Jiao, Jian-Xun Wang, Jin-Ping Liu, Qian Li, and Pei-Feng
Li. 2012. “miR-484 regulates mitochondrial network through targeting Fis1.” Nature
Communications 3 (1):1-9 .
Xiang, Fei, Yue‐Sheng Huang, Xiao‐Hua Shi, and Qiong Zhang. 2010. “Mitochondrial
chaperone tumour necrosis factor receptor‐associated protein 1 protects
cardiomyocytes from hypoxic injury by regulating mitochondrial permeability
transition pore opening.” The FEBS Journal 277 .1938 -1929 :)8(
Xie, Jieqi, Yuejun Yao, Shuqin Wang, Linge Fan, Jie Ding, Yun Gao, Shifen Li, Liyin
Shen, Yang Zhu, and Changyou Gao. 2022. “Alleviating Oxidative Injury of
Myocardial Infarction by a Fibrous Polyurethane Patch with Condensed ROS‐
Scavenging Backbone Units.” Advanced Healthcare Materials 11 (4):2101855 .
Xu, Qingxue, Bo Zhao, Yingze Ye, Yina Li, Yonggang Zhang, Xiaoxing Xiong, and Lijuan
Gu. 2021. “Relevant mediators involved in and therapies targeting the inflammatory
response induced by activation of the NLRP3 inflammasome in ischemic stroke.”
Journal of Neuroinflammation 18 (1):1-23 .
Yoshitake, Yushi, Daiki Shinozaki, and Kohki Yoshimoto. 2022. “Autophagy triggered by
iron‐mediated ER stress is an important stress response to the early phase of Pi
starvation in plants.” The Plant Journal .
Yuan, Zheng, Grant Dewson, Peter E Czabotar, and Richard W Birkinshaw. 2021.
“VDAC2 and the BCL-2 family of proteins.” Biochemical Society Transactions 49
(6):2787-2795 .
Zarei, Safar, Farzaneh Taghian, Gholamreza Sharifi, and Hassanali Abedi. 2022. “Novel
prevention insights into depletion of oxidative stress status through regular exercise
and grape seed effective substance in heart ischemia rat model.” Food Science &
Nutrition 10 (3):833-845 .
Zepeda, Ramiro, Jovan Kuzmicic, Valentina Parra, Rodrigo Troncoso, Christian Pennanen,
Jaime A Riquelme, Zully Pedrozo, Mario Chiong, Gina Sánchez, and Sergio
Lavandero. 2014. “Drp1 loss-of-function reduces cardiomyocyte oxygen dependence
protecting the heart from ischemia-reperfusion injury.” Journal of Cardiovascular
Pharmacology 63 (6):477-487 .
Zhang, Junxia, Dairu Liu, Mao Zhang, and Yan Zhang. 2019. “Programmed necrosis in
cardiomyocytes: mitochondria, death receptors and beyond.” British Journal of
Pharmacology 176 (22):4319-4339 .
Zhang, Shuping, Wei Xin, Gregory J Anderson, Ruibin Li, Ling Gao, Shuguang Chen,
Jiajun Zhao, and Sijin Liu. 2022. “Double-edge sword roles of iron in driving energy
production versus instigating ferroptosis.” Cell Death & Disease 13 (1):1-13 .
Zhang, Ting, Yan Zhang, Mingyao Cui, LI Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen
Zheng, Haibao Shang, and Jun Zhang. 2016. “CaMKII is a RIP3 substrate mediating
ischemia-and oxidative stress–induced myocardial necroptosis.” Nature Medicine 22
(2):175-182 .
Zhang, Xiao-bo, Yi-cun Hu, Peng Cheng, Hai-yu Zhou, Xiang-yi Chen, Ding Wu, Rui-hao
Zhang, De-chen Yu, Xi-dan Gao, and Jin-tao Shi. 2021. “Targeted therapy for
intervertebral disc degeneration: inhibiting apoptosis is a promising treatment
strategy.” International Journal of Medical Sciences 18 (13):2799 .
Zhang, Yang, Xiaofang Zhang, Benzhi Cai, Ying Li, Yuan Jiang, Xiaoyu Fu, Yue Zhao,
Haiyu Gao, Ying Yang, and Jiming Yang. 2021. “The long noncoding RNA
lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia–
reperfusion injury.” Nature Communications 12 (1):1-15 .
Zhang, Yuan, Yong Zeng, Min Wang, Cui Tian, Xu Ma, Houzao Chen, Quan Fang, Lixin
Jia, Jie Du, and Huihua Li. 2011. “Cardiac-specific overexpression of E3 ligase Nrdp1
increases ischemia and reperfusion-induced cardiac injury.” Basic Research in
Cardiology 106 (3):371-383 .
Zhang, Yuwei, Tianqing Peng, Huaqing Zhu, Xiufen Zheng, Xusheng Zhang, Nan Jiang,
Xiaoshu Cheng, Xiaoyan Lai, Aminah Shunnar, and Manpreet Singh. 2010.
“Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of
Toll-like receptor-4.” Journal of Translational Medicine 8 (1):1-8 .
Zhe-Wei, Shi, Ge Li-Sha, and Li Yue-Chun. 2018. “The role of necroptosis in
cardiovascular disease.” Frontiers in Pharmacology 9:721