Chapter 7. Hub Genes and Their Role in Myocardial Ischemia and How Exercise Can Modulate, Improve, and Reverse These Pathways


Navid Abedpoor1,2, Farzaneh Tahianand Fatemeh Hajibabaie2
Department of Sports Physiology, Faculty of Sports Sciences,
Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2Department of Physiology, Medicinal Plants Research Center,
Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Part of the book: Advances in Health and Disease. Volume 62


Myocardial ischemia (MI) is the most prevalent cardiovascular condition and a primary cause of death worldwide, developing in stages. Several cellular and molecular indicators, such as genes, are implicated in the course of myocardial ischemia. Although text mining and artificial intelligence research revealed acute inflammation, oxidative stress, and necrosis as potential contributors to myocardial damage and coronary artery ischemia, MI has not yet been fully understood. Hence, understanding the pathomechanism and hub genes involved in MI can provide new insight into diagnosis, prognosis, and therapy. Evidence suggests that oxidative stress, inflammation, and apoptosis may play a significant role in MI damage. In contrast, anti-apoptotic and anti-inflammatory mechanisms may protect against reperfusion damage following myocardial ischemia. Detection potential hub genes can help identify the practical and preventive approaches to reduce progressive MI. Moreover, physical activity and exercise may consider protective and preventive strategies to improve cardiovascular diseases. Exercise can improve heart rate, increase reactive oxygen species (ROS) defenses, and activate antioxidant equilibrium as a non-pharmacological intervention. Therefore, this chapter will discuss the hub genes involved in MI conditions and how exercise and physical activity can modulate, improve, and reverse these signaling pathways and hub genes.


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