Chapter 7. Antidiuretic Hormone (Vasopressin)


Aleksandra Faff, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Hormones


Vasopressin is an antidiuretic hormone that actively participates in blood pressure regulation, concentrates urine due to water reabsorption by stimulation of receptors. A disturbed amount of vasopressin may lead to complications related to its deficiency or excess. Too much of this hormone manifests itself in Schwartz-Bartter syndrome. Antidiuretic hormone is also used in the case of vasoplegic shock, because strong vasopressor activity is associated with the activation of V1 receptors. One of the diseases caused by ADH deficiency, i.e., nephrogenic diabetes insipidus, is caused by a defect of vasopressin V2 receptors, which are insensitive to its proper secretion and there are no specific actions in the body that are responsible. Vasopressin analogues or antagonists are often used in the treatment of such disorders.

Keywords: vasopressin, antidiuretic hormone, receptors, kidney, catecholamines


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