Chapter 5. The Chemical Action of Glyceraldehyde-3-Phosphate Dehydrogenase


Magdalena Koman, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes


Glyceraldehyde-3-phosphate dehydrogenase is a protein classified as oxidoreductase, previously known only for its participation in the glycolysis process (it converts G3P into 1,3-bisphosphoglycerate). At the end of the 20th century, however, it was discovered that it is a multifunctional enzyme that is also responsible for iron transport, regulation of gene expression, cytoskeleton formation, protein phosphorylation, cell apoptosis and RNA stabilization.

Keywords: glyceraldehyde-3-phosphate, multifunctional enzyme, biochemistry


Kosova AA, Khodyreva SN, Lavrik OI. Role of Glyceraldehyde-3-Phosphate
Dehydrogenase (GAPDH) in DNA Repair. Biochemistry (Mosc). 2017 Jun;82(6):643-654.
Muronetz VI, Barinova KV, Stroylova YY, Semenyuk PI, Schmalhausen EV.
Glyceraldehyde-3-phosphate dehydrogenase: Aggregation mechanisms and impact on
amyloid neurodegenerative diseases. Int. J. Biol. Macromol. 2017 Jul;100:55-66.
Muronetz VI, Melnikova AK, Barinova KV, Schmalhausen EV. Inhibitors of
Glyceraldehyde 3-Phosphate Dehydrogenase and Unexpected Effects of Its Reduced
Activity. Biochemistry (Mosc). 2019 Nov;84(11):1268-1279.
Sirover MA. Moonlighting glyceraldehyde-3-phosphate dehydrogenase: posttranslational
modification, protein and nucleic acid interactions in normal cells and in human
pathology. Crit. Rev. Biochem. Mol. Biol. 2020 Aug;55(4):354-371.
White MR, Garcin ED. D-Glyceraldehyde-3-Phosphate Dehydrogenase Structure and
Function. Subcell Biochem. 2017;83:413-453.


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