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Natalia Ziaja, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów,Poland
Part of the book: The Biochemical Guide to Hormones
Hepcidin is a protein hormone, determines the proper iron metabolism and the availability of this metal in the body. Thanks to its detection, it became possible to link mechanisms related to inflammation and anemia. It has been shown that too much iron in the brain, associated with hepcidin deficiency, may contribute to the occurrence of degenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease. Lack of iron (Fe3+) leads to pathological deposition of deposits in the organs, which results in the occurrence of neurological disorders. Research shows that an increase in hepcidin in the brain regulates the expression of iron transporting protein in astrocytes, neurons and the blood-brain barrier.
Keywords: hepcidin, hormone, ceruloplasmin, hepcidin-ferroportin axis, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease
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