А. Kusyak¹, А. Petranovska¹, O. Oranska¹, S. Turanska¹, Ya. Shuba², D. Kravchuk², L. Kravchuk², G. Sotkis², V. Nazarenko³, R. Kravchuk³, V. Dubok⁴, O. Bur’yanov⁵, V. Chornyi⁵, Yu. Sobolevsʹkyy⁵ and P. Gorbyk¹
¹Department of Nanomaterials, Chuiko Institute of Surface Chemistry of NAS of Ukraine, Kyiv, Ukraine
²Department of Neuromuscular Physiology, Bogomolets Institute of Physiology of NAS of Ukraine, Kyiv, Ukraine
³Department of Physics of Crystals, Institute of Physics of NAS of Ukraine, Kyiv, Ukraine
⁴Department of Solids Structural Chemistry, Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Kyiv, Ukraine
⁵Department of Traumatology and Orthopedics, Bogomolets National Medical University, Kyiv, Ukraine

Part of the book: What to Know about Lanthanum

Abstract

The aim of the work is the synthesis of nanodispersed phosphors based on lanthanum fluoride and lanthanum phosphate activated by terbium (LaF3:Tb3+ and LaPO4:Tb3+, respectively), promising for use in photodynamic therapy and optopharmacology, study of their structural properties and luminescence as well as the possibility of their use in nanocomposites (NC) with magnetically sensitive nanosized Fe3O4 carriers and 60S bioactive glass. Terbium-activated nanocrystalline lanthanum fluoride and lanthanum phosphate of hexagonal syngony were synthesized. Structural properties, chemical activity of surface, UV and X-ray luminescence spectra of the synthesized crystals have been studied. The possibility is shown to use them in NC with magnetically sensitive nanosized drug carriers and bioactive sol-gel glass. The acid-base nature of the active surface centers of LaF3 and LaF3:Tb3+ NPs was determined. The parts of negatively a ––, positively a + charged and neutral a 0 active centers were calculated in the pH range of 2.4 – 12.7. The detected active centers of the surface can be represented by acidic (La3+) and base (F- ) Lewis centers, as well as base Bronsted centers (OH-groups). The obtained data are useful for optimization of the conditions of adsorption immobilization of molecules of photosensitive substances (photosensitizers) from physiological solution onto the surface of phosphors based on lanthanum fluoride. Ensembles of particles of magnetically sensitive NC Fe3O4/LaF3:Tb3+ of the core-shell type were synthesized. Conditions for the synthesis of NC did not significantly change the magnetic properties of their cores – the original single-domain Fe3O4 nanoparticles. 60S BG composites with nanodispersed crystalline LaF3:Tb3+ and LaPO4:Tb3+ in the dry state, and in distilled water, showed the presence of luminescence upon excitation by UV and X-rays. These data indicate the potential of research into nanodispersed phosphors based on lanthanum fluoride and lanthanum phosphate, their composites with magnetically sensitive nanosized carriers and bioactive glass, for use in optopharmacology and photodynamic therapy of tumor diseases localized in cranial organs and bone tissues. In addition, the results of research can be useful for technical applications, in particular, in the creation of luminescent detectors of high-energy electromagnetic radiation, the development of photo- and optoelectronic devices, etc.

 Keywords: lanthanum fluoride, lanthanum phosphate, luminescent nanostructures, magnetite, nanocomposites, optopharmacology, photodynamic therapy, sol-gel glass

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