Chapter 3. Synthesis and Properties of Nanodispersed Luminescent Structures Based on Lanthanum Fluoride and Phosphate for Optopharmacology and Photodynamic Therapy of Tumor Diseases Localized in Cranial Organs and Bone Tissues

$39.50

А. Kusyak¹, А. Petranovska¹, O. Oranska¹, S. Turanska¹, Ya. Shuba², D. Kravchuk², L. Kravchuk², G. Sotkis², V. Nazarenko³, R. Kravchuk³, V. Dubok⁴, O. Bur’yanov⁵, V. Chornyi⁵, Yu. Sobolevsʹkyy⁵ and P. Gorbyk¹
¹Department of Nanomaterials, Chuiko Institute of Surface Chemistry of NAS of Ukraine, Kyiv, Ukraine
²Department of Neuromuscular Physiology, Bogomolets Institute of Physiology of NAS of Ukraine, Kyiv, Ukraine
³Department of Physics of Crystals, Institute of Physics of NAS of Ukraine, Kyiv, Ukraine
⁴Department of Solids Structural Chemistry, Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Kyiv, Ukraine
⁵Department of Traumatology and Orthopedics, Bogomolets National Medical University, Kyiv, Ukraine

Part of the book: What to Know about Lanthanum

Abstract

The aim of the work is the synthesis of nanodispersed phosphors based on lanthanum fluoride and lanthanum phosphate activated by terbium (LaF3:Tb3+ and LaPO4:Tb3+, respectively), promising for use in photodynamic therapy and optopharmacology, study of their structural properties and luminescence as well as the possibility of their use in nanocomposites (NC) with magnetically sensitive nanosized Fe3O4 carriers and 60S bioactive glass. Terbium-activated nanocrystalline lanthanum fluoride and lanthanum phosphate of hexagonal syngony were synthesized. Structural properties, chemical activity of surface, UV and X-ray luminescence spectra of the synthesized crystals have been studied. The possibility is shown to use them in NC with magnetically sensitive nanosized drug carriers and bioactive sol-gel glass. The acid-base nature of the active surface centers of LaF3 and LaF3:Tb3+ NPs was determined. The parts of negatively a ––, positively a + charged and neutral a 0 active centers were calculated in the pH range of 2.4 – 12.7. The detected active centers of the surface can be represented by acidic (La3+) and base (F- ) Lewis centers, as well as base Bronsted centers (OH-groups). The obtained data are useful for optimization of the conditions of adsorption immobilization of molecules of photosensitive substances (photosensitizers) from physiological solution onto the surface of phosphors based on lanthanum fluoride. Ensembles of particles of magnetically sensitive NC Fe3O4/LaF3:Tb3+ of the core-shell type were synthesized. Conditions for the synthesis of NC did not significantly change the magnetic properties of their cores – the original single-domain Fe3O4 nanoparticles. 60S BG composites with nanodispersed crystalline LaF3:Tb3+ and LaPO4:Tb3+ in the dry state, and in distilled water, showed the presence of luminescence upon excitation by UV and X-rays. These data indicate the potential of research into nanodispersed phosphors based on lanthanum fluoride and lanthanum phosphate, their composites with magnetically sensitive nanosized carriers and bioactive glass, for use in optopharmacology and photodynamic therapy of tumor diseases localized in cranial organs and bone tissues. In addition, the results of research can be useful for technical applications, in particular, in the creation of luminescent detectors of high-energy electromagnetic radiation, the development of photo- and optoelectronic devices, etc.

 Keywords: lanthanum fluoride, lanthanum phosphate, luminescent nanostructures, magnetite, nanocomposites, optopharmacology, photodynamic therapy, sol-gel glass


References


Abramov, M. V., Kusyak, A. P., Kaminskiy, O. M., Turanska, S. P., Petranovska, A. L.,
Kusyak, N. V. and Gorbyk P. P. (2017). Magnetosensitive Nanocomposites Based on
Cisplatin and Doxorubicin for Application in Oncology. In Horizons in World Physics.
293:1-56.
Abramov, M. V., Turanska, S. P. and Gorbyk, P. P. (2018a). Magnetic properties of
nanocomposites of a superparamagnetic core–shell type. Metallofiz. Noveishie
Technol., 40(4):423-500 (in Ukrainian).
Abramov, M. V., Turanska, S. P. and Gorbyk, P. P. (2018b). Magnetic Properties of Fluids
Based on Polyfunctional Nanocomposites of Superparamagnetic Core–Multilevel
Shell Type. Metallofiz. Noveishie Technol., 40(10):1283-1348 (in Ukrainian).
Buryanov, А. А., Chornyi, V. S., Dedukh, N. V., Dubok, V. А., Protsenko, V. V.,
Omelchenko, Т. N., Vakulich, М. V., Lyanskorunskiy, V. N., Shapovalov, V. S. and
Abudeikh, U. (2019). Peculiarities of regenerative reactions in filling bone defects
with bioglass in combination with autologous plasma enriched with platelets. Trauma,
20(6):56-61 (in Russian).
Buryanov, О. А., Chornyi, V. S., Protsenko, V. V., Shapovalov, V. S. and Kusyak, V. А.
(2018). Analysis of replacement of bone defects by calcium phosphate biomaterials in
bone diseases. Litopys Travmat. Ortoped., 1-2(37-38):111-116 (in Ukrainian).
DiMaio, J., Kokuoz, B., James, T. L., Harkey, T., Monofsky, D. and Ballato, J. (2008).
Photoluminescent сharacterization of atomic diffusion in core-shell nanoparticles.
Opt. Exp., 16(16):11769-11775.
Dutra, C. E. A., Pereira, M. M., Serakides, R. and Rezende, C. M. F. (2008). In vivo
evaluation of bioactive glass foams associated with platelet-rich plasma in bone
defects. J. Tissue Eng. Regen. Med., 2(4):221-227.
Foster, K. A., Oster, C. G, Mayer, M. M., Avery, M. L. and Audus, K. L. (1998).
Characterization of the A549 cell line as a type II pulmonary epithelial cell model for
drug metabolism. Exp. Cell Res., 243(2):359-366.
Gorbyk, P. P. (2020). Biomedical nanocomposites with nanorobot functions: state of
research, development, and prospects of practical introduction. Him. Fiz. Tehnol.
Poverhni, 11(1):128-143 (in Ukrainian).
Gorbyk, P. P., Lerman, L. B., Petranovska, A. L., Turanska, S. P. and Pylypchuk, I. V.
(2016). Magnetosensitive Nanocomposites with Hierarchical Nanoarchitecture as
Biomedical Nanorobots: Synthesis, Properties, and Application. In Fabrication and
Self-Assembly of Nanobiomaterials, Applications of Nanobiomaterials. Elsevier. 289-334.
Gorobets’, S. V., Gorobets’, О. Y., Gorbyk, P. P. and Uvarova, І. V. (2018). Functional
Bio- and Nanomaterials of Medical Destination. Kyiv: Kondor (in Ukrainian).
He, H., Xie, M. Y., Ding, Y. and Yu, X. F. (2009). Synthesis of Fe3O4@LaF3:Ce,Tb
nanocomposites with bright fluorescence and strong magnetism. Applied Surface
Science, 255(8):4623-4626.
Hench, L. L. and Fielder, E. (2004). Biological Gel-Glasses. In Sol-Gel Technologies for
Glass Producers and Users, eds. M. A. Aegerter and M. Mennig. Boston: Springer.
Hsiu-Wen, C., Chien-Hao, H., Chien-Hsin, Y. and Tzong-Liu, W. (2020). Synthesis,
optical properties, and sensing applications of LaF3:Yb3+/Er3+/Ho3+/Tm3+
upconversion nanoparticles. Nanomater., 10:2477-2498.
Jing, K., Guo, X., Diao, X., Wu, Q., Jiang, Y., Sun, Y. and Zhu, Y. (2015). Synthesis and
characterization of dipicolinate sensitized LaF3 :Tb3+ nanoparticles and their
interaction with bovine serum albumin. J. Lumin., 157:184-192.
Kasturi, S., Marikumar, R. and Vaidyanathan, S. (2018). Trivalent rare-earth activated
hexagonal lanthanum fluoride (LaF3:RE3+, where RE=Tb, Sm, Dy and Tm)
nanocrystals: Synthesis and optical properties. Luminescence, 33(5):897-906.
Kemnitz, E. and Coman, S. (2016). Nanoscaled Metal Fluorides in Heterogeneous
Catalysis. In New Materials for Catalytic Applications. Elsevier. 133-191.
Kusyak, А. P., Petranovska, A. L., Dubok, V. A., Chornyi, V. S., Bur’yanov, O. A.,
Korniichuk, N. M. and Gorbyk, P. P. (2021). Adsorption immobilization of
chemotherapeutic drug cisplatin on the surface of sol-gel bioglass 60S. Functional
Materials, 28(1):97-105.
Kusyak, А. Р., Petranovska, А. L., Turanska, S. P., Oranska, O. I., Shuba, Y. M., Kravchuk,
D. I., Kravchuk, L. I., Chornyi, V. S., Bur’yanov, O. A., Sobolevs’kyy, Y. L., Dubok,
V. A. and Gorbyk, P. P. (2021). Synthesis and properties of nanostructures based on
lanthanum fluoride for photodynamic therapy of tumors of the cranial cavity and bone
tissue. Him. Fiz. Tehnol. Poverhni, 12(3):216-225.
Liu, Y., Chen, W., Wang, S., Joly, A. G., Westcott, S. and Woo, B. K. (2008). X-ray
luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ water-soluble nanoparticles. J. Appl.
Phys., 103(6):063105. https://doi.org/10.1063/1.2890148.
Mangaiyarkarasi, R., Chinnathambi, S., Karthikeyan, S., Aruna, P. and Ganesan, S. (2016).
Paclitaxel conjugated Fe3O4@LaF3:Ce3+,Tb3+ nanoparticles as bifunctional targeting
carriers for cancer theranostics application. J. Magn. Magn. Mater., 399:207-215.
Medkov, М. А., Steblevskaya, N. I. and Belobeletskaya, М. V. Patent of RF № 2617348
(24.04.2017) “Method for producing of lanthanum phosphate phosphor activated with
cerium and terbium” (in Russian).
Min-Hua, C., Yi-Jhen, J., Sheng-Kai, W., Yo-Shen, C., Nobutaka, H. and Feng-Huei, L.
(2017). Non-invasive photodynamic therapy in brain cancer by use of Tb3+-doped
LaF3 nanoparticles in combination with photosensitizer through X-ray irradiation: a
proof-of-concept study. Nanoscale Res. Let., 12:62-68.
Patro, L. N., Kamala Bharathi, K. and Ravi Chandra Raju, N. (2014). Microstructural and
ionic transport studies of hydrothermally synthesized lanthanum fluoride
nanoparticles. AIP Adv., 4:127139. DOI: 10.1063/1.4904949.
Roco, M. C., Williams, R. S. and Alivisatos, P. (2002). Vision for Nanotechnology R&D in
the Next Decade. Dordrecht: Kluwer Acad. Publ.
Shpak, A. P. and Gorbyk, P. P., eds. (2009). Nanomaterials and Supramolecular
Structures: Physics, Chemistry, and Applications. Netherlands: Springer. 63-78.
Tang, Y., Hu, J., Elmenoufy, A. H. and Yang, X. (2015). Highly efficient FRET system
capable of deep photodynamic therapy established on X-ray excited mesoporous
LaF3:Tb scintillating nanoparticles. ACS Appl. Mater. Int., 7(22):12261-12269.
Tressaud, A. (2010). Functionalized Inorganic Fluorides: Synthesis, Characterization and
Properties of Nanostructured Solids. Chichester: John Wiley & Sons. 101-139.
Zhang, F., Braun, G. B., Pallaoro, A., Zhang, Y., Shi, Y., Cui, D., Moskovits, M., Zhao, D.
and Stucky, G. D. (2011). Mesoporous multifunctional upconversion luminescent and
magnetic “nanorattle” materials for targeted chemotherapy. Nano Let., 12(1):61-67.

Category:

Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!