Chapter 3. Elastin


Weronika Bargiel, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów,
Rzeszów, Poland

Part of the book: The Biochemical Guide to Proteins


Elastin is a unique protein due to its limited synthesis time, long half-life, multi-stage assembly process and a high degree of cross-linking, which provides mechanical flexibility to large arteries. Despite increasing therapeutic opportunities to control diseases such as hypertension, obesity and diabetes, the elastic fiber damage that often accompanies these diseases is now irreparable, meaning that cardiovascular risks from arterial stiffness may persist even when other conditions are present. Aspects of the disease are controlled. Elastin has also been shown to be associated with photoaging and the occurrence of SVAS congenital heart disease – supravalvular aortic stenosis.

Keywords: elastin, supravalvular aortic stenosis (SVAS), large latent complex (LLC), elastogenesis


Cocciolone AJ, Hawes JZ, Staiculescu MC, Johnson EO, Murshed M, Wagenseil JE.
Elastin, arterial mechanics, and cardiovascular disease. Am J Physiol Heart Circ
Physiol, 2018 Aug 1; 315(2):H189-H205.
Duque Lasio ML, Kozel BA. Elastin-driven genetic diseases. Matrix Biol, 2018 Oct; 71-
Vindin H, Mithieux SM, Weiss AS. Elastin architecture. Matrix Biol, 2019 Nov 84: 4-16.
Wang Y, Song EC, Resnick MB. Elastin in the Tumor Microenvironment. Adv Exp Med
Biol, 2020; 1272:1-16.
Weihermann AC, Lorencini M, Brohem CA, de Carvalho CM. Elastin structure and its
involvement in skin photoageing. Int J Cosmet Sci, 2017 Jun; 39(3):241-247.


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!