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Gabriela Pinkowska, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland
Part of the book: The Biochemical Guide to Hormones
Corticoliberin is a peptide that plays a fundamental role in coordinating the neuroendocrine-immune response to stress. It affects the regulation of the feeling of hunger (appetite) in the body and affects the duration of pregnancy, as well as the delivery itself. Its increased amount may stimulate the mechanisms leading to the occurrence of depression and anxiety disorders. In recent years, the knowledge about the complex regulatory mechanisms of corticoliberin activity, including new directions of action of this neuropeptide in the human body, has increased significantly. Understanding its distribution in the central nervous system enables its function as a neurotransmitter and neuromodulator to be determined.
Keywords: corticotropin releasing hormone (CRH), Alzheimer’s disease, corticoliberin, hypothalamic-pituitary-adrenal (HPA)
Battaglia C. R., Cursano S., Calzia E., Catanese A., Boeckers T. M. Corticotropin-releasing
hormone (CRH) alters mitochondrial morphology and function by activating the NF kB-DRP1 axis in hippocampal neurons. Cell Death Dis. 2020 Nov 23;11(11):1004.
Cardoso J. C. R., Bergqvist C. A., Larhammar D. Corticotropin-Releasing Hormone (CRH)
Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome
Doublings. Front Neurosci. 2020 Jul 30;14:672.
Sanchez Jimenez J. G., De Jesus O. Hypothalamic Dysfunction. 2021 Aug 30. In:
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.PMID:
Yi S. Q., An J. X., Liao C. C., Lei S., Jin H., Tuo B. G. The role of corticotropin-releasing
hormone (CRH) family in tumors. Neoplasma. 2021 Sep;68(5):907-916.
Zhang X., Lei B., Yuan Y., Zhang L., Hu L., Jin S., Kang B., Liao X., Sun W., Xu F.,
Zhong Y., Hu J., Qi H. Brain control of humoral immune responses amenable to
behavioural modulation. Nature. 2020 May;581(7807):204-208.