Chapter 26. Corticotropin Releasing Hormone (CRH)


Gabriela Pinkowska, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Hormones


Corticoliberin is a peptide that plays a fundamental role in coordinating the neuroendocrine-immune response to stress. It affects the regulation of the feeling of hunger (appetite) in the body and affects the duration of pregnancy, as well as the delivery itself. Its increased amount may stimulate the mechanisms leading to the occurrence of depression and anxiety disorders. In recent years, the knowledge about the complex regulatory mechanisms of corticoliberin activity, including new directions of action of this neuropeptide in the human body, has increased significantly. Understanding its distribution in the central nervous system enables its function as a neurotransmitter and neuromodulator to be determined.

Keywords: corticotropin releasing hormone (CRH), Alzheimer’s disease, corticoliberin, hypothalamic-pituitary-adrenal (HPA)


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