Patrycja Patronik, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Hormones

Abstract

Thyreoliberin is an important peptide hormone that is responsible for many numerous processes in the body. TRH and its analogues have a significantly shorter half-life, longer duration of effects, and little development of tolerance after prolonged dosing. By acting as an anticonvulsant and suppressing memory impairment, it sheds new light on the treatment of diseases such as Parkinson’s disease and Alzheimer’s disease, which is of great clinical importance. Disorders on the hypothalamic-pituitary-thyroid axis controlled by it can be the source of many diseases such as hyperthyroidism and hypothyroidism. Due to the variety and scale of activity, thyreoliberin and its analogues are still an interesting subject of research.

Keywords: thyrotropin releasing hormone (TRH), Parkinson’s disease, Alzheimer’s disease, hypophysiotropic hormone

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