Chapter 21. Fibroblast Growth Factor (FGF)


Zuzanna Wielgosz, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Proteins


Fibroblast growth factors (FGFs) were first isolated from bovine brain as protein factors with proliferative activity of 3T3 fibroblasts in in vitro cultures. FGFs are synthesized by both resident cells and migrating cells. Eating foods rich in vitamin C and amino acids allows you to increase the number of fibroblasts. Fibroblast growth factors perform a number of important functions in the body including cell proliferation, survival, migration and differentiation. Any irregularities in their functioning lead to a number of developmental defects. Future clinical applications of FGF in the regeneration of tissues, including skin, muscles, tendons, ligaments, bones, teeth and nerves, will be realized when, through appropriate use of stem cells, their biological functions are maximized.

Keywords: fibroblast growth factors (FGF), lacroacousto-dento-digital syndrome (LADD), antioxidant, mammalian cells


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