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Karolina Drygała, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of RzeszĂłw, RzeszĂłw, Poland
Part of the book: The Biochemical Guide to Proteins
GroEL is one of the chaperones that play an essential role in folding non-native proteins and preventing their aggregation. GroEL is a large homotetradecamer composed of two seven-membered rings consisting of two seven-membered 57 kD subunits. It has been found that the first GroES interacting with GroEL does not always dissociate from the symmetric complex prior to dissociation of the second GroES molecule, i.e., dissociation of GroES molecules from this complex may occur in a random order. It was also found that GroEL emerged in three different states: as GroEL itself, as an asymmetric complex and as a symmetric complex. This finding points to the existence of two reaction cycles in the GroEL-GroES interaction: an asymmetric cycle and a symmetric cycle.
Keywords: GroEL, monomolecular test, non-native substrate proteins, polypeptides
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We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!