Chapter 2. Transforming Growth Factors (TGFs)


Piotr Czerniak, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Proteins


Transforming growth factors (TGFs) are polypeptide compounds. TGF’s with relatively low molecular weight, are thermally stable acid inactivated by agents reducing disulfide bonds. Uncontrolled proliferation is a characteristic feature of cancer development. Proteins from the TGF-beta family are inhibitors of cell growth, so their malfunction favors the uncontrolled growth of neoplastic tissue. The results of the current research confirm the increase in mRNA and TGF[1]beta protein expression in cancers of the pancreas, colon, lung, bone and the brain. The huge role of TGFs is played by transforming growth factors in the human body. Continuation of research on TGF-beta and its relationship to the development of neoplastic diseases, may be promising in the context of cancer disease.

Keywords: transforming growth factors (TGFs), glucocorticosteroid, bone
morphogenetic protein (BMP), DNA


Guttmann-Gruber C., Piñón Hofbauer J. Transforming growth factor-β messaging:
#ContextMatters. Br J Dermatol. 2021 Apr;184(4):592-593.
Nickel J., Ten Dijke P., Mueller T. D. TGF-β family co-receptor function and signaling.
Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):12-36.
Qi M., Zhou Q., Zeng W., Wu L., Zhao S., Chen W., Luo C., Shen M., Zhang J., Tang C.
E. Growth factors in the pathogenesis of diabetic foot ulcers. Front Biosci (Landmark
Ed). 2018 Jan 1;23:310-317.
Stocco E., Barbon S., Tortorella C., Macchi V., De Caro R, Porzionato A. Growth Factors
in the Carotid Body-An Update. Int J Mol Sci. 2020 Oct 1;21(19):7267.
Zhang Y. E. Non-Smad Signaling Pathways of the TGF-β Family. Cold Spring Harb
Perspect Biol. 2017 Feb 1;9(2):a022129.


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