Chapter 2. Tropane Alkaloids: Chemical Aspects and Recent Therapeutic Developments


Silky Sethy1, Neha Minocha2 and Rohini Agrawal3
SGT College of Pharmacy, SGT University, Gurugram, Haryana, India
2School of Pharmacy, Chitkara University, Himachal Pradesh, India
3College of Pharmacy, JSS Academy of Technical Education, Noida, India

Part of the book: The Essential Guide to Alkaloids


Tropane alkaloids (TA) are treasured secondary plant metabolites that are frequently determined in high concentrations from Solanaceae and Erythroxylaceae family. The TAs, which can be characterized by their particular bicyclic tropane ring device, may be divided into 3 essential categories: hyoscyamine and scopolamine, cocaine and calystegines. Even though all TAs have the identical primary structure, they range immensely in their biological, chemical and pharmacological properties. Scopolamine, also known as hyoscine, has the most important significant marketplace as a pharmacological agent due to its role in treatment of nausea, vomiting, motion sickness, as well as smooth muscle spasms while cocaine is the second maximum regularly consumed illicit drug globally. This assessment presents a comprehensive review of TAs, highlighting their structural variations, use in pharmaceutical therapy from each ancient and modern perspective, herbal biosynthesis in plants and increasing production opportunities using tissue and microbial biosynthesis of those compounds.

Keywords: tropane alkaloids, solanaceae, cocaine, scopolamine, microbial biosynthesis


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