Chapter 2. Insulin-Like Growth Factor (IGF)


Katarzyna Piekarz, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Hormones


Insulin-like growth factor (IGF) is a peptide hormone that has a significant impact on the growth and development of the body. Its concentration depends on age, gender, insulin levels and nutritional status. In the human body throughout life, the processes of synthesis of building components take place, the replacement of worn-out cells and the reconstruction of tissues caused by damage of various origins takes place, which makes the presence of this ligand in the blood plasma necessary throughout life. The most disturbing and at the same time giving therapeutic hope is the influence of IGF on the pathological proliferation of cells manifested in neoplasms. The high activity of this hormone can lead to the development of the disease. However, knowing the structure of IGF and its receptors well, attempts are made to develop substances that act as inhibitors of IGF-IR receptors in tissues and prevent cells from multiplying in pathological conditions.

Keywords: IGF-I, Insulin-like growth factor (IGF), growth hormone (GH), Insulin receptors


Adamek A, Kasprzak A. Insulin-Like Growth Factor (IGF) System in Liver Diseases. Int J
Mol Sci, 2018; 19(5):1308.
Gusscott S, Tamiro F, Giambra V, Weng AP. Insulin-like growth factor (IGF) signaling in
T-cell acute lymphoblastic leukemia. Adv Biol Regul, 2019; 74:100652.
Kraemer WJ, Ratamess NA, Hymer WC, Nindl BC, Fragala MS. Growth Hormone(s),
Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for
Cellular Development and Growth with Exercise. Front Endocrinol, (Lausanne).
2020; 11:33.
Poreba E, Durzynska J. Nuclear localization and actions of the insulin-like growth factor 1
(IGF-1) system components: Transcriptional regulation and DNA damage response.
Mutat Res Rev Mutat Res, 2020; 784:108307.
Takahashi Y. The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver.
Int J Mol Sci, 2017; 18(7):1447


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!