Chapter 17. Drug Delivery Systems Targeting Fungal Brain Diseases: Achievements, Challenges and Perspectives


Cristina de Castro Spadari, Fernanda Wirth and Kelly Ishida
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

Part of the book: The Book of Fungal Pathogens


Fungal infections have become a public health concern in recent decades. They can cause various pathological conditions, from superficial mycoses to invasive fungal infections (IFIs). Those that affect the central nervous system (CNS) are associated with significant morbidity and mortality. Available antifungal therapies are limited due to toxicity and resistance issues. Additionally, low drug delivery and subsequent bioavailability in the CNS impair some drugs’ efficacy since they must cross the blood-brain barrier (BBB) to achieve ideal concentrations in the brain tissues. This chapter addresses the currently available IFI treatments and discusses the potential use of drug delivery systems that carry antifungal agents across the BBB and target the CNS, consequently increasing drug bioavailability for treating fungal brain diseases.

Keywords: blood-brain barrier, central nervous system, meningitis, nanocarrier


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