Chapter 14. Major Histocompatibility Antigens


Klaudia Fikas, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Proteins


Primary histocompatibility antigens provide immune protection to organisms that express the genes that synthesize these glycoproteins. Understanding the molecules of the main histocompatibility complex has made it possible to demonstrate once again in the world of science the importance of proteins in the body. MHC, which by their diversity play an enormous role in medicine, are also significant in maintaining individual identity. Natural selection is often found to be insufficient to keep MHC gene polymorphisms constant so as to outweigh the natural randomized allele loss process. Research on the spread of diseases (not only infectious) in immunocompromised animal populations may form the basis for further tests on the control of human pathogens in correlation with MHC proteins.

Keywords: major histocompatibility complex (MHC), immune system, human leukocyte antigens (HLA), histocompatibility


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