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Maria Dycha, Dorota Bartusik-Aebisher and David Aebisher
Medical College of the University of Rzeszów, Rzeszów, Poland
Part of the book: The Biochemical Guide to Proteins
Immunoglobulins are glycoproteins secreted by plasma cells in response to the presence of an antigen. There are 5 types of immunoglobulins in the human body: IgM, IgG, IgA, IgE, and IgD. Each type is made up of four polypeptide chains: two light and two heavy, which are linked by a disulfide bridge. IgG is the highest percentage of plasma antibodies and is synthesized in the secondary immune response. IgA is found mainly in secretions, e.g., in saliva, tears and genital secretions, and IgE plays a role in the body’s allergic response and protection against parasites. Immunoglobulins play an essential role in the body’s defense against pathogens, and thanks to their specificity and flexibility, they are an attractive option for the development of therapy against in the different diseases.
Keywords: immunoglobulin, Kawasaki disease, systemic lupus erythematosus (SLE), organ transplants, combined immune disorders (SCID)
Basyal B, KC P. Autoimmune Pancreatitis. 2021 Jul 19. In: StatPearls [Internet]. Treasure
Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32809604.
Bracken SJ, Abraham S, MacLeod AS. Autoimmune Theories of Chronic Spontaneous
Urticaria. Front Immunol. 2019 Mar 29;10:627.
Edlow AG, Li JZ, Collier AY, Atyeo C, James KE, Boatin AA, Gray KJ, Bordt EA, Shook
LL, Yonker LM, Fasano A, Diouf K, Croul N, Devane S, Yockey LJ, Lima R, Shui J,
Matute JD, Lerou PH, Akinwunmi BO, Schmidt A, Feldman J, Hauser BM,
Caradonna TM, De la Flor D, D’Avino P, Regan J, Corry H, Coxen K, Fajnzylber J,
Pepin D, Seaman MS, Barouch DH, Walker BD, Yu XG, Kaimal AJ, Roberts DJ,
Alter G. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load,
Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the
COVID-19 Pandemic. JAMA Netw Open. 2020 Dec 1;3(12):e2030455.
Lu L, Zhang H, Zhan M, Jiang J, Yin H, Dauphars DJ, Li SY, Li Y, He YW. Antibody
response and therapy in COVID-19 patients: what can be learned for vaccine
development? Sci China Life Sci. 2020 Dec;63(12):1833-1849.
Wijdicks EF, Klein CJ. Guillain-Barré Syndrome. Mayo Clin Proc. 2017 Mar;92(3):467-479.