Chapter 12. Deiodinase
Wiktoria Kaliszewska, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Poland
Part of the book: The Biochemical Guide to Enzymes
Iodothyronine deiodinases are selenoproteins acting as enzymes, characterized by the presence of selenocysteine (Sec) in the active site. In the human body, they occur in three isoforms: type I deiodinase (D1), type II deiodinase (D2) and type III deiodinase (D3). These proteins differ in their half-lives – the longest is D3 (12 hours), D1 (8 hours), and D2 is only 45 minutes.
Keywords: selenoproteins, cell metabolism, enzyme
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