Chapter 12. Deiodinase


Wiktoria Kaliszewska, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes 


Iodothyronine deiodinases are selenoproteins acting as enzymes, characterized by the presence of selenocysteine (Sec) in the active site. In the human body, they occur in three isoforms: type I deiodinase (D1), type II deiodinase (D2) and type III deiodinase (D3). These proteins differ in their half-lives – the longest is D3 (12 hours), D1 (8 hours), and D2 is only 45 minutes.

Keywords: selenoproteins, cell metabolism, enzyme


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