Chapter 11. Platelet-Derived Growth Factor (PDGF)


Monika Błądek, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Proteins


Platelet growth factor, a glycoprotein present in several isoforms, is undoubtedly an important factor found in the human body, which is produced by a variety of cells and is widely expressed. Since its discovery the several decades ago, many different studies have been carried out, which allowed to learn about its structure, biosynthesis process and operation. The emergence of different varieties of this factor confirms that it performs many important and different functions. Platelet growth factor is still a factor that is discussed in subsequent scientific research, which is a source of new, valuable and sometimes surprising information. Undoubtedly, the knowledge about this factor will keep increasing, as it is a topic worth further attention.

Keywords: platelet-derived growth factor (PDGF), oligodendrocyte progenitor cells (OPCs), fibrosarcoma, microblastic skin tumors


Cadamuro M., Brivio S., Mertens J., Vismara M., Moncsek A., Milani C., Fingas C.,
Cristina Malerba M., Nardo G., Dall’Olmo L., Milani E., Mariotti V., Stecca T.,
Massani M., Spirli C., Fiorotto R., Indraccolo S., Strazzabosco M., Fabris L. Platelet derived growth factor-D enables liver myofibroblasts to promote tumor
lymphangiogenesis in cholangiocarcinoma. J Hepatol. 2019 Apr;70(4):700-709.
Lee C., Li X. Platelet-derived growth factor-C and -D in the cardiovascular system and
diseases. Mol Aspects Med. 2018 Aug;62:12-21.
Medamana J., Clark R. A., Butler J. Platelet-Derived Growth Factor in Heart Failure.
Handb Exp Pharmacol. 2017;243:355-369.
Roskoski R. Jr. The role of small molecule platelet-derived growth factor receptor
(PDGFR) inhibitors in the treatment of neoplastic disorders. Pharmacol Res. 2018
Shen S., Wang F., Fernandez A., Hu W. Role of platelet-derived growth factor in type II
diabetes mellitus and its complications. Diab Vasc Dis Res. 2020 Jul Aug;17(7):1479164120942119.


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!