Chapter 10. Luteinizing Hormone (LH)


Matylda Mikołajczyk, Dorota Bartusik-Aebisher and David Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Hormones


Luteinizing hormone belongs to the group of hormones with a similar peptide and to the group of gonadotropic hormones. Luteinizing hormone is necessary for the proper functioning of the body of both women and men. Lutropin has clinical application in assisted reproductive techniques and in vitro fertilization. Luteinizing hormone is usually administered by subcutaneous injection in a cyclic and stepwise manner. Like every hormone, it has a certain activation mechanism and therefore its action is possible only after binding to the receptor. It is a steroid hormone, the synthesis of which requires a precursor in the form of lipids. This hormone is extremely important in maintaining a proper menstrual cycle, which is a determinant of a woman’s health and fertility. As the latest research has shown, lutropin supplementation seems to be helpful in getting pregnant through artificial in vitro fertilization. Certainly, the full potential of luteinizing hormone has yet to be discovered.

Keywords: luteinizing hormone (LH), lutropin/choriogonadotropin receptor (LHR), protein kinase A (PKA), protein kinase C (PKC), hypoxia-induced factors (HIF)


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