Chagas Disease: Still a Threat to our World?


Fernanda Ramos Gadelha and Eduardo de Figueiredo Peloso (Editors)
Biochemistry Department, Universidade Estadual de Campinas, Campinas, Brazil

Series: Tropical Diseases – Etiology, Pathogenesis and Treatments
BISAC: HEA039000

Chagas disease is a parasitosis caused by Trypanosoma cruzi that affects approximately 10 million people around the world, mainly in Latin America. There are different types of transmission, and in the last few years, due to the increase in human migration, this pathology has been detected in other continents. Awareness that this disease is now found in places far from endemic areas is relevant since it leads to the development of strategies to prevent potential sources of transmission.

The disease was discovered 100 years ago, and until now, no vaccine has been developed and the drugs currently in use, benznidazole and nifurtimox, have limited efficacy and potentially serious side effects. Chagas disease patients can have gastrointestinal, heart and nervous system related complications, requiring precise and rapid methods of diagnosis. The biology of T. cruzi has been intensively studied allowing for the translation of basic scientific knowledge into a number of select drug candidates for the development of a more specific treatment. Coverage of the latest research techniques and advances in the topics mentioned above, and, most importantly, the new therapeutic targets noted for the development of an improved therapy will be discussed. (Imprint: Nova Biomedical )



Table of Contents


Chapter I – Chagas Disease in Brazil: Historical Aspects
(Simone Petraglia Kropf, History of Science and Health, Casa de Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro-RJ, Brazil)

Chapter II – <i>Trypanosoma cruzi</i>, the Etiologic Agent of Chagas Disease
(Fernanda Ramos Gadelha, Departamento de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas-SP, Brazil)

Chapter III – Epidemiology of Chagas Disease
(João Carlos Pinto Dias and José Rodrigues Coura, Oswaldo Cruz Foundation, Belo Horizonte, Brazil, and others)

Chapter IV – Clinical Aspects of the Disease
(Eros Antônio de Almeida, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas-SP, Brazil)

Chapter V – Clinical and Laboratory Diagnosis
(Marta de Lana, Universidade Federal de Ouro Preto, Ouro-Preto-MG, Brazil)

Chapter VI – Chagas Disease Treatment
(Eduardo de Figueiredo Peloso, Departamento de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas-SP, Brazil)

Chapter VII – New Targets for the Development of an Improved Therapy for Chagas Disease
(Eduardo de Figueiredo Peloso and Fernanda Ramos Gadelha, Universidade Estadual de Campinas, Campinas-SP, Brazil)


Additional information