Chagas Disease: Prevalence, Diagnosis and Treatment Options

Sandra R. Wall (Editor)

Series: Parasites and Parasitic Diseases
BISAC: MED103000

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In Chagas Disease: Prevalence, Diagnosis and Treatment Options, the authors begin reviewing the characterization of American trypanosomiasis, or Chagas Disease, noting that although the disease has become less prevalent in recent decades, it is estimated that 8-10 million people are currently infected. Next, authors present a study wherein the dynamics of Trypanosoma cruzi infection (which causes Chagas disease) were mathematically modeled. This model assumed three clinical stages of the disease; acute, chronic indeterminate, and chronic with determinate pathology. Following this, cysteine proteases, ergosterol metabolic pathways, thiol-dependent mechanisms (trypanothione reductase), glycolytic pathways, trans-sialidase enzymes, the transport and metabolism of polyamines, and examples from literature are described in the context of therapeutic targets. The book goes on to discuss the history of nifurtimox and benznidazole, two drugs used in an effort combat Chagas disease. Additionally, the chapter addresses new therapies in clinical research to develop new treatments for Chagas’ disease. In closing, the authors discuss the idea of targeting the cell cycle of T. cruzi in chemotherapy because the parasite undergoes several morphological changes to adapt to its vertebrate and invertebrate hosts.

Preface

Chapter 1. An Up-To-Date Guide Concerning Chagas Disease (pp. 1-28)
Fernando José Leopoldino Fernandes Candido, Andrey Biff Sarris, Thiago Matnei, Matheo Augusto Morandi Stumpf and Luiz Gustavo Rachid Fernandes

Chapter 2. Mathematical Analysis of the Inter-Human Transmission Dynamics of Chagas Disease in the Absence of Intervention (pp. 29-84)
María del C. Fabrizio, Nicolás J. Schweigmann and Norberto J. Bartoloni

Chapter 3. Therapeutic Targets in Chagas Disease (pp. 85-116)
Cauê Benito Scarim, Diego Eidy Chiba, Rafael Consolin Chelucci, Jean Leandro dos Santos and Chung Man Chin

Chapter 4. Chagas Disease Pharmacotherapy and its Chemical Structure Activity Relationship (pp. 117-136)
Cauê Benito Scarim, Diego Eidy Chiba, Priscila Longhin Bosquesi, Jean Leandro dos Santos and Chung Man Chin

Chapter 5. New Chemotherapeutic Approaches for Targeting the Trypanosoma cruzi Cell Cycle (pp. 137-150)
Luciana Conde, Célio Geraldo Freire-de-Lima, Leonardo Marques da Fonseca, Leonardo Freire-de-Lima and Alexandre Morrot

Index (pp. 151)

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