Cervical Cancer: Screening Methods, Risk Factors and Treatment Options

Laurie Elit, MD (Editor)
Division of Gynecologic Oncology, Hamilton Regional Cancer Centre, Hamilton, ONT, Canada

Series: Cancer Etiology, Diagnosis and Treatments, Obstetrics and Gynecology Advances
BISAC: MED058160

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Globally, cervical cancer is the second leading cause of death for women with cancer. This is a tragedy in part because cervical cancer affects women usually a decade sooner than other cancer when those women are in their reproductive years and in the prime years in the labour force. While screening with the Pap test or other more recently evaluated tests have resulted in low cervical cancer rates in high resource countries, the lack of screening options in low resource countries means that many women present with symptoms reflective of advanced disease and so the chance of survival is low even with aggressive treatment. In this book, we have an international spectrum of authors from both high and low resource settings.

We review the risk factors that lead to cervical cancer. We discuss novel screening techniques including HPV testing. We present the capacity for HPV vaccines to markedly reduce cervical cancer rates. Planning and implementing an organized cervical screening program and the assessment of quality indicators as a means of evaluation is outlined. The exciting role that telemedicine offers for geographically isolated setting is presented. The standard treatment for women once they are diagnosed with cervical cancer is either with radical surgery or radical chemoradiation. In this book we discuss novel operative options in early stage invasive cervical cancer as a means of preserving fertility. As well we discuss the role of neoadjuvant chemotherapy as a means of down staging the disease.

The role of surgically staging women to define more advanced disease is outlined including options for management of metastatic and/or recurrent disease with chemotherapy and targeted therapies. The special situation of women found to be pregnant during the diagnosis of pre-invasive or invasive cervical cancer; the diagnosis and management principles are reviewed. Just as poliomyelitis has almost been eliminated in the lifetime of one generation, we look forward to the eliminated of oncogenic HPV and its deadly ramifications particularly for women exposed to this virus. (Imprint: Nova Biomedical )

Preface

Chapter 1. Cervical Cancer: A Cytological and Molecular Overview
(A.C. Freitas, A.P.A.D. Gurgel, B.S. Chagas and J.C. Silva Neto, Department of Genetics, Federal University of Pernambuco, Brazil, and others)

Chapter 2. Methods for Cervical Cancer Screening: The Differences Between Developing and Developed Countries
(Satoshi Nakagawa, Kiyoshi Yoshino, Yutaka Ueda, Tadashi Kimura
Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, Osaka, Japan)

Chapter 3. Telemedicine and Cervical Screening
(Tsedma Baatar and Laurie Elit, National Center for Maternal and Children’s Health Ulaanbaatar, Mongolia, and others)

Chapter 4. Planning and Implementation of a Cervical Cancer Screening Program
(Laurie Elit, Lars Elffors, Baigalimaa Gendendarjaa, Erdenjargal Ayush, Elena Maximenco and Munkhtaivan Adiya, Ontario Cervical Screening Program, Cancer Care Ontario, Toronto, Ontario, Canada, and others)
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Chapter 5. Risk Factors for Recurrence or Progression in Women Treated for Cervical Intraepithelial Neoplasia
(Begoña Martínez Montoro, Mónica González Macatangga, Ignacio Zapardiel, Margarita Sanchez-Pastor, María Serrano Velasco and Javier de Santiago, Gynecology Department, La Paz University Hospital, Madrid, Spain)

Chapter 6. Quality Indicators for the Practice of Colposcopy in the Screening and Prevention of Cervical Cancer
(Lua R. Eiriksson, Clare J. Reade, Laurie Elit, Department of Obstetrics & Gynecology, Division of Gynecologic Oncology,
University of Toronto, Toronto, Canada, and others)

Chapter 7. Treatment of Cervical Disease: Review of the Current Data
(A.C. Freitas, A.L.S. Jesus and F.C. Mariz, Department of Genetics, Federal University of Pernambuco, Brazil)

Chapter 8. Vaginal Treatment of Early-Stage Cervical Cancer
(Erasmo Bravo, Catalina Alonso, Jaime Cartagena, Sergio Rojas and Carolina Opazo, Gynecologic Oncology Unit, Gustavo Fricke Hospital, Viña del Mar, Chile)

Chapter 9. Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: Current Concepts and Future Challenges
(P. Estevez-Garcia, E. Calvo, I. Duran and I. Diaz-Padilla, Gynecologic Cancer Program. Medical Oncology Department. University Hospital Virgen del Rocio. Seville, Spain and others)

Chapter 10. Surgical Staging of Advanced Cervical Cancer
(Cristina Gonzalez-Benitez, Patricia Salas, Sara Iacoponi, Javier De Santiago, Ignacio Zapardiel, Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain)

Chapter 11. Cervical Carcinoma Metastatic to the Para-Aortic Lymph Node Chain
(Mark Ranck, Gene-Fu Liu and Yasmin Hasan, University of Chicago Department of Radiation and Cellular Oncology, Chicago, IL, USA)

Chapter 12. Targeted Therapeutic Management of Locally Advanced, Recurrent and Metastatic Cervical Cancer
(Craig J. Mulhall and Jermaine I.G. Coward, Mater Adult Hospital, Department of Medical Oncology, Raymond Terrace, Brisbane, QLD, Australia, and others)

Chapter 13. Screening and Treatment of Cervical Cancer in Pregnancy
(Jonathan R. Foote and Jennifer Young Pierce, Medical University of South Carolina, Charleston, SC, USA)

Chapter 14. Historical Overview on Cervical Cancer
(Ciro Comparetto and Franco Borruto, Division of Obstetrics and Gynecology, City Hospital, Prato, Italy, and others)

Index

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