Cerebrospinal Fluid: Clinical Biochemistry, Physiology and Diagnostic Characteristics


Lawrence E. Keen (Editor)

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED057000

The cerebrospinal fluid (CSF) is a dynamic, metabolically active fluid that occupies the subarachnoid space and the ventricular system around the brain, and has many important functions. CSF is a promising body fluid for the search of biomarkers associated with neurological disease, because the CSF has more physical contact with the brain than any other fluids, biochemical changes related to many pathologies may be reflected in the CSF.

Although CSF is obtained by lumbar puncture, invasive and potentially painful for the patient, it is probably the most informative fluid in biomarkers discovery for neurological disease prognosis. This book discusses CSF biomarkers; novel developed biomarkers in neurological diseases; CSF biochemical markers of cerebral metabolism in dogs; and guidance for the selection and interpretation of laboratory tests. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – CSF Biomarkers: Review of the literature and Critical Appraisal in Spinal Cord Injury (pp. 1-14)
Tristan Fried, George M. Ghobrial and James S. Harrop (Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA, and others)

Chapter 2 – Cerebrospinal Fluid: Novel Developed Biomarkers in Neurological Disease (pp. 15-60)
M. Dessi, F. Duranti, M. Pieri, G. Sancesario, R. Zenobi and S. Bernardini (Department of Experimental Medicine and Surgery, “Tor Vergata” University Hospital, Rome, Italy)

Chapter 3 – Cerebrospinal Fluid Biochemical Markers of Cerebral Metabolism in Dogs (pp. 61-74)
Alba Galán and Beatrice E. Carletti (Campus Universitario Rabanales, Department of Animal Medicine and Surgery, Córdoba, Spain)

Chapter 4 – Cerebrospinal Fluid: Guidance for the Selection and Interpretation of Laboratory Tests (pp. 75-106)
Karina Rodríguez-Capote, Vilte E. Barakauskas, Mathew P. Estey and Trefor N. Higgins (DynaLIFEDX Diagnostic Laboratory Services and
The Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada)


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