Cellular Response to Physical Stress and Therapeutic Applications


Tadamichi Shimizu, MD, PhD and Takashi Kondo, PhD (Editors)
University of Toyama, Toyama, Japan

Series: Cell Biology Research Progress
BISAC: SCI017000

Not all that cannot be seized is an illusion! Many effective powers in nature cannot be seized, including magnetism, electricity and sound. However, they contribute to shaping the quality of human life on a daily basis, transcending health and disease as they interact with the human body. Magnetism is important for stability on earth; however, exposure of the body to magnetic fields is not inert. Such exposure has been reported to alter hormone secretion and stimulate bone formation in vivo. Its coupling with electricity provides light and heat to our planet at certain wavelengths. Yet, the infiltration of shorter or longer wavelengths can be disastrous. For instance, ultraviolet radiation can cause inflammatory skin reactions and carcinogenesis at certain levels. In addition, ionizing radiation is claimed to be the driving force for the origin of power resources on earth, while human exposure to radiation is related to the world’s most devastating events.

On the other hand, sound, which is a mechanical wave, has been reported to affect cells at inaudible levels, causing alterations in the gene expression and cell death. All these energies as such are identified to exert physical stresses in a biological milieu especially when thresholds of exposure are exceeded. But still hard times have significance! Researchers have been accumulating knowledge on the biological effects of these physical stressors and their underlying mechanisms on the molecular and genetic levels, that over years they were able to achieve control over these physical stressors for the benefit of human kind. Nowadays, we see most of these energies employed in diagnosis such as magnetic resonance imaging (MRI) and ultrasound as well as in therapeutics.

In our rigorous war against cancer, numerous patients have been cured from tumors by physical means such as ionizing radiation, heating (RF and MW hyperthermia or ablation) or high intensity focused ultrasound (HIFU). Through the chapters of this book, the readers will get introduced to such physical stressors and their biological effects. Recent findings on molecular mechanisms will be thoroughly presented. In addition, perspectives on the modulation of these energies to achieve further therapeutic advantages will be discussed. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1. The Mechanisms of Radiation-Induced Cell Death and its Application for Cancer Therapy @
(Takashi Kondo, Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan)

Chapter 2. Nitric Oxide-Mediated Signal Transduction Induced by Ionizing Radiation
(Hideki Matsumoto, Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui, Japan)

Chapter 3. Biological Effects of Electromagnetic Fields and their Therapeutic Applications
(Tomonori Sakurai, Department of Radiological Technology, School of Health Sciences, Gifu University of Medical Sciences, Seki, Gifu, Japan)

Chapter 4. Electromagnetic Effects in the Nanoscale Range
(Andras Szasz, Department of Biotechnics, St. Istvan University, Godollo, Hungary)

Chapter 5. HSP70 Inducers Protect against UVB-Induced Apoptosis in Keratinocytes
(Yoko Yoshihisa and Tadamichi Shimizu, Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan)

Chapter 6. Ultraviolet-Induced Photokeratitis Treated with Astaxanthin
(Nobuyuki Kitaichi, Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan & Department of Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan)

Chapter 7. Heat-Induced Gene Expression Changes in Cancer Cells
(Yoshiaki Tabuchi, Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Toyama, Japan)
Chapter 8. Heat-Induced DNA Damage
(Akihisa Takahashi, Eiichiro Mori and Takeo Ohnishi, Advanced Scientific Research Leaders Development Unit, Gunma University, Maebashi, Gunma and Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan)
Chapter 9. Ultrasound as an Adjuvant Tool in Drug Delivery
(Mariame Ali Hassan, Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan and Department of Pharmaceutics and Indultrasoundtrial Pharmacy, Faculty of Pharmacy, Cairo University, Egypt)

Chapter 10. Therapeutic Effects of Ultrasound: Physical, Physiological, Cellular and Biomolecular Mechanisms
(Loreto B. Feril, Jr. and Katsuro Tachibana, Department of Anatomy, Fukuoka University School of Medicine, Fukuoka, Japan)


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