Carnosine: Physiological Effects and Research Insights

Dominic Wells (Editor)

Series: Biochemistry Research Trends
BISAC: MED008000

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Carnosine (â-alanyl histidine) is a water-soluble dipeptide. It is mainly distributed in the skeletal muscles and in the brain. It is widely recognized that carnosine has various functions including maintenance of the acid-base balance, antioxidant, protective chelating, and anti-glycation activity. In this book, Chapter One aims to discuss the properties of carnosine and its role in the prevention/inhibition of the oxidation processes occurring in meat and meat products, which are associated with the deterioration of their quality characteristics. Chapter Two reviews the perspective role of carnosine in tumor-related phenomena. Chapter Three reviews the possible mechanisms of neuroprotective functions of carnosine, and discusses the development of drugs for neurodegenerative diseases from food-derived carnosine. Chapter Four studies the neurotropic and protective effects of L-carnosine. Chapter Five focuses on the protective effects of carnosine and its derivative trolox-carnosine against inflammation and oxidative stress in experimental arthritis, carrageenan induced hind paw edema, chondrocytes under H2O2 injury and degradation of hyaluronan. (Imprint: Nova Biomedical)

Preface

Chapter 1. Carnosine: Benefits in Meat and Meat Products Quality and Consumer Health
Cristina Roseiro and Carlos Santos (Instituto Nacional de Investigação Agrária e Veterinária, I.P., Tecnologia e Segurança Alimentar Av. da República, Quinta do Marquês, Oeiras, Portugal)

Chapter 2. Perspective Role of Carnosine in Tumor-Related Phenomena
Filippo Iuliano, Lucia Csaderova, Martina Labudova, Miriam Zatovicova, Monika Barathova, and Jaromir Pastorek (Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia)

Chapter 3. Neuroprotective Effects of Carnosine: Possible Treatment for Neurodegenerative Disease
Masahiro Kawahara, Ken-ichiro Tanaka and Dai Mizuno (Department of Bio Analytical Chemistry, Musashino University, Nishitokyo-shi, Tokyo, Japan, and others)

Chapter 4. Neurotropic and Protective Effects of L-carnosine: Studies in vitro
Anatoly Mokrushin and Larisa Pavlinova (I. P. Pavlov Institute Physiology of the Russian Academy Sciences, Institute of Experimental Medicine, Saint-Petersburg, Russia)

Chapter 5. Protective effects of Carnosine and its Derivative Trolox-Carnosine against Inflammation and Oxidative Stress in Experimental Arthritis, Carrageenan Induced Hind Paw Edema, Chondrocytes Under H2O2 Injury and Degradation of Hyaluronan
S. Ponist, L. Slovak, T. Fedorova, F. Drafi, L. Rackova, K. Valachova, and K. Bauerova (Institute of Experimental Pharmacology and Toxicology of Slovak Academy of Sciences, Bratislava, Slovak Republic, and others)

Index

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