Carbonic Anhydrases: Biochemistry, Mechanism of Action and Therapeutic Applications

Joni Penttinen(Editor)

Series: Biochemistry Research Trends
BISAC: SCI007000

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In this compilation, the authors address the relationship between carbonic anhydrase IX and hypoxia. Hypoxia is a key factor influencing a life-cycle of CA IX, including its expression, correct structure, stability, function, and subsequent biological implications. Hypoxia also regulates CA IX expression by post-transcriptional mechanisms through splicing and mRNA stabilization. A review is provided focusing on the sequence of elementary reactions ensuing a catalytic reaction (catalytic mechanism) of carbonic anhydrase. The closing chapter discusses carbonic anhydrases in chloroplasts, especially their location in the organelles, as well as considers their uses.

Preface

Chapter 1. Carbonic Anhydrase IX and Hypoxia
(Ingeborg Rezuchova and Jaromir Pastorek, Institute of Virology, Biomedical Research Center of Slovak Academy of Sciences, Bratislava, Slovak Republic, and others)

Chapter 2. Structural Insight into the Catalytic Mechanism of Carbonic Anhydrase
(Carrie L. Lomelino, Jacob T. Andring, and Robert McKenna, Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA)

Chapter 3. The Multiplicity of Functions of Carbonic Anhydrases in Higher Plants
(Natalia N. Rudenko, PhD Lyudmila K. Ignatova, PhD, Elena M. Zhurikova, PhD; Mikhail F. Yanyushin, PhD, Boris N. Ivanov, PhD, Institute of Basic Biological Problems of Russian Academy of Sciences, Pushchino, Moscow, Russia)

Index

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