Calcium Binding Lysozymes

Eugene A. Permyakov
Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, Russia

Ludmilla A. Morozova-Roche
Umea University, Umea, Sweden

Lawrence J. Berliner
Denver University, Denver, Colorado, US

Series: Molecular Anatomy and Physiology of Proteins
BISAC: SCI007000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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In this book, the authors describe an important class of calcium binding lysozymes that are evolutionarily related to the lysozyme superfamily and the lactalbumins. The authors take the reader through a journey from the evolution, then the structure and properties of the calcium binding lysozymes. They discuss new unique protein folding pathways with local cooperative, close related folding modes that exhibit multiple folding pathways which are not properties of the lactalbumins or non calcium binding lysozymes. They comprise one of the most diverse group of examples in protein folding. In addition this protein class, especially equine lysozyme, shows peculiar amyloid assembly properties that are not common with other fibril forming proteins. It is one of the first shown to form ring shaped amyloids and other complexes in vitro. Lastly equine lysozyme forms complex with oleic acid, a unique form ELOA, which contributes to the family of the human and bovine lactalbumin analogs HAMLET and BAMLET. (Imprint: Nova Biomedical )


1. Introduction

2. Calcium in biological systems

3. Anatomy of calcium binding lysozymes

4. Physiology of calcium binding lysozymes

5. Dynamics and folding of calcium binding lysozymes

6. Kinetic intermediate states of lysozymes

7. Pathology of calcium binding lysozymes

8. Theraputic properties of calcium-binding lysozymes

9. Concluding remarks

10. References


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