Caenorhabditis elegans – An Overview and Emerging Roles in Studying Disease

Daiana S. Avila (Editor)
Federal University of Pampa, Bagé – RS, Brazil

Series: New Developments in Medical Research
BISAC: SCI007000

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Caenorhabditis elegans – An Overview and Emerging Roles in Studying Disease explores different disease models that have been successfully validated in this nematode, either to unravel disease mechanisms or to perform drug screenings. This nonpathogenic organism has helped to firstly identify genetic mechanisms important in cancer (Ras and Bcl oncogene signaling), aging (insulin signaling), and nervous system development (UNC-6/Netrin signaling). Human conditions such as aging/frailty (Chapter One), metabolic syndrome (Chapter Two), neurodegenerative diseases (Chapters Three and Four) and neurodegeneration induced by chemicals (Chapters Three and Five) are recapitulated in C. elegans. The construction of transgenic animals that mimic the diseases, the advances in understanding molecularly these conditions, potential new treatments and limitations of the models are reviewed in these chapters. Notably, the authors that contributed to this book are from different parts of the world due to the widespread use of this nematode in research.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Studying Frailty in the Nematode Caenorhabditis elegans
(Willian G. Salgueiro, Thiago L. Knittel, Henrique Camara and Marcelo A. Mori, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil)

Chapter 2. Metabolic Syndrome-Like Models in Caenorhabditis elegans
(Caroline Brandão Quines, Daiana Silva Ávila and Priscila Gubert, Universidade Federal do Pampa, Uruguaiana, Rio Grande do Sul, Brazil, and others)

Chapter 3. Caenorhabditis elegans Models to Understand Human Neurodegenerative Diseases
(Marcell Valandro Soares, Danielle Araújo and Daiana Silva Avila, Research Group in Biochemstry and Toxicology in Caenorhabditis elegans (GBToxCE), University Federal do Pampa, Uruguaiana, Rio Grande do Sul)

Chapter 4. Caenorhabditis elegans, a Suitable Model Organism to Investigate Molecular Mechanisms Related to Amyloid Beta Peptide
(Karoline Koch, Sabrina Baier, Christina Saier and Wim Wätjen, Biofunctionality of Secondary Plant Compounds, Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany)

Chapter 5. Caenorhabditis elegans as a Model for Metal-Induced Neurodysfunction
(Samuel W Caito, Tanara V. Peres and Michael Aschner, Department of Basic Pharmaceutical Sciences, Husson University School of Pharmacy, Bangor, ME, US, and others)

Index

Keywords: Caenorhabditis elegans; toxicology; pharmacology; aging; complementary model

This book is directed to people that work with complementary/alternative models or desires to work with C. elegans as an specific topic; is for researchers that want to understand how this invertebrate model can contribute to their research; therefore, this book is directed to researchers at universities and research institutions.

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