Butyrate: Food Sources, Functions and Health Benefits


Cong-Jun Li (Editor)
Bovine Functional Genomics Laboratory, Maryland, USA

Series: Biochemistry Research Trends
BISAC: SCI045000

This is the first book specifically devoted to butyrate and its biological functions in the health of humans and animals. It is the result of the collective efforts of a group of international experts working on different aspects of butyrate. It has been recognized for a long time that the consumption of dietary fibers has positive metabolic health effects.

These effects are directly associated with short-chain fatty acids (SCFAs), particularly butyrate, formed by the microbial degradation of dietary fibers in the digestive tract. Butyrate-induced biological effects provide examples of epigenomic regulation induced by nutrient elements and provide a basis for understanding the full range of the biological roles and molecular mechanisms that butyrate may play in cell growth, proliferation and energy metabolism. This book is a comprehensive collection of highly innovative research ideas, strategies, and crucial points related to butyrate and its biological functions. With a detailed introduction of recent advances in different but intriguing research fields, this book is a great reference for biochemists, molecular biologists, biomedical scientists and clinical researchers. This book is also a great reference for graduate students working in the related fields of biomedical sciences. (Imprint: Nova)

Table of Contents

Table of Contents



Chapter 1 – Enhancing Butyrate Biosynthesis in the Gut for Health Benefits (pp. 1-24)
Robert W. Li and Cong-Jun Li (USDA-ARS, Bovine Functional Genomics Laboratory, Beltsville, MD, USA)

Chapter 2 – Butyrate and Intestinal Function (pp. 25-50)
Jacqueline I. Alvarez-Leite, and Edenil Costa Aguilar (Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil)

Chapter 3 – Large Bowel Short Chain Fatty Acid Production, Immune Status and Immune Cell Function: Implications for Chronic Inflammatory Disease (pp. 51-68)
Kim Y. C. Fung, Leah Cosgrove, Julie Clarke, Trevor Lockett, Tatsuya Morita, Koji Hase and David Topping (CSIRO, Preventative Health National Research Flagship, Australia and others)

Chapter 4 – Butyrate Actions on Carcinogenesis: Focus on Epigenetic Mechanisms (pp. 69-80)
Aline de Conti (National Center for Toxicological Research, Food and Drug Administration (FDA), Jefferson, Arkansas, USA)

Chapter 5 – Potential Beneficial Effects of Butyrate against Food Allergy (pp. 81-90)
Margherita Di Costanzo, Lorella Paparo, Rosita Aitoro, Linda Cosenza, Rita Nocerino, Tommaso Cozzolino, Vincenza Pezzella, Gianfranco Vallone and Roberto Berni Canani (Food Allergy Unit, Department of Translational Medical Science, Pediatric Section, University of Naples “Federico II”, Italy)

Chapter 6 – Short Chain Fatty Acids in Regulation of the Immune System and Tissue Inflammation in the Intestine (pp. 91-108)
Myung H. Kim and Chang H. Kim (Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Weldon School of Biomedical Engineering, Center for Cancer Research, Purdue University, West Lafayette, IN, USA)

Chapter 7 – Biological Effects of Sodium Butyrate in the Regulation of Gene Expression on Astrocytoma Cell Lines and Improvement of Therapies (pp. 109-132)
Monika Garrido-Armas and Francisco Arenas-Huertero (Laboratory of Experimental Pathology, Hospital Infantil de México Federico Gómez, México, D. F. and others)

Chapter 8 – Butyrate, WNT Signaling and Colorectal Cancer (pp. 133-156)
Michael Bordonaro and Darina L. Lazarova (Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA, USA)

Chapter 9 – Butyrate-Mediated Protection against Colonic Inflammation and Colon Carcinogenesis: Role of Butyrate Transporters and Butyrate Receptors (pp. 157-176)
Vadivel Ganapathy, Puttur D. Prasad, Muthusamy Thangaraju, Pamela M. Martin and Nagendra Singh (Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA)

Chapter 10 – Epigenetic Influence of Butyrate Producing Bacteria in Metabolic Syndrome (pp. 177-188)
Marlene Remely, Ines Tesar and Alexander G. Haslberger (Department of Nutritional Sciences, Vienna, Austria)

Chapter 11 – Butyrate Facilitates Epigenetic Reprogramming (pp. 189-198)
Justin E. Brier-Jones, Jason B. Kiroyan and Xiao-Bing Zhang (Loma Linda University School of Medicine)

Chapter 12 – Role and Function of Short Chain Fatty Acids in Rumen Epithelial Metabolism, Development and Importance of the Rumen Epithelium in Understanding Control of Transcriptome (pp. 199-218)
Ransom L. Baldwin, VI and Kyle R. McLeod (Bovine Functional Genomics Laboratory, Agricultural Research Service, US Department of Agriculture, MD, USA and others)

Chapter 13 – Regulation of Cellular Processes by Epigenetic Mechanisms of Butyrate (pp. 219-232)
Kasturi Ranganna, Omana P. Mathew and Shirlette G. Milton (Department of Pharmaceutical Sciences, College of Pharmacy, Texas Southern University, Houston, TX, USA)

Chapter 14 – Butyrate: A Dietary Inhibitor of Histone Deacetylases and an Epigenetic Regulator (pp. 233-258)
Cong-Jun Li, Robert W. Li, Ransom L. Baldwin and Theodore H. Elsasser (Bovine Functional Genomics Laboratory, Agricultural Research Service, US Department of Agriculture, MD, USA and others)


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