Branched-Chain Amino Acids: Metabolism, Benefits and Role in Disease


Series: Chemistry Research and Applications
BISAC: SCI013040

The branched-chain amino acids are unique in chemical structure, metabolism, and that they are essential in the diet of both humans and monogastric food animals. Whether you are a health professional looking to increase your Knowledge of amino acid nutrition on disease, health, and aging, or an agriculture scientists looking to broaden your knowledge of factors influencing amino acid requirements, this text is a must.

This book represents three diverse sections encompassing eleven chapters in total. Section one, being the largest, consist of six chapters addressing the role of branched-chain amino acids in domestic animal and human health. Endocrine and antioxidant systems affected by branched-chain amino acid status are presented, as well as biochemical and molecular mechanisms behind their responses. Moreover, the pros and cons of branched-chain amino acid therapy and balance in sports nutrition, catabolic injury recovery, disease, and successful aging are presented.

The second and third sections of this text are similarly unique, in that they contain five chapters addressing diet needs, digestion, intestinal metabolism, absorption, and subsequent whole-body metabolism at the biochemical and molecular level. Further, two different meta-analyses have been composed using independent branched-chain amino acid data for assessment of food animal needs, in addition to providing insights for controlling metabolic homeostasis via diet formulation. Lastly, and specific for food animal production, the most limiting branched-chain amino acids in swine and poultry diets (e.g., valine and isoleucine) are poised to gain popularity and further price competitiveness in their crystalline L-amino acid forms, and thus, have tremendous environmental implications in terms of planetary nitrogen and water cycling.

Table of Contents

Table of Contents



Section 1. Health Benefits

Chapter 1. Impacts of Branched-Chain Amino Acids on Endocrine Functioning: Lessons from Domestic Animals
(Colin G. Scanes, Department of Poultry Science, University of Arkansas, Fayetteville, AR, USA, and others)

Chapter 2. Natural Antioxidants in Redox Balance Maintenance and Animal Health Protection
(P. F. Surai, I. I. Kochish and M.T. Kidd, Vitagene and Health Research Centre, Bristol, UK, and others)

Chapter 3. Branched-Chain Amino Acids in Recovery from Catabolic Injury
(Elisabet Børsheim, Arkansas Children’s Nutrition Center, Little Rock, AR, USA, and others)

Chapter 4. Branched-Chain Amino Acids in Sports Nutrition: Update and Practical Recommendations
(José Miguel Martínez Sanz, Carlos Ruiz Castellano, Ismael Galancho and Isabel Sospedra López, Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante Spain, and others)

Chapter 5. The Importance of Branched-Chain Amino Acids as Components of Dietary Protein for Successful Aging
(Jamie I. Baum, Aubree L. Hawley, Elisabet Børsheim, and Robert R. Wolfe and Il-Young Kim, Center for Human Nutrition, Department of Food Science, University of Arkansas, Fayetteville, Arkansas, US, and others)

Chapter 6. Branched-Chain Amino Acids and Their Role in Disease
(Navid Abedpoor and Kamran Ghaedi, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran)

Section 2. Food Animal Digestion and Metabolism

Chapter 7. The Involvement of Branched-Chain Amino Acids in Digestive Dynamics
(S. Y. Liu, S. P. Macelline, M. Toghyani, Y. Cao and P. H. Selle, Poultry Research Foundation, Faculty of Science, University of Sydney, NSW, Australia, and others)

Chapter 8. Branched-Chain Amino Acids in Poultry Nutrition: Potential Antagonisms in Practical Feed Formulation
(C. W. Maynard, S. Dridi, S. Y. Liu and M. T. Kidd, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR, USA, and others)

Chapter 9. Digestion, Intestinal Functionality, and Metabolism of Isoleucine and Valine with Emphasis in Poultry
(T. L. Wise, M. T. Kidd and W. A. Dozier, III, Department of Poultry Science, Auburn University, Auburn, AL, USA, and others)

Section 3. Using Algorithms to Assess Dietary Interactions

Chapter 10. Branched-Chain Amino Acid Interactions in Diets for Growing Pigs
(Henrique S. Cemin, Robert D. Goodband and Mike D. Tokach, Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS, USA)

Chapter 11. Quantitative Analysis of Branched-Chain Amino Acid Independent Data Using an All Possible Subset Regression Meta-Analysis
(M. T. Kidd, E. E. Gbur, Jr., J. Caldas, L. A. Mozzoni and C. W. Maynard, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR, USA, and others)


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