Brain Ischemia: Alzheimer’s Disease Mechanisms

Ryszard Pluta, MD, PhD (Editor)
Professor, Head of Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre,
Polish Academy of Sciences, 02-106 Warsaw, Pawińskiego 5 Str., Poland

Series: Neuroscience Research Progress
BISAC: MED056000

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This new book presents a summary of Alzheimer’s disease-related ischemic protein changes and gene expression as risk factors for the late-onset of sporadic Alzheimer’s disease, and their role in Alzheimer’s disease ischemic etiology. Ischemic brain changes were noted in the staining of different parts of an amyloid protein precursor, presenilin 1 and 2, tau protein, alfa-synuclein, and apolipoproteins A1, E and J. Current advances in understanding the ischemic etiology of Alzheimer’s disease has revealed dysregulation of Alzheimer’s disease-associated genes including presenilin 1 and 2, β-secretase, amyloid protein precursor, apoptosis, autophagy, mitophagy, and tau protein. This book presents the relationship between these genes, dysregulated by cerebral ischemia, and the cellular and tissue neuropathology characteristic of Alzheimer’s disease. This book draws attention to the latest research confirming the theory that Alzheimer’s disease-related proteins and genes play an important role in ischemic brain damage, and ischemia is an essential and leading supplier for the onset and progression of sporadic Alzheimer’s disease. The above data comes from the latest research from leading and renowned scientists around the world, who present important information on the understanding of the ischemic etiology of Alzheimer’s disease. In the future, it is likely that the manipulation of ischemia and ischemia-activated Alzheimer’s disease-associated genes and their proteins will give new hope for the development of causal therapies urgently needed to prevent or treat neurodegenerative diseases such as Alzheimer’s disease. An innovative/modern approach to the etiology of Alzheimer’s disease in the chapter XII “Ischemic etiology of Alzheimer’s disease” will give the reader a glimpse of what is on the horizon.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Cognitive Impairment and Dementia Following Ischemic Stroke and Cardiac Arrest in Humans
(Mirosław Czuczwar, MD, PhD, Second Department of Anesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland)

Chapter 2. Neuropathophysiological and Neuropathological Alterations Following Ischemia-Reperfusion Brain Injury Resembling the Changes to the Brain in Alzheimer’s Disease
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 3. The Ischemic Blood-Brain Barrier Behaves like a Blood-Brain Barrier in Alzheimer's Disease
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 4. Alzheimer's Disease-Related Proteins Following Ischemia-Reperfusion Brain Injury
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 5. Expression of Genes Involved in Amyloidogenic Processing of the Amyloid Protein Precursor in the Hippocampus and Temporal Cortex after Brain Ischemia
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 6. Expression of Autophagy, Mitophagy and Apoptosis Genes Associated with Alzheimer's Disease in the Hippocampus and Temporal Cortex after Brain Ischemia
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 7. Ischemic Induction of the Tau Protein Gene Influences the Development of the Alzheimer's Disease Phenotype in the Hippocampus CA1 Neurons
(Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Ryszard Pluta, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 8. Ischemic Brain Injury in Hyperhomocysteinemic Conditions and the Development of Alzheimer's Disease
(Jan Lehotsky, PhD, Maria Kovalska, PhD, Anna Tomascova, Dagmar Kalenska, VMD, Eva Baranovicova, PhD, Peter Kaplan, PhD, Department of Medical Biochemistry and BioMed, Comenius University in Bratislava, Jessenius Medical Faculty in Martin, Martin, Slovakia)

Chapter 9. Dual Role of Autophagy in Ischemia-Reperfusion Brain Injury: Linking Ischemic Autophagy to Alzheimer’s Disease
(Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Ryszard Pluta, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 10. Dual Role of Mitophagy Following Ischemia-Reperfusion Brain Injury: Ischemic Mitophagy Link to Alzheimer’s Disease
(Marzena Ułamek-Kozioł, MD,PhD, Stanisław J. Czuczwar, MD, PhD, Ryszard Pluta, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 11. Post-Ischemic Dementia with Alzheimer’s Disease Phenotype Following Ischemic Stroke in Humans and Experimental Ischemic Brain Injury
(Ryszard Pluta, MD, PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 12. Shared Genomic and Proteomic Contribution to Brain Ischemia and Alzheimer’s Disease: Ischemic Etiology of Alzheimer’s Disease
(Ryszard Pluta, MD., PhD, Marzena Ułamek-Kozioł, MD, PhD, Stanisław J. Czuczwar, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, and others)

Chapter 13. Stroke and Alzheimer's Disease: Common Mechanisms and Therapeutic Approaches
(Lidija Radenovic, PhD, Pavle R. Andjus, PhD, Center for Laser Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia)

Index

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