Brain-Derived Neurotrophic Factor (BDNF): Therapeutic Approaches, Role in Neuronal Development and Effects on Cognitive Health

Christy Bennet (Editor)

Series: Neuroscience Research Progress
BISAC: MED057000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book examines the latest research in brain-derived neurotrophic factor (BDNF) in Huntington’s Disease, in the treatment of diminished glutamatergic signaling in schizophrenia; its role in cognition and treatment response; its importance in the normal course of brain development in which abnormal BDNF expression during critical developmental periods has been increasingly linked to autistic pathology; and finally, a review of proBDNF intracellular and extracellular processing, transport, signaling mechanisms as well as its biological function in health and disease.

(Imprint: Nova Biomedical)

Preface
pp. vii-x

Chapter 1
Involvement of Brain-Derived Neurotrophic Factor (BDNF) in Huntington’s Disease
(Joana Gil-Mohapel, Division of Medical Sciences, UBC Island Medical Program, University of Victoria, Victoria, British Columbia, Canada)
pp. 1-42

Chapter 2
Experimental Rationale for Increasing Brain Derived Neurotrophic Factor (BDNF) in the Treatment of Diminished Glutamatergic Signaling in Schizophrenia
(Kenneth M. Johnson, Yan Xia, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA, and others)
pp. 43-66

Chapter 3
The Role of Brain-Derived Neurotrophic Factor (BDNF) in Cognition and Treatment Response
(Dubravka Svob Strac, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Suzana Uzun, Marina Sagud, Maja Zivkovic, Oliver Kozumplik, Alma Mihaljevic-Peles, Aleksandra Sustar, and Nela Pivac, Rudjer Boskovic Institute, Division of Molecular Medicine, Zagreb, Croatia, and others)
pp. 67-146

Chapter 4
Abnormal Brain BDNF, “Leaky Gut” and Altered Microbiota in Autism
(Elizabeth M. Sajdel-Sulkowska, Michal Bialy, Agnieszka Cudnoch-Jedrzejewska, Dept. Experimental and Clinical Physiology, Warsaw Medical University, Warsaw, Poland, and others)
pp. 147-180

Chapter 5
ProBDNF Biology and Emerging Roles in the CNS: The Unexpected Journey of Proneurotrophins
(Margarita Arango-Lievano, Agustin Anastasia, Freddy Jeanneteau, Dep. Physiology, Institut de genomique fonctionelle; Inserm, Monpellier, France, and others)
pp. 181-198

Index
pp. 199-213

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