Brain and Spinal Cord Plasticity: An Interdisciplinary and Integrative Approach for Behavior, Cognition and Health

Amy Jo Marcano-Reik, PhD
Baldwin Wallace University, Department of Psychology, Neuroscience Program, Berea, Ohio, USA

Series: Neuroscience Research Progress
BISAC: MED057000




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The brain exhibits extraordinarily complex activity and undergoes very rapid change during early development. The ways in which the brain undergoes change during development and interacts with other elements — such as genetics and the environment — can influence behavioral organization. This process of change and the ability to be molded (which is known as plasticity) is important for development, organization, and recovery of function after injury or damage. Through processes involving mechanisms of plasticity, both behavior and cognition can be influenced in many ways important to neurological and psychological function and health. The confluence of brain plasticity, behavior, cognition, and health is complex and requires an interdisciplinary and integrative examination to fully appreciate the biological and psychological implications. The author utilizes this unique approach to review evidence important for behavior and cognition, while addressing important implications for physical and mental health and wellness. (Imprint: Nova Biomedical)



List of Abbreviations

Part I: The Central Nervous System, Plasticity, and Recovery of Function

Chapter 1. Brain Plasticity

Chapter 2. Spinal Cord Plasticity

Chapter 3. Plasticity and Recovery of Function

Part II: The Brain, Cognition, and Health

Chapter 4. Brain and Cognition

Chapter 5. Brain Health and Medicine



Amy Jo Marcano-Reik is known for her engaging, personable, simplified and
enthusiastic presentation of complex aspects of psychology and biology, and this
book is no exception. This book reads like you’re having a cup of coffee with a
wise, warm friend who is explaining the brilliant connections she sees among
some of the most important research on the brain and spinal cord, while
describing the research in just enough detail to really grasp the conclusions,
which revolve around the hopeful message of plasticity -- the ability of the brain
and spinal cord to grow and change over time in response to experience. This
book is jam-packed with information ranging from the accomplishments of Nobel
Prize Winners, details about ground breaking neuroscientific methods, the latest
on brain and spinal cord plasticity across the lifespan, typical and atypical
cognitive functioning, and tips on how to use all that information to live a healthier
life. The author’s precise attention to detail in accurately describing the most
fundamental research in the field, combined with her wide-lens approach to
integrating this research with health and medicine applications, tell a
multidisciplinary and integrative story about plasticity in the brain and spinal cord
across the lifespan that has not been comprehensively told until now.
At a time when companies are profiting from making unfounded claims about
brain training programs, Marcano-Reik draws reasonable, scientifically supported
conclusions about the scientific evidence of brain and spinal cord plasticity
across the lifespan in relation to cognitive functioning, health and medicine. If you
been curious about brain training programs, then you owe it to yourself to read
this book.
As a cognitive psychologist who has lost my own mother to a brain tumor, I see
this book as not only a knowledgeable and artful description of current research,
but also a story of hope – of what we know to be possible within neuroscience
and what is on the horizon for future research. I will recommend this book to my
colleagues, use it in my graduate and undergraduate courses, and send a copy
to a special friend whose daughter is living with a brain tumor.
- Ashleigh M. Maxcey (Associate Professor of Psychology, Tennessee State University)

Click here to read the book review by - Dr. Ashleigh M. Maxcey, Associate Professor of Psychology, Tennessee State University

[1] Buonomano, D.V. and Merzenich, M.M., Cortical plasticity: from synapses to maps. Annual Review of Neuroscience, 1998.

21: p. 149-186.
[2] Kerr, A.L., Cheng, S.Y., and Jones, T.A., Experience-dependent neural plasticity in the adult damaged brain. Journal of Communication Disorders, 2011.

44(5): p. 538-548.
[3] Froemke, R.C., Merzenich, M.M., and Schreiner, C.E., A synaptic memory trace for cortical receptive field plasticity. Nature, 2007.

450: p.

[4] Feldman, D.E., Synaptic mechanisms for plasticity in neocortex. Annual Reviews of Neuroscience, 2009.

32: p. 33-55.
[5] Pita-Almenar, J.D., Ranganathan, G.N., and Koester, H.J., Impact of cortical plasticity on information signaled by populations of neurons in the cerebral cortex. Journal of Neurophysiology, 2011.

106(3): p. 1118-1124.
[6] Butz, M., Wörgötter, F., and van Ooyen, A., Activity-dependent structural plasticity. Brain Research Reviews, 2009.

60(2): p. 287-305.
[7] Kleim, J.A. and Jones, T.A., Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. Journal of Speech, Language, and Hearing Research, 2008.

51(1): p. 225-239.
[8] Thota, A.K., Watson, S.C., Knapp, E., Thompson, B., and Jung, R., Neurochemical control of locomotion in the rat. Journal of Neurotrauma, 2005.

22(4): p. 442-465.
[9] Dobkin, B.H., Activity-dependent learning contributes to motor recovery. Annals of Neurology, 1998.

44(2): p. 158-60.
[10] Fawcett, J.W., Spinal cord repair: from experimental models to human application. Spinal Cord, 1998.

36(12): p. 811-817.
[11] De Leon, R.D., Hodgson, J.A., Roy, R.R., and Edgerton, V.R., Retention of hindlimb stepping ability in adult spinal cats after the cessastion of step training. Journal of Neurophysiology, 1999.

81(1): p. 85-94.
[12] Rossignol, S., Locomotion and its recovery after spinal injury. Current Opinion in Neurobiology, 2000.

10(6): p. 708-716.
[13] Thompson, R.F., Spinal plasticity, in Spinal Cord Plasticity: Alterations in Reflex Function, M.M. Patterson and J.W. Grau, Editors. 2001, Kluwer: Boston.
[14] Wolpaw, J.R. and Tennissen, A.M., Activity-dependent spinal cord plasticity in health and disease. Annual Review of Neuroscience, 2001.

24: p. 807-843.
[15] Raineteau, O. and Schwab, M.E., Plasticity of motor systems after incomplete spinal cord injury. Nature Reviews Neuroscience, 2001.

2(4): p. 263-273.
[16] Dietz, V., Neuronal plasticity after a human spinal cord injury: positive and negative effects. Experimental Neurology, 2012.

235(1): p. 110-115.
[17] Onifer, S.M., Smith, G.M., and Fouad, K., Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it. Neurotherapeutics, 2011.

8(2): p. 283-293.
[18] Rosenzweig, E.S., Courtine, G., Jindrich, D.L., Brock, J.H., Ferguson, A.R., Strand, S.C., Nout, Y.S., Roy, R.R., Miller, D.M., Beattie, M.S., Havton, L.A., Bresnahan, J.C., Edgerton, V.R., and Tuszynski, M.H., Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience, 2010.

13(12): p. 1505-1510.
[19] Goldberger, M.E., Gorio, A., Murray, M., Development and Plasticity of the Mammalian Spinal Cord. Fidia Research Series. Vol. 3. 1986, New York, New York: Springer - Verlag.
[20] Garraghty, P.E. and Kaas, J.H., Functional reorganization in adult monkey thalamus after peripheral nerve injury. Neuroreport, 1991.

2(12): p. 747-750.
[21] Xerri, C., Plasticity of cortical maps: multiple triggers for adaptive reorganization following brain damage and spinal cord injury. Neuroscientist, 2012.

18(2): p. 133-148.
[22] Monsey, M.S., Ota, K.T., Akingbade, I.F., Hong, E.S., and Schafe, G.E., Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS One, 2011.

[23] Kealy, J. and Commins, S., The rat perirhinal cortex: a review of anatomy, physiology, plasticity, and function. Progress in Neurobiology, 2011.

93(4): p. 522-548.
[24] Skoe, E. and Kraus, N., Hearing it again and again: on-line subcortical plasticity in humans. PLoS One, 2010.

[25] Hebb, D.O., The organization of behavior: A neuropsychological theory. 1949, Wiley: New York.
[26] Morris, R.G., D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949. Brain Research Bulletin, 1999.

50(5-6): p. 437.
[27] Kolb, B., Synaptic plasticity and the organization of behaviour after early and late brain injury. Canadian Journal of Experimental Psychology, 1999.

53(1): p. 62-76.
[28] Citri, A. and Malenka, R.C., Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology Reviews, 2008.

33: p. 18-41.
[29] Turrigiano, G.G. and Nelson, S.B., Homeostatic plasticity in the developing nervous system. Nature Reviews Neuroscience, 2004.

5(2): p. 97-107.
[30] Hubel, D.H. and Wiesel, T.N., Receptive fields of single neurones in the cat's striate cortex. Journal of Physiology, 1959.

148(3): p. 574-591.
[31] Espinosa, J.S. and Stryker, M.P., Development and plasticity of the primary visual cortex. Neuron, 2012.

75(2): p. 230-249.
[32] Ganguly, K. and Mu-ming, P., Activity-dependent neural plasticity from bench to bedside. Neuron, 2013.

80(3): p. 729-741.
[33] Roffwarg, H.P., Muzio, J.N., and Dement, W.C., Ontogenetic development of the human sleep-dream cycle. Science, 1966.

152(3722): p. 604-619.
[34] Frank, M.G., Issa, N.P., and Stryker, M.P., Sleep enhances plasticity in the developing visual cortex. Neuron, 2001.

30: p. 275-287.
[35] Holcomb, E.M., Towns, S., Kamper, J.E., Barnett, S.D., Sherer, M., Evans, C., and Nakase-Richardson, R., The relationship between sleep-wake cycle disturbance and trajectory of cognitive recovery during acute traumatic brain injury. Journal of Head Trauma Rehabilitation, 2016.

31(2): p. 108-116.
[36] Marcano-Reik, A.J. and Blumberg, M.S., The corpus callosum modulates spindle-burst activity within homotopic regions of somatosensory cortex in newborn rats. European Journal of Neuroscience, 2008.

28(8): p. 1457-1466.
[37] Marcano-Reik, A.J., Prasad, T., Weiner, J.A., and Blumberg, M.S., An abrupt developmental shift in callosal modulation of sleep-related spindle bursts coincides with the emergence of excitatory-inhibitory balance and a reduction of somatosensory cortical plasticity. Behavioral Neuroscience, 2010.

124(5): p. 600-611.
[38] Marcano-Reik, A.J., Sleep-related activity and recovery of function in the somatosensory cortex during early development, PhD (Doctor of Philosophy) thesis in Interdisciplinary Studies in Neural Systems and Development, 2011, The University of Iowa, p. 1-87.
[39] Merzenich, M.M., Kaas, J.H., Wall, J., Nelson, R.J., Sur, M., and Felleman, D., Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience, 1983.

8(1): p. 33-55.
[40] Merzenich, M.M., Kaas, J.H., Wal, J.T., Sur, M., Nelson, R.J., and Felleman, D.J., Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys. Neuroscience, 1983.

10(3): p. 639-665.
[41] Merzenich, M.M., Nelson, R.J., Stryker, M.P., Cynader, M.S., Schoppmann, A., and Zook, J.M., Somatosensory cortical map changes following digit amputation in adult monkeys. The Journal of Comparative Neurology, 1984.

224(4): p. 591-605.
[42] Wall, J.T., Kaas, J.H., Sur, M., Nelson, R.J., Felleman, D.J., and Merzenich, M.M., Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans. The Journal of Neuroscience, 1986.

6(1): p. 218-233.
[43] Allard, T., Clark, S.A., Jenkins, W.M., and Merzenich, M.M., Reorganization of somatosensory area 3b representations in adult owl monkeys after digital syndactyly. Journal of Neurophysiology, 1991.

66(3): p. 1048-1058.
[44] Clark, S.A., Allard, T., Jenkins, W.M., Merzenich, M.M., Receptive fields in the body-surface map in adult cortex defined by temporally correlated inputs. Nature, 1988.

332(6163): p. 444-445.
[45] Schouenborg, J., Learning in sensorimotor circuits. Current Opinion in Neurobiology, 2004.

14(6): p. 693-697.
[46] Kolb, B., Recovery from early cortical damage in rats. I. differential behavioral and anatomical effects of frontal lesions at different ages of neural maturation. Behavioural Brain Research, 1987.

25(3): p. 205-220.
[47] Passingham, R.E., Perry, V.H., and Wilkinson, F., The long-term effects of removal of sensorimotor cortex in infant and adult rhesus monkeys. Brain 1983.

106(3): p. 675-705.
[48] Kolb, B. and Gibb, R., Sparing of function after neonatal frontal lesions correlates with increased cortical dendritic branching: a possible mechanism for the Kennard effect. Behavioural Brain Research, 1991.

43(1): p. 51-56.
[49] Finger, S., Margaret Kennard on sparing and recovery of function: a tribute on the 100th anniversary of her birth. Journal of the History of the Neurosciences, 1999.

8(3): p. 269-285.
[50] Kennard, M.A., Relation of age to motor impairment in man and in subhuman primates. Archives of Neurology & Psychiatry, 1940.

44(2): p. 377-397.
[51] Kennard, M.A., Cortical reorganization of motor function: studies on a series of monkeys of various ages from infancy to maturity. Archives of Neurology & Psychiatry, 1942.

48(2): p. 227-240.
[52] Kolb, B., Halliwell, C., and Gibb, R., Factors influencing neocortical development in the normal and injured brain, in Oxford Handbook of Developmental Behavioral Neuroscience, M.S. Blumberg, J.H. Freeman, and S.R. Robinson, Editors. 2010, Oxford University Press: New York, New York. p. 375-388.
[53] Kolb, B. and Cioe, J., Recovery from early cortical damage in rats, VIII. earlier may be worse: behavioural dysfunction and abnormal cerebral morphogenesis following perinatal frontal cortical lesions in the rat. Neuropharmacology, 2000.

39(5): p. 756-764.
[54] Kolb, B. and Cioe, J., Recovery from early cortical damage in rats. IX. Differential behavioral and anatomical effects of temporal cortex lesions at different ages of neural maturation. Behavioural Brain Research, 2003.

144(1-2): p. 67-76.
[55] Kolb, B. and Elliott, W., Recovery from early cortical damage in rats. II. Effects of experience on anatomy and behavior following frontal lesions at 1 or 5 days of age. Behavioural Brain Research, 1987.

26(1): p. 47-56.
[56] Kolb, B. and Gibb, R., Brain plasticity and recovery from early cortical injury. Developmental Psychobiology, 2007.

49(2): p. 107-118.
[57] Kolb, B., Petrie, B., and and Cioe, J., Recovery from early cortical damage in rats, VII. Comparison of the behavioural and anatomical effects of medial prefrontal lesions at different ages of neural maturation. Behavioural Brain Research, 1996.

79(1-2): p. 1-14.
[58] Kolb, B. and Tomie, J.A., Recovery from early cortical damage in rats. IV. Effects of hemidecortication at 1, 5 or 10 days of age on cerebral anatomy and behavior. Behavioural Brain Research, 1988.

28(3): p. 259-274.
[59] Kolb, B., Gibb, R., and Gorny, G., Cortical Plasticity and the Development of Behavior After Early Frontal Cortical Injury. Developmental Neuropsychology, 2000.

18(3): p. 423-444.
[60] Gramsbergen, A., Schwartze, P., Prechtl, H.F.R., The postnatal development of behavioral states in the rat. Developmental Psychobiology, 1970.

3(4): p. 267-280.
[61] Karlsson, K.Æ. and Blumberg, M.S., The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant rats. Behavioral Neuroscience, 2002.

116(5): p. 912-917.
[62] Seelke, A.M.H., Karlsson, K.Æ., Gall, A.J., and Blumberg, M.S., Extraocular muscle activity, rapid eye movements, and the development of active and quiet sleep. European Journal of Neuroscience, 2005.

22(4): p. 911-920.
[63] Blumberg, M.S. and Seelke, A.M.H, The form and function of infant sleep: from muscle to neocortex, in The Oxford Handbook of Developmental Behavioral Neuroscience, M.S. Blumberg, J.H. Freeman, and S.R. Robinson, Editors. 2010, Oxford University Press: New York. p. 391-423.
[64] Petersson, P., Granmo, M., Schouenborg, J., Properties of an adult spinal sensorimotor circuit shaped through early postnatal experience. Journal of Neurophysiology, 2004.

92(1): p. 280-288.
[65] Schouenborg, J., Action-based sensory encoding in spinal sensorimotor circuits. Brain Research Reviews, 2008.

57(1): p. 111-117.
[66] Holmberg, H. and Schouenborg, J., Postnatal development of the nociceptive withdrawal reflexes in the rat: a behavioural and electromyographic study. Journal of Physiology, 1996.

493(Pt 1): p. 239-252.
[67] Khazipov, R., Sirota, A., Leinekugel, X., Holmes, G.L., Ben-Ari, Y., Buzsáki, G., Early motor activity drives spindle-bursts in the developing somatosensory cortex. Nature, 2004.

432: p. 758-761.
[68] Minlebaev, M., Ben-Ari, Y., Khazipov, R., Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo. Journal of Neurophysiology, 2007.

97(1): p. 692-700.
[69] Hanganu, I.L., Ben-Ari, Y., Khazipov, R., Retinal waves trigger spindle bursts in the neonatal rat visual cortex. The Journal of Neuroscience, 2006.

26(25): p. 6728-6736.
[70] Hanganu, I.L., Staiger, J.F., Ben-Ari, Y., Khazipov, R., Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo. The Journal of Neuroscience, 2007.

27(21): p. 5694-5705.
[71] Van Wagenen, W.P. and Herren, R.Y., Surgical division of commissural pathways in the corpus callosum: relation to spread of an epileptic attack. Archives of Neurology & Psychiatry, 1940.

44(4): p. 740-759.
[72] Gazzaniga, M.S., Forty-five years of split-brain research and still going strong. Nature Reviews Neuroscience, 2005.

6(8): p. 653-659.
[73] Springer, S. and Deutsch, G., Left Brain, Right Brain: Perspectives from Cognitive Neuroscience. Fifth ed. Psychology, ed. R. Atkinson, G. Lindzey, and R. Thompson. 1999, New York, NY: W.H. Freeman and Company Worth Publishers. 406.
[74] Van Wagenen, W.P. and Herren, R.Y., Surgical division of commissural pathways in the corpus callosum: relation to spread of an epileptic attack. Archives of Neurology & Psychiatry, 1940.

44(4): p. 740-759.
[75] Gazzaniga, M.S., Forty-five years of split-brain research and still going strong. Nature Reviews Neuroscience, 2005.

6(8): p. 653-659.
[76] Mooshagian, E., Anatomy of the corpus callosum reveals its function. The Journal of Neuroscience, 2008.

28(7): p. 1535-1536.
[77] Bogen, J.E. and Vogel, P.J., Cerebral commissurotomy in man. Bulletin of The Los Angeles Neurological Society, 1962.

27(4): p. 169-172.
[78] Myers, R., Function of corpus callosum in interocular transfer. Brain, 1956.

79(2): p. 358-363.
[79] Lassonde, M. and Sauerwein, C., Neuropsychological outcome of corpus callosotomy in children and adolescents. Journal of Neurosurgical Sciences, 1997.

41(1): p. 67-73.
[80] Stigsdotter-Broman, L., Olsson, I., Flink, R., Rydenhag, B., and Malmgren, K., Long-term follow-up after callosotomy—A prospective, population based, observational study. Epilepsia, 2014.

55(2): p. 316-321.
[81] Park, M.S., Nakagawa, E., Schoenberg, M.R., Benbadis, S.R., and Vale, F.L., Outcome of corpus callosotomy in adults. Epilepsy and Behavior, 2013.

28(2): p. 181-184.
[82] Devesa, J., Díaz-Getino, G., Rey, P., García-Cancela, J., Loures, I., Nogueiras, S., Hurtado de Mendoza, A., Salgado, L., González, M., Pablos, T., and Devesa, P., Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report. International Journal of Molecular Sciences, 2015.

16(12): p. 30470-30482.
[83] Faden, A.I., Pharmacologic treatment of acute traumatic brain injury. The Journal of the American Medical Association, 1996.

276(7): p. 569-570.
[84] Miller, L.S., Colella, B., Mikulis, D., Maller, J., and Green, R.E.A., Environmental enrichment may protect against hippocampal atrophy in the chronic stages of traumatic brain injury. Fronties in Human Neuroscience, 2013.

7(506): p. 1-8.
[85] Saab, C.Y., Pain-related changes in the brain: diagnostic and therapeutic potentials. Trends in Neurosciences, 2012.

35(10): p. 629-637.
[86] Taub, E., Uswatte, G., and Elbert, T., New Treatments in Neurorehabilitation Founded on Basic Research. Nature Reviews Neuroscience, 2002.

3(3): p. 228-236.
[87] Nobunaga, A.I., Go, B.K., and Karunas, R.B., Recent demographic and injury trends in people served by the Model Spinal Cord Injury Care Systems. Archives of Physical Medicine and Rehabilitation, 1999.

80(11): p. 1372-1382.
[88] Anderson, J.M. and Schutt, A.H., Spinal injury in children: A review of 156 cases seen from 1950 through 1978. Mayo Clinic Proceedings, 1980.

55(8): p. 499-504.
[89] Carreon, L.Y., Glassman, S.D., and Campbell, M.J., Pediatric spine fractures: A review of 137 hospital admissions. Journal of Spinal Disorders and Techniques, 2004.

17(6): p. 477-482.
[90] d’Amato, C., Pediatric spinal trauma:injuries in very younf children. Clinical Orthopaedics & Related Research, 2005.

432: p. 34-40.
[91] Vogel, L. and DeVivo, M., Pediatric spinal cord injury issues: etiology, demographics, and pathophysiology. Topics in Spinal Cord Injury Rehabilitation, 1997.

3: p. 1-8.
[92] Vogel, L.C., Hickey, K.J., Klaas, S.J., and Anderson, C.J., Unique issues in pediatric spinal cord injury. Orthopaedic Nursing, 2004.

23(5): p. 300-308.
[93] Vavrek, R., Girgis, J., Tetzlaff, W., Hiebert, G., and Fouad, K., BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain, 2006.

129(Part 6): p. 1534-1545.
[94] Wernig, A., Müller, S., Nanassy, A., Cagol, E., Laufband therapy based on “rules of spinal locomotion” is effective in spinal cord injured persons. European Journal of Neuroscience, 1995.

7(4): p. 823-829.
[95] Wernig, A., Nanassy, A., and Müller, S., Laufband (treadmill) therapy in incomplete para-and tetraplegia. , in Spinal Plasticity: Alterations in reflex function, in Spinal Cord Plasticity: Alterations in Reflex Function, M.M. Patterson and J.W. Grau, Editors. 2001, Kluwer: Boston. P. 225-239.
[96] Barbeau, H., Nadeau, S., and Garneau, C., Physical determinants, emerging concepts, and training approaches in gait of individuals with spinal cord injury. Journal of Neurotrauma, 2006.

23(3-4): p. 571-585.
[97] Gómez-Pinilla, F., Ying, Z., Opazo, P., Roy, R., and Edgerton, V., Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. European Journal of Neuroscience, 2001.

13(6): p. 1078-1084.
[98] Gómez-Pinilla, F., Ying, Z., Roy, R., Molteni, R., and Edgerton, V., Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. Journal of Neurophysiology, 2002.

88(5): p. 2187-2195.
[99] Vaynman, S. and Gómez-Pinilla, F., License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabilitation and Neural Repair, 2005.

19(4): p. 283-295.
[100] Côté, M., Ménard, A., and Gossard, J., Spinal cats on the treadmill: Changes in load pathways. The Journal of Neuroscience, 2003.

23(7): p. 2789-2796.
[101] Côté, M. and Gossard, J., Step-training dependent plasticity in spinal cutaneous pathways. The Journal of Neuroscience, 2004.

24(50): p. 11317-11327.
[102] Bélanger, M., Drew, T., Provencher, J., and Rossignol, S., A comparison of treadmill locomotion in adult cats before and after spinal transection. Journal of Neurophysiology, 1996.

76(1): p. 471-491.
[103] Edgerton, V., Tillakaratne, N., Bigbee, A., de Leon, R., Roy, R., Plasticity of the spinal neural circuitry after injury. Annual Review of Neuroscience, 2004.

27: p. 145-167.
[104] Beattie, M., Hermann, G., Rogers, R., Bresnahan, J., Cell death in models of spinal cord injury. Progress in Brain Research, 2002.

137: p. 37-47.
[105] Whalley, K., O'Neill, P., and Ferretti, P., Changes in response to spinal cord injury with development: Vascularization, hemorrhage, and apoptosis. Neuroscience, 2006.

137(3): p. 821-832.
[106] Steeves, J., Cues from developmental models of spinal cord regeneration for the repair of the injured adult CNS, in Axonal Regeneration in the Central Nervous System, N.A. Ingoglia and M. Murray, Editors. 2002, Marcel Dekker: New York. p. 129-160.
[107] Ramer, L., Ramer, M., and Steeves, J., Setting the stage for functional repair of spinal cord injuries: A cast of thousands. Spinal Cord, 2005.

43(3): p. 134-161.
[108] Liebscher, T., Schnell, L., Schnell, D., Scholl, J., Schneider, R., Gullo, M., Fouad, K., Mir, A., Rausch, M., Kindler, D., Hamers, F., and Schwab, M., Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Advances in Neurology, 2005.

58(5): p. 706-719.
[109] Fawcett, J., Overcoming inhibition in the damaged spinal cord. Journal of Neurotrauma, 2006.

23(3-4): p. 371-383.
[110] Nicholls, J. and Saunders, N., Regeneration of immature mammalian spinal cord after injury. Trends in Neurosciences, 1996.

19(6): p. 229-234.
[111] Grau, J., Barstow, D., and Joynes, R., Instrumental learning within the spinal cord: I. Behavioral properties. Behavioral Neuroscience, 1998.

112(6): p. 1366-1386.
[112] Grau, J. and Joynes, R., Spinal cord plasticity and recovery of function, in Linking Animal Research and Human Psychological Health, M. Carroll and B. Overmier, Editors. 2001, American Psychological Association: Washington, D.C. p. 209-226.
[113] Crown, E., Ferguson, A., Joynes, R., and Grau, J., Instrumental learning within the spinal cord: II. evidence for central mediation. Physiology and Behavior, 2002.

77(2-3): p. 259-267.
[114] Varga, Z., Schwab, M., Nicholls, J., Myelin-associated neurite growth-inhibitory proteins and suppression of regeneration of immature mammalian spinal cord in culture. Proceedings of the National Academy of Sciences of the United States of America, 1995.

92(24): p. 10959-10963.
[115] Schnell, L. and Schwab, M., Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature, 1990.

343(6255): p. 269-272.
[116] Chen, M., Huber, A., van der Haar, M., Frank, M., Schnell, L., Spillman, A., Christ, F., Schwab, M., Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature, 2000.

403(6768): p. 434-439.
[117] Schwab, M., Nogo and axon regeneration. Current Opinion in Neurobiology, 2004.

14(1): p. 118-124.
[118] GrandPré, T., Li, S., and Strittmatter, S., Nogo-66 receptor antagonist peptide promotes axonal regeneration. Letters to Nature, 2002.

417(6888): p. 547-551.
[119] Savio, T. and Schwab, M., Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord. Proceedings of the National Academy of Sciences of the United States of America, 1990.

87(11): p. 4130-4133.
[120] Steeves, J., Cues from developmental models of spinal cord regeneration for the repair of the injured adult CNS, in Axonal Regeneration in the Central Nervous System, N.A. Ingoglia and M. Murray, Editors. 2002, Marcel Dekker: New York. p. 129-160
[121] Wolpaw, J. and Tennissen, A., Activity-dependent spinal cord plasticity in health and disease. Annual Review of Neuroscience, 2001.

24: p. 807-843.
[122] Krishnan, R.V., A theory on the lability and stability of spinal motoneurons soma size and induction of synaptogenesis in the adult spinal cord. International Journal of Neuroscience, 1983.

21(3-4): p. 279-292.
[123] Krishnan, R.V., Induction of plasticity in the isolated spinal cord in paraplegia. International Journal of Neuroscience, 1991.

56(1-4): p. 81-92.
[124] Krishnan, R.V., Relearning of locomotion in injured spinal cord: New directions for rehabilitation programs. International Journal of Neuroscience, 2003.

113(10): p. 1333-1351.
[125] Krishnan, R.V., Botulinum Toxin: from spasticity reliever to a neuromotor re-learning tool. International Journal of Neuroscience, 2005.

115(10): p. 1451-1467.
[126] Caldwell, D. and Werboff, J., Classical conditioning in newborn rats. Science, 1962.

136(3522): p. 1118-1119.
[127] Stelzner, D. Weber, E., and BryzGornia, W. , Sparing of function in developing spinal cord: Anatomical substrate, in Development and Plasticity of the Mammalian Spinal Cord, M.E. Goldberger, A. Gorio, and M. Murray, Editors. 1986, Fidia Research Series. Vol. 3. 1986, New York, New York: Springer - Verlag.
[128] Weber, E. and Stelzner, D., Behavioral effects of spinal cord transection in the developing rat. Brain Research, 1977.

125(2): p. 241-255.
[129] Stelzner, D., Choy, W., Nelson, D., and Stanley, G., Sparing of function in developing spinal cord: attempts to enhance recovery after adult injury by partial removal of supraspinal influence at birth. Plasticity of Motoneuronal Connections., ed. A. Wernig. 1991: Elsevier Science Publishers.
[130] Cramer, S.C., Repairing the Human Brain after Stroke: I. Mechanisms of Spontaneous Recovery. Annals of Neurology, 2008.

63(3): p. 272-287.
[131] Anderson, C., Vogel, L., Betz, R., and Willis, K., Overview of adult outcomes in pediatric-onset spinal cord injuries: Implications for transition to adulthood. The Journal of Spinal Cord Medicine, 2004.

27: p. 98-106.
[132] Grefkes, C. and Ward, N., Cortical reorganization after stroke: How much and how functional? The Neuroscientist, 2014.

20(1): p. 56-70.
[133] Chollet, F., DiPiero, V., Wise, R., Brooks, D., Dolan, R., and Frackowiak, R., The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Annals of Neurology, 1991.

29(1): p. 63-71.
[134] Marshall, R., Perera, G., Lazar, R., Krakauer, J., Constantine, R., DeLaPaz, R., Evolution of Cortical Activation During Recovery From Corticospinal Tract Infarction. Stroke, 2000.

31(3): p. 656-661.
[135] Rehme, A., Fink, G., Cramon, Y., Grefkes, C., The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal fMRI. Cerebral Cortex, 2011.

21(4): p. 756-768.
[136] Ambrosio, F., Boninger, M., Brubaker, C., Delitto, A., Wagner, W., Shields, R., Wolf, S., and Rando, T., Emergent themes from Second Annual Symposium on Regenerative Rehabilitation, Pittsburgh, Pennsylvania. Journal of Rehabilitation Research and Development, 2013.

50(3): p. 7-14.
[137] McHenry, C., Wu, J., and Shields, R., Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health. BioMed Central Research Notes, 2014.

7(334): p. 1-11.
[138] Ramachandran, V.S. and Rogers-Ramachandran, D., Synaesthesia in Phantom Limbs Induced with Mirrors. Proceedings of the Royal Society B: Biological Sciences, 1996.

263(1369): p. 377-386.
[139] Ramachandran, V.S. and Hirstein, W., The Perception of Phantom Limbs: The D. O. Hebb Lecture. Invited Review. Brain, 1998.

121: p. 1603-1630.
[140] Bavelier, D., Levi, D., Li, R., Dan, Y., and Hensch, T., Removing Brakes on Adult Brain Plasticity: From Molecular to Behavioral Interventions. The Journal of Neuroscience, 2010.

30(45): p. 14964-14971.
[141] Feng, J., Spence, I., and Pratt, J., Playing an Action Video Game Reduces Gender Differences in Spatial Cognition. Psychological Science, 2007.

18(10): p. 850-855.
[142] Farrow, S. and Reid, D., Stroke survivors' perceptions of a leisure-based virtual reality program. Technology and Disability, 2004.

16(2): p. 69-81.
[143] Hodgson, J., Roy, R., de Leon, R, Dobkin, B., and Edgerton, V., Can the mammalian lumbar spinal cord learn a motor task? Journal of the American College of Sports Medicine, 1994.

26(12): p. 1491-1497.
[144] de Leon, R., Hodgson, J., Roy, R., and Edgerton, V., Locomotor capacity attributable to step training versus spontaneous recovery following spinalization in cats. Journal of Neurophysiology, 1998.

79(3): p. 1329-1340.
[145] de Leon, R., Hodgson, J., Roy, R., and Edgerton, V., Full weight-bearing hindlimb standing following stand training in the adult spinal cat.. Journal of Neurophysiology, 1998.

80(1): p. 83-91.
[146] de Leon, R., Hodgson, J., Roy, R., and Edgerton, V., Retention of hindlimb stepping ability in adult spinal cats after the cessation of step training. Journal of Neurophysiology, 1999.

81(1): p. 85-94.
[147] Lovely, R., Gregor, R., Roy, R., and Edgerton, V., Weight-bearing hindlimb stepping in treadmill-exercised adult spinal cats. Brain Research, 1990.

514(2): p. 206-218.
[148] Timoszyk, W., de Leon, R., London, N., Roy, R., Edgerton, V., and Reinkensmeyer, D., The rat lumbosacral spinal cord adapts to robotic loading applied during stance. Journal of Neurophysiology, 2001.

88(6): p. 3108-3117.
[149] de Leon, R., Kubasak, M., Phelps, P., Timoszyk, W., Reinkensmeyer, D. Roy, R., and Edgerton, V., Using robotics to teach the spinal cord to walk. Brain Research Reviews, 2002.

40(1-3): p. 267-273.
[150] Collazos-Castro, J., López-Dolado, E., and Nieto-Sampedro, M., Locomotor deficits and adaptive mechanisms after thoracic spinal cord contusion in the adult rat. Journal of Neurotrauma, 2006.

23(1): p. 1-17.
[151] Harkema, S., Neural plasticity after human spinal cord injury: application of locomotor training to the rehabilitation of walking. Neuroscientist, 2001.

7(5): p. 455-468.
[152] Harkema, S., Hurley, S., Patel, U., Requejo, P., Dobkin, B., and Edgerton, V., Human lumbosacral spinal cord interprets loading during stepping. Journal of Neurophysiology, 1997.

77(2): p. 797-811.
[153] Winchester, P. and Querry, R., Robotic orthoses for body weight-supported treadmill training. Physical Medicine and Rehabilitation Clinics of North America, 2006.

17(1): p. 159-172.
[154] Steeves, J., Cues from developmental models of spinal cord regeneration for the repair of the injured adult CNS, in Axonal Regeneration in the Central Nervous System, N.A. Ingoglia and M. Murray, Editors. 2002, Marcel Dekker: New York. p. 129-160
[155] Staup, M.S. and Stehouwer, D.J., Ontogeny of L-DOPA-induced locomotion: Expression of c-Fos in the brainstem and basal ganglia of rats. Brain Research, 2005.

1068(1): p. 56-64.
[156] Kleim, J., Lussnig, E., Schwarz, E., Comery, T., and Greenough, W., Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning. The Journal of Neuroscience, 1996.

16(14): p. 4529-4535.
[157] Kaczmarek, L., c-Fos in learning: Beyond the mapping of neuronal activity, in Handbook of Chemical Neuroanatomy Vol. 19: Immediate Early Genes and Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction. 2002, Elsevier Science p. 189-215.
[158] Ahn, S., Guu, J., Tobin, A., Edgerton, V., and Tillakaratne, N., Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats. Spinal Cord, 2006.

44: p. 547-559.
[159] Nicholls, J. and Saunders, N., Regeneration of immature mammalian spinal cord after injury. Trends in Neurosciences, 1996.

19(6): p. 229-234.
[160] Bolte Taylor, J., My Stroke of Insight: A Brain Scientist's Personal Journey. 2006, New York, New York: Viking.
[161] De Salvo, S., Caminiti, F., Bonanno, L., De Cola, M., Corallo, F., Rifici, C., Bramanti, P., and Marino, S., Neurophysiological assessment for evaluating residual cognition in vegetative and minimally conscious state patients: a pilot study. Functional Neurology, 2015.

30(4): p. 237-244.
[162] Woodman, G.F., Viewing the dynamics and control of visual attention through the lens of electrophysiology. Vision Research, 2013.

80: p. 7-18.
[163] Woodman, G.F., A brief introduction to the use of event-related potentials in studies of perception and attention. Attention, Perception, & Psychophysics, 2010.

72(8): p. 2031-2046.
[164] Luck, S.J., An introduction to the event-related potential technique. 2005, Cambridge, MA.: MIT Press.
[165] Maxcey-Richard, A.M. and Hollingworth, A., The strategic retention of task-relevant objects in visual working memory. Journal of Experimental Psychology, 2013.

39(3): p. 760-772.
[166] Berchtold, N., Castello, N., and Cotman, C., Exercise and time-dependent benefits to learning and memory. Neuroscience, 2010.

167(3): p. 588-597.
[167] Marchant, N., Reed, B., Sanossian, N., Madison, C., Kriger, S., Dhada, R., Mack, W., DeCarli, C., Weiner, M., Mungas, D., and Chui, H., The Aging Brain and Cognition: Contribution of Vascular Injury and Aβ to Mild Cognitive Dysfunction. Journal of the American Medical Association Neurology, 2013.

70(4): p. 488-495.
[168] Kim, S., Uhlmann, R., Appelbaum, P., Knopman, D., Kim, H., Damschroder, L., Beattie, E., Struble, L., and De Vries, R., Deliberative assessment of surrogate consent in dementia research. Alzheimer’s & Dementia, 2010.

6(4): p. 342-350.
[169] Bekris, L., Yu, C., Brid, T., and Tsuang, D., Review article: Genetics of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 2010.

23(4): p. 213-227.
[170] Davatzikos, C., Fan, Y., Wu, X., Shen, D., and Resnick, S., Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging. Neurobiology of Aging, 2008.

29(4): p. 514-523.
[171] Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., Iwatsubo, T., Jack, C.R., Kaye, J., Montine, T.J., and Park, D.C., Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer’s & Dementia, 2011.

7(3): p. 280-292.
[172] Alzheimer’s Association. [Cited 2011].
[173] Woodard, J., Seidenberg, M., Nielson, K., Smith, C., Antuono, P., Durgerian, S., Guidotti, L., Zhang, Q., Butts, A., Hantke, N., Prediction of cognitive decline in healthy older adults using fMRI. Journal of Alzheimer’s Disease, 2010.

21(3): p. 871-885.
[174] Buckholtz, N.S., Perspective: in search of biomarkers. Nature, 2011.

475(7355): p. S8.
[175] Clayton, E.W., Ethical, legal, and social implications of genomic medicine. New England Journal of Medicine, 2003.

349(6): p. 562-569.
[176] Ashida, S., Koehly, L., Roberst, J., Chen, C., Hiraki, S., and Green, R., The role of disease perceptions and results sharing in psychological adaptation after genetic susceptibility testing: the REVEAL Study. European Journal of Human Genetics, 2010.

18(12): p. 1296-1301.
[177] Gleichgerrcht, E., Ibáñez, A., Roca, M., Torralva, T. and Manes, F., Decision-making cognition in neurodegenerative diseases. Nature Reviews Neurology, 2010.

6(11): p. 611-623.
[178] Bluman, L.G., Rimer, B.K., Sterba, K.R., Lancaster, J., Clark, S., Borstelmann, N., Iglehart, J.D., and Winer, E.P., Attitudes, knowledge, risk perceptions and decision-making among women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2 and their spouses. Psycho-Oncology, 2003.

12(5): p. 410-427.
[179] Hamilton, R.J., Bowers, B.J., and Williams, J.K., Disclosing genetic test results to family members. Journal of Nursing Scholarship, 2005.

37(1): p. 18-24.
[180] Stoffel, E.M., Ford, B., Mercado, R.C., Punglia, D., Kohlmann, W., Conrad, P., Blanco, A., Shannon, K.M., Powell, M., Gruber, S.B., and Terdiman, J., Sharing genetic test results in Lynch syndrome: communication with close and distant relatives. Clinical Gastroenterology and Hepatology, 2008.

6(3): p. 333-338.
[181] Mihaescu, R., Detmar, S.B., Cornel, M.C., van der Flier, W.M., Heutink, P., Hol, E.M., Rikkert, M.G., van Duijn, C.M., and Janssens, A.C.J.W., Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives. Journal of Alzheimer’s Disease, 2010.

20(4): p. 967-980.
[182] Kim, S.Y., The ethics of informed consent in Alzheimer disease research. Nature Reviews Neurology, 2011.

7(7): p. 410-414.
[183] Arribas-Ayllon, M., The ethics of disclosing genetic diagnosis for Alzheimer's disease: do we need a new paradigm? British Medical Bulletin, 2011.

100(1): p. 7-21.
[184] Gomar, J.J., Bobes-Bascaran, M.T., Conejero-Goldberg, C., Davies, P., Goldberg, T.E., and Alzheimer's Disease Neuroimaging Initiative, 2011. Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's Disease Neuroimaging Initiative. Archives of General Psychiatry, 2011.

68(9): p. 961-969.
[185] Lerman, C., Croyle, R.T., Tercyak, K.P. and Hamann, H., Genetic testing: psychological aspects and implications. Journal of Consulting and Clinical Psychology, 2002.

70(3): p. 784-797.
[186] Brewster, P.W., Melrose, R.J., Marquine, M.J., Johnson, J.K., Napoles, A., MacKay-Brandt, A., Farias, S., Reed, B. and Mungas, D., Life experience and demographic influences on cognitive function in older adults. Neuropsychology, 2014.

28(6): p. 846-858.
[187] Hanna-Pladdy, B. and MacKay, A., The Relation Between Instrumental Musical Activity and Cognitive Aging. Neuropsychology, 2011.

25(3): p. 378-386.
[188] Lenehan, M.E., Summers, M.J., Saunders, N.L., Summers, J.J., Ward, D.D., Ritchie, K. and Vickers, J.C., Sending Your Grandparents to University Increases Cognitive Reserve: The Tasmanian Healthy Brain Project. Neuropsychology, 2015.

Advance online publication.
[189] Leung, I.H., Walton, C.C., Hallock, H., Lewis, S.J., Valenzuela, M. and Lampit, A., Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology, 2015.

85(21): p. 1843-1851.
[190] American Psychological Association. Available from:
[191] Glicksman, E., Catching autism earlier: a flood of new research is advancing our understanding of autism and highlighting the need for earlier interventions. Monitor on Psychology, 2012.

57(9): p. 56.
[192] Centers for Disease Control and Prevention. Available from:
[193] Autism Speaks. Available from:
[194] Diagnostic and Statistical Manual of Mental Disorders, 5th Edition: DSM-5. 2013, Arlington, VA: American Psychiatric Publishing.
[195] Kandalaft, M.R., Didehbani, N., Krawczyk, D.C., Allen, T.T. and Chapman, S.B., Virtual reality social cognition training for young adults with high-functioning autism. Journal of Autism and Developmental Disorders, 2013.

43(1), p. 34-44.
[196] Mickley, G., Kenmuir, C., McMullen, C., Yocom, A., Valentine, E., Dengler-Crish, C., Weber, B., Wellman, J., and Remmers-Roeber, D., Dynamic processing of taste aversion extinction in the brain. Brain Research, 2004.

1016(1): p. 79-89.
[197] Hillman, C., Erickson, K., and Kramer, A., Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews Neuroscience, 2008.

9(1): p. 58-65.
[198] White, L.J. and Castellano, V., Exercise and brain health—Implications for Multiple Sclerosis. Sports medicine, 2008.

38(3): p. 179-186.
[199] Ontaneda, D., Sakaie, K., Lin, J., Wang, X., Lowe, M.J., Phillips, M.D., and Fox, R.J., Identifying the start of Multiple Sclerosis injury: a serial DTI study. Journal of Neuroimaging, 2014.

24(6): p. 569-576.
[200] Cholerton, B., Larson, E.B., Quinn, J.F., Zabetian, C.P., Mata, I.F., Keene, C.D., Flanagan, M., Crane, P.K., Grabowski, T.J., Montine, K.S., and Montine, T.J., Precision medicine: clarity for the complexity of dementia. The American Journal of Pathology, 2016.

186(3): p. 500-506.
[201] Collins, F. and Varmus, H., A new initiative on precision medicine. New England Journal of Medicine, 2015.

372(9): p. 793-795.
[202] Presidential Commission for the Study of Bioethical Issues: Gutmann, A.W., Wagner, J.W., Ali, Y., Allen, A.L., Arras, J.D., Atkinson, B.F., Farahany, N.A., Garza, A.G., Grady, C., Hauser, S.L., and Kucherlapati, R.S., Privacy and progress in whole genome sequencing. 2012. Washington, D. C. [online].
[203] Mirnezami, R., Nicholson, J., and Darzi, A., Preparing for precision medicine. New England Journal of Medicine, 2012.

366(6): p. 489-491.
[204] Insel, T., The NIMH research domain criteria (RDoC) project: precision medicine for psychiatry. The American Journal of Psychiatry, 2014.

171(4): p. 395-397.
[205] Casas, R.N., Gonzales, E., Aldana-Aragón, E., Lara-Muñoz, M.D.C., Kopelowicz, A., Andrews, L., and López, S.R., Toward the early recognition of psychosis among Spanish-speaking adults on both sides of the US–Mexico border. Psychological Services, 2014.

11(4): p. 460-469.
[206] Kandel, E., A new intellectual framework for psychiatry. The American Journal of Psychiatry, 1998.

155(4): p. 457-469.
[207] Presidential Commission for the Study of Bioethical Issues. Gray matters: Integrative approaches for neuroscience, ethics, and society. 2014. Washington, D. C. [online].

The book is written for a diverse audience of scholars and students interested in the brain, behavior, cognition, and health. This book, as the title suggests, provides a very unique interdisciplinary and integrative approach. For this reason, this book crosses and transcends multiple disciplines and interdisciplinary programs: neuroscience, psychosocial studies, health and medicine, and genetics and environmental studies. The book provides an intersectional meeting point for scholars interested in the brain (natural sciences) and behavior (social sciences). It also addresses persistent, enduring questions such as the impact of nature versus nurture on development and behavior.

The book is relevant for scholars studying brain, spinal cord, plasticity, behavior, and cognition in the academic fields of neuroscience, neurology, psychology (including social psychology, clinical psychology, developmental psychology, neuropsychology, sensation and perception), psychiatry, biology, ethics, genetics, health and medicine. In addition to undergraduate-, graduate- and professional-level scholars, this book will appeal to practitioners of medicine and other health care professionals providing services for individuals diagnosed with conditions or diseases involving the brain or cognitive capacity (e.g., epilepsy, autism spectrum disorders (ASDs), Alzheimer’s disease). The findings and examinations provided throughout this book can be applied to graduate and undergraduate courses in neuroscience, psychology, biology, ethics, health, and medicine.

This work will also appeal to a much wider audience, including healthcare consultants and analysts, allied health professionals, patients and patient advocates, patient- or disease-advocacy organizations, and any reader who is interested in learning more about the ways in which the brain develops in response to behavior and experience and gives rise to higher, complex processes (e.g., cognition) and health. In addition, this book will also appeal to a much more general and wide reader audience for anyone interested in learning more about how to achieve, maintain, and sustain physical (brain) and mental (psychological) health.

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