Botulinum Toxin in Dermatology: A Clinical Overview

Anna Campanati
Dermatological Unit, Dept. of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy

Series: Dermatology – Laboratory and Clinical Research
BISAC: MED017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Even those clinicians who feel themselves far from esthetic dermatology now recognize that BoNT-A is an extraordinary tool in their therapeutic armamentarium for treating complex disorders such as focal idiopathic hyperhidrosis. This has opened a therapeutic scenario for a group of patients very difficult to treat previously. Since the introduction of BoNT-A in the dermatological therapeutic armamentarium, in 1990, things have changed to the point that any dermatologist should now have knowledge of BoNT-A basics, and the practicalities of BoNT-A vial reconstitution and injection. Moreover, in the last years, a widespread availability of multiple different commercially available forms of BoNT-A has been for sale, thus the clinicians must now really know and consider the advantages and disadvantages of the different available products. These would include dosing/duration, immunogenicity, and spread of effect.

What has not changed over the years is the safety profile of BoNT-A. The knowledge regarding its side effects and complications have greatly increased, confirming that, despite the attempts of some individuals to assert otherwise, BoNT-A remains one of the safest forms of treatment available to us as physicians. This edited collection provides a comprehensive practical guide on the use of botulinum toxin in several dermatological disorders, including focal idiopathic, axillary, palmar and plantar, craniofacial or segmental hyperhidrosis, chrono-aging, hidradenitis, and gives some suggestion on the use of BoNT-A for the treatment of several orphan skin diseases, not responding to conventional treatments like benign Hailey-Hiley disease, lichen simplex, osmidrosis. Using clear explanations, simple line drawings, diagrams and clinical pictures, it provides suggestions to improve practical knowledge on the use of BTX-A in dermatology.

Hot topics include practical information for clinicians regarding the correct counseling of the patients to be treated; methods and ready to use tests to select patients to be treated; the optimal dosage and dilution according to the site of injection and the indication of use; the relevant injection sites for each condition; the correct technique of injection in the different areas of body surface; comparative dosage tables for the various formulations of toxin used; how to manage and prevent side effects related to the use of BoNT-A; common pitfalls and how to optimize outcomes; timing for the follow-up of treated patients. The authors hope that this book may be a starting point for the use of a drug that is still growing, and a useful tool for those clinicians who want to improve their knowledge about the use of BoNT-A in dermatology.
(Imprint: Nova Biomedical)

Preface

List of Authors

Chapter 1 - History and Mechanism of Action of Botulinum Toxin (pp. 1-12)
Giulia Ganzetti, MD and Annamaria Offidani, MD (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University)

Chapter 2 - Botulinum Toxin in Focal Idiopatic Hyperhidrosis (pp. 13-34)
Katia Giuliodori, MD and Annamaria Offidani, MD (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University)

Chapter 3 - Botulinum Toxin Type A for Aesthetic Use (pp. 35-60)
Simona De Blasio, MD, and Annamaria Offidani, MD (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University)

Chapter 4 - Hidradenitis Suppurativa: How to Treat with BoNT-A (pp. 61-76)
Emanuela Martina, MD and Annamaria Offidani, MD (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University)

Chapter 5 - Botulinum Toxin in Dermatology: What‟s New? (pp. 77-94)
Anna Campanati, MD and Annamaria Offidani, MD (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University)

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