Blood Pressure Variability and Heart Rate Variability as New Risk Factors of Cardiovascular Disease among Apparently Healthy People


Authors: J. Siegelova, M. Pohanka, J. Dusek, L. Dunklerova, A. Havelkova, P. Dobsak, and G. Cornelissen
Page Range: 177-182
Published in: World Heart Journal, 15#3 (2023)
ISSN: 1556-4002

Table of Contents


Using ambulatory blood pressure monitoring (ABPM), Franz Halberg and Germaine Cornelissen showed the need to account for day-to-day changes of blood pressure (BP) and heart rate (HR) and the necessity for circadian assessment of the hour-to-hour variability in cardiovascular parameters. Together with the Halberg Chronobiology Center at the University of Minnesota, we participate in the international project on the BIOsphere and the COSmos (BIOCOS). This presentation adds new results to the BIOCOS project [1, 2]. In the guidelines for diagnoses of hypertension, fixed limits of 140/90 mmHg (systolic/diastolic BP) were used to diagnose hypertension in all adults 18 years and older. The circadian rhythm in BP was thought to primarily reflect the rest-activity schedule rather than being partly endogenous [2]. While this is no longer the case, ABPM is still restricted to “special cases”, often limited to 24 hours. Evidence is presented herein for the need to routinely screen for BP and HR variability, and for continued monitoring in patients in need of treatment. According to a consensus meeting held at St. Anna Hospital, Masaryk Univesity, Brno, Czech Republic in 2008, Franz Halberg with Germaine Cornelissen, Thomas Kenner, Bohumil Fiser, Jarmila Siegelova and others proclaimed Vascular Variability Disorders. Vascular Variability Disorders (VVDs) – MESOR hypertension, circadian hyper-amplitude-tension (CHAT), excessive pulse pressure, deficient heart rate variability and deviation of the circadian period or phase from norms – are best determined based on 7-day/24-hour ABPM [3-9]. The 24-hour BP profile tends to weaken with advancing age. This paper aims to assess 24-hour profiles of BP and HR, and their variation as a function of age, based on 7-day/24-hour ABPM.

Keywords: blood pressure, circadian rhythm, 7-day/24-hour ambulatory blood pressure monitoring, clinically healthy people

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