Bladder Cancer: Research Advances and Clinical Challenges

Ja Hyeon Ku, M.D., Ph.D. (Editor)
Department of Urology, Seoul National University Hospital, Yongon Dong, Jongno Ku, Seoul, Korea

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Bladder cancer is the fifth most common cancer with an estimated 60,490 new cases and 12,240 deaths expected for 2017 in the US alone. The diagnosis and treatment of bladder cancer in the current era is in the midst of a revolution. Recent research has focused on the evaluation of genetic markers to provide diagnostic and prognostic information in bladder cancer. In recent years, systemic therapies using a variety of immunotherapeutic strategies have evolved for the treatment of urothelial carcinoma.
Bladder Cancer: Research Advances and Clinical Challenges is a textbook on bladder cancer written by leading world experts in the field. This new book presents the latest research in this field. It has ten chapters that discuss a wide variety of the most important topics, including: cancer stem cells; molecular biomarkers; cancer detection and monitoring; clinical prognostication; immune checkpoint inhibitors; etc. It will equally be appreciated by urologists as well as scientists. The editor hopes that this book will offer the most contemporary and useful information for specialists involved in bladder cancer.

Preface

Chapter 1. Recent Advancements towards Molecular Insights and Therapeutic Targets in Bladder Cancer
(Minal Garg, Department of Biochemistry, University of Lucknow, Lucknow, India)

Chapter 2. The Emerging Role of miRNA in Guiding Therapy for Bladder Cancer
(Kristian Stensland, MD, Heba Fanous, MD, Jared Schober, MD, Marc Calabrese, MD, Travis Sullivan, and Kimberly Rieger-Christ, PhD, Department of Urology, Lahey Hospital and Medical Center, Burlington, MA, USA)

Chapter 3. The Recent Molecular Landscape of Bladder Cancer
(Jung Jun Kim and Jong Jin Oh, Department of Urology, Seoul National University Bundang Hospital, Seonganam, South Korea)

Chapter 4. Biomarkers in Bladder Cancer
(Fernando Luiz Affonso Fonseca, Beatriz da Costa Aguiar Alves, Débora Faria Pereira, Flávia de Sousa Gehrke, Thaís Moura Gascón, and Glaucia Raquel Luciano da Veiga, Laboratório de Análises Clínicas, Faculdade de Medicina do ABC (FMABC), Santo André/SP, Brazil)

Chapter 5. Biological Markers in Muscle-Invasive Bladder Cancer
(Yun-Sok Ha and Tae-Hwan Kim, Department of Urology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea)

Chapter 6. Development of a Novel, Inexpensive, Rapid, and Accurate Liquid Biopsy Fluorescence in Situ Hybridization Test for Bladder Cancer Detection and Monitoring
(Joan Aurich-Costa, Rima Aljundi, Jacqueline Cammuso, Joe Scire, Dylan Tully, Mike Hahn, Mike Malanga, Jason Hafron, Kenneth Kernen and Robert Di Loreto, Cellay Inc. Cambridge, MA, US)

Chapter 7. Bladder Cancer Detection and Surveillance: An Assessment of Urine-Based Biomarkers
(Huixiang Yang, Department of Andrology, Xingtai Infertility, Reproduction and Genetics Specialist Hospital, Hebei, China)
Chapter 8. The Importance of Non-Muscle Invasive Bladder Cancer Risk Stratification
(Satoru Muto, Takesi Ieda and Shigeo Horie, Department of Advanced Informatics for Genetic Disease, Juntendo University, Graduate School of Medicine, Tokyo, Japan, and others)

Chapter 9. Downstaging by Transurethral Resection of a Bladder Tumor in Patients with Muscle-Invasive Bladder Cancer Might Not Provide a Protective Effect on Prognosis after Radical Cystectomy
(Dalsan You, In Gab Jeong, Bumsik Hong, Yong Mee Cho, Jun Hyuk Hong, Hanjong Ahn, and Choung-Soo Kim, Departments of Urology and Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea)

Chapter 10. The Current Perspective on Systemic Immunotherapy Based on Immune Checkpoint Inhibition in Metastatic Urothelial Carcinoma
(Hyung Suk Kim and Ja Hyeon Ku, Department of Urology, Dongguk University Ilsan Medical Center, Gyeonggi-do, Korea, and others)

Index

Keywords: Bladder cancer, research, genetic markers, management

Audience: Urologists including residents and fellows, basic investigators who are working on bladder cancer

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