Biological Responses, Monitoring and Protection from Radiation Exposure

K.P. Mishra, PhD (Editor)
Vice Chancellor, Nehru Gram Bharti University, Allahabad, India

Series: Nuclear Materials and Disaster Research
BISAC: SCI058000

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This book deals with urgent and timely issues related to radiation health effects and protection that are examined by both young researchers as well as experts. The book is organized into three major sections: biological responses, population monitoring and approaches to protection from radiation exposure. Contributors have provided state of the art research in their respective chapters. Radiation action produces damage to multiple targets in the exposed cells or human body and understanding of molecular mechanisms of the underlying processes becomes central to the monitoring of effects and health consequences of radiation exposure.

Many experts have highlighted the outcome of epidemiological studies on human populations in high background radiation areas in different locations around the world as well as consequences and scopes for mitigating radiation health effects after radiation accidents such as Chernobyl in Ukraine and the Fukushima Daiichi Accident in Japan. This book also provides important direction for treatment of radiation for exposed victims. In the concluding chapters, contributors have provided new approaches for protection against ionizing radiation exposure.

This book contains rich content on basic aspects of radiation induced cellular response which may give deeper insight to beginners in research, teaching, industry and regulatory authorities for basic understanding of radiobiological processes and molecular mechanisms. The book will prove an authentic reference source for updates in radiation science. It is hoped that students, teachers, experts, safety officers, regulatory officials and policy-makers will find the book handy for gaining a broad view of radiation damage to biological systems, monitoring health consequences and for new approaches in developing effective protection against radiation exposure.

(Imprint: Nova)

Preface

Chapter 1 - Radiation-Induced Damage to Cellular DNA: Recent Aspects and Perspectives (pp. 1-22)
Jean Cadet and J. Richard Wagner (Univ. Grenoble Alpes, INAC, Grenoble, France, and others)

Chapter 2 - Stem Cells and Regeneration of Irradiated Tissues (pp. 23-32)
Mohi Rezvani, PhD (Reader Emeritus, Faculty of Clinical Medicine, University of Oxford, UK)

Chapter 3 - Differential Radiosensitivity of Bystander Normal and Tumor Cells and Its Implications in Cancer Radiotherapy (pp. 33-40)
Badri Narain Pandey (Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India)

Chapter 4 - Dose Rate: A Critical Factor in Determining the Cancer Risk of Radiation at an Environmental Level (pp. 41-52)
Hiroshi Tanooka (Radiation Effects Association, Tokyo, Japan, and others)

Chapter 5 - Radiation Risk from Medical X-Ray Devices, Interventional Radiology and Mammography (pp. 53-68)
S. P. Mishra and M. L. B. Bhatt (Department of Radiation Oncology, Prof of Radiation Oncology, Lohia Institute of Medical Sciences, Gomti Nagar, Lucknow, Uttar, Pradesh, India)

Chapter 6 - Epidemiology and Molecular Studies in Cerebrovascular Disease at the Late Period after Radiation Exposure in Chernobyl (pp. 69-84)
D. Bazyka, V. Buzunov, I. Ilyenko and K. Loganovsky (National Research Center for Radiation Medicine (RCRM), Kyiv, Ukraine)

Chapter 7 - Radiation Monitoring and Radioprotection in Nuclear Disaster: Lessons from Fukushima Daiichi Nuclear Power Plant Accident (pp. 85-90)
Yoshihisa Matsumoto (Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology)

Chapter 8 - Social and Health Effects of Fukushima Nuclear Accident on Residents and Evacuees (pp. 91-106)
Suminori Akiba, Athira Nandakumar and Futoshi Uwatoko (Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan)

Chapter 9 - The Challenging Issue of High Levels of Background Radiation and Cancer Incidence in Ramsar, Iran (pp. 107-114)
S. M. J. Mortazavi and K. P. Mishra (Shiraz University of Medical Sciences, Iran)

Chapter 10 - The Effects of Electron Beam and Gamma Irradiation Conducted in Air on the Property Behaviour of Semicrystalline Medical Grade Polyurethane (pp. 115-148)
Kieran A. Murray, James E. Kennedy, Brian McEvoy, Olivier Vrain, Damien Ryan, Richard Cowman, and Clement L. Higginbotham (Materials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co. Westmeath, Ireland, and others)

Chapter 11 - Treatment of Acute Radiation Syndromes with Transplantation of Bone Marrow-Derived Mesenchymal Stromal Cells (pp. 149-164)
Claudia Lange, Rudolph Reimer, Jozef Zustin and Bärbel Brunswig-Spickenheier (Clinic for Stem Cell Transplantation, Dept. Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany)

Chapter 12 - Herbal Based Strategy for Radioprotection against Radiation Exposure (pp. 165-174)
Prabodha Kumar Meher, Prerna Sharma and Kaushala Prasad Mishra (Division of Life Sciences, Research Center, Nehru Gram Bharati University, Allahabad, India, and others)

Chapter 13 - Role of Antioxidants in Cellular Response to Ionizing Radiation (pp. 175-192)
Renu Dayal, Amrita Singh and K. P. Mishra (Division of Life Sciences, Research Centre, Nehru Gram Bharati University, Allahabad)

Chapter 14 - Role of Topoisomerase IB on Damage Induced by Ionizing Radiation (pp. 193-206)
Zeenat Jahan, Marina Cerreto, Giorgia Aversa, Stefano Rufini, Alessandro Desideri and Anna Giovanetti (Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, Rome, Italy, and others)

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