Biological and Non-Biological Therapy in Pemphigus: An Updated Therapeutic Guide

Andrés Tirado-Sánchez
Department of Dermatology, Hospital General de Mexico and Instituto Mexicano del Seguro Social, Mexico

Series: Dermatology – Laboratory and Clinical Research
BISAC: SCI013040




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The main objective in treating pemphigus vulgaris is to control the disease, prevent relapses, and avoid adverse events associated with the prolonged use of steroids and immunosuppressive agents. Finding the most effective steroid-sparing agent has formed much of the focus of recent research. Systemic corticosteroids remain the gold standard for pemphigus vulgaris. In this book, the reader will have a complete view of this group of life-threatening diseases through direct images, tables and text. This book is not only of interest to dermatologists, but for all those health professionals whom at some point in their lives have tried or at least had the opportunity to see a patient with these diseases. This book is obviously also intended for those who have experienced first hand pemphigus vulgaris. This book is also a suitable medium for understanding the pemphigus group. Residents and researchers in dermatology and close disciplines can use the book as a quick reference guide when dealing with these patients.

This book will help both dermatologists and non-dermatology physicians for treating each disease practically. Each chapter reviews the current literature of treatments for each disease, rates disease severity, and provides guidelines for the use of available medications. This book will help guide clinicians in carrying out suitable treatments based on the severity. The author aims to provide a quick study guide for students and a reference for physicians who practice treating these types of patients. The author hopes the reader enjoys reading this book as much as he did composing it. (Imprint: Nova Biomedical)

Part 1. Physiological and Pathological Backround

Chapter 1. The Biology of the Epidermis. The Basics.

Chapter 2. The Immune System in Normal Skin and in Pemphigus Skin

Part 2. Ethiopathogenesis of Pemphigus

Chapter 3. Desmosomal Protein Targets in Pemphigus

Chapter 4. Apoptosis and Acantholysis in Pemphigus. The Concept of Apoptolysis

Chapter 5. Genetic and Environmental Risk Factors of Pemphigus

Part 3. Epidemiology

Chapter 6. Epidemiology of Pemphigus

Part 4. Clinical Presentation of Pemphigus

Chapter 7. Clinical Presentation of Pemphigus Vulgaris

Chapter 8. Clinical Presentation of Pemphigus Foliaceus

Chapter 9. Paraneoplastic Pemphigus

Chapter 10. IgA Pemphigus

Part 5. Diagnostic Tests

Chapter 11. Diagnosis of Pemphigus

Chapter 12. ELISA Test and Immunoblotting

Chapter 13. Electron Microscopy and Immunoelectron Microscopy

Part 6. General Management of Pemphigus

Chapter 14. Non-biological Therapy

Chapter 15. Biological Therapy

Part 7. Detailed Management of Pemphigus. Non-Biological Therapy

Chapter 16. Costicosteroids

Chapter 17. Treatment and Prevention of Glucocorticoid-Induced Osteoporosis

Chapter 18. Prevention and Therapy of Steroid-Induced Diabetes

Chapter 19. Prevention and Treatment of Infections

Chapter 20. Azathioprine

Chapter 21. Mycophenolate Mofetil/Mycophenolic Acid

Chapter 22. Dapsone

Chapter 23. Cyclophosphamide

Chapter 24. Tetracyclines

Part 7. Specific Management of Pemphigus. Biological Therapy

Chapter 25. Intravenous Immunoglobulins

Chapter 26. Rituximab

Chapter 27. Etanercept and Other Anti-TNF

Part 8. Additional Therapy and Monitoring

Chapter 28. Management of Pain in Pemphigus Vulgaris

Chapter 29. Extent Measures in Pemphigus

Chapter 30. Quality of Life in Pemphigus


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