Biochemistry and Molecular Biology Coming of Age


Mary Miu Yee Waye, PhD (Editor)
Professor, School of Biomedical Sciences, President, Hong Kong Society of Biochemistry and Molecular Biology, Founding Director, Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Hong Kong

Series: Biochemistry Research Trends
BISAC: SCI007000

The vast number of uncharacterized genes and proteins found in different organisms has led to an unprecedented explosion of molecular biological information. This complex information will have tremendous implications on disease diagnosis, management, and treatment. This book provides insights into the understanding of function and structure of genes and proteins, and of biochemical, cellular, and molecular signaling networks. (Imprint: Nova)


Table of Contents

Table of Contents


Biochemistry and Molecular Biology in Hong Kong: Past and Future
T. R. C. Boyde

Research Articles 1

Chapter 1 – Calpains-Mediated PTEN Cleavage in Excitotoxic Neuronal Death 3
Minghui Jessica Chen, Piang Chin Benjamin Soo, Meng Shyan Choy, Zhao Feng Peng, Heung-Chin Cheng and Nam Sang Cheung

Chapter 2 – NUDCD2 Is Overexpressed in Head and Neck Squamous Cell Carcinoma and Is Involved in Nuclear Division 19
Anne Cromer, Alberto Zambrano, Régine Millon, Joseph Abecassis and Bohdan Wasylyk

Chapter 3 – Genotype Analyses Using SNP (Using MALDI-TOF Mass Spectrometry) and STR (Microsatellite) Markers in the Determination of Zygosity Status of Chinese Twins 41
Cadmon K. B. Lim, Venus S. Y. Yeung, Tze Lun Yeung, Aaron C. Y. Tam, Connie SH Ho, Simpson W. L. Wong, Bonnie W. Y. Chow, Yee Miao Ho, Crystal Hin Ning Chou, Chi-Hang Fred Fung, Chee Fei Wong and Mary M. Y. Waye

Chapter 4 – The Dyslexia Candidate Gene Kiaa0319L Encodes N-Glycosylated Isoforms That Form Homo-Dimers 55
Ming-Wai Poon, Hoi-Ling Chan, King-Poo Lim and Mary Miu-Yee Waye

Chapter 5 – Identification of Feed Forward Loops Composed of MicroRNAs and Transcription Factors in Arabidopsis 69
Nicholas Wu, Xiaozeng Yang and Lei Li

Chapter 6 – Proteomic Profiling of 6-Hydroxydopamine-Treated Zebrafish Using iTRAQ-2D LC-MS/MS Analysis 77
Benson U. Wang Lei, Nan Yu, Zai-Jun Zhang, Edward Lau, S. O. Siu, Maggie P. Y. Lam, Guo-Hui Li, Ivan Keung Chu and Simon Ming-Yuen Lee

Chapter 7 – Using Synthetic Lethality in the Targeted Treatment of Human Cancers 101
Matthew J. Imrie, Alexandria Jack and Francis Choy

Brief Report 113

Chapter 8 – Sanfilippo Syndrome: Identification and Removal of a Cryptic Splice Site in Αlpha-N-Acetylglucosaminidase cDNA for Potential Improved Expression and Enzyme Replacement Therapy 115
Sarah N. Truelson, R. Rebecca Jantzen and Francis Y. M. Choy

Review 127

Chapter 9 – Comparisons of EEG/QEEG Normative Databases and Review of Studies of Neurofeedback for Dyslexia 129
Warwick C. L. Cheung

News 193

Chapter 10 – Conference Report of 2010 Inter-University Post-Graduate Symposium 195
Edwin Chan

Chapter 11 – Launching Theme-Based Research in Hong Kong 197
Anthony Chan

Chapter 12 – Conference Report of 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium 199
Bryan Ho, Julian Tanner and Dong-Yan Jin

Perspectives 203

Chapter 13 – Chaos Theory in Astrophysics, Nature, Genetics, and Human Cancer 205
Jessica Li

Paths to Success 213

Chapter 14 – Forget About Competition and strike for the Best 215
Masayo Kotaka

Chapter 15 – The Priceless Gift from Research and Experiments 217
Kit Ray Ng

Chapter 16 – Crave for Improvements and Step Forward 219
Ming Yuen Lee

Chapter 17 – Try Hard, and Curiosity Will Lead to Success 221
Hoi Yeung Li

Chapter 18 – Back to the Road to Research 223

Appendix: Selected Abstracts from the 2010 Inter-University Post-Graduate Symposium Held in Hong Kong 225

Index 231


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