Biliary Diseases with Pancreatic Counterparts: A New Disease Concept

Yasuni Nakanuma (Editor)
Professor Emeritus, Department of Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

Series: Pathology Research and Practices
BISAC: MED067000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Many pathologists and some clinicians notice in practical services that several biliary tract diseases resemble pathologically — and even biologically — some pancreatic diseases. In this book, the authors provide the anatomic and biological basis and characteristics for the occurrence of similar features in several diseases of the biliary tract and pancreas, and also the reasons why they propose the new disease concept known as “biliary diseases with pancreatic counterparts”.

This book provides a comprehensive overview of several representative “biliary diseases with pancreatic counterparts”, from basic understanding to practical aspects, and presents the latest advances. The contributing authors extensively discuss the topic from different perspectives, including diseases such as IgG4-related diseases involving the pancreas and biliary tract, intraductal papillary neoplasm and intraductal tubulopapillary neoplasm of the bile duct and pancreas, invasive adenocarcinoma of the pancreas and biliary tract and their precursor lesions, and alcoholic pancreatitis and adenitis of the peribiliary glands, and so on.

Biliary Diseases with Pancreatic Counterparts: A New Disease Concept is a valuable resource for clinicians in various disciplines, such as internal medicine, surgery, pathology and radiology. It allows biliary researchers and practitioners to broaden their understanding of the subject, and further explore the latest findings in clinicopathological features of these biliary tract and pancreatic diseases. (Imprint: Nova Biomedical)

Preface

Chapter 1. Proposal of a Novel Disease Concept “Biliary Diseases with Pancreatic Counterparts” Based on Unique Anatomical and Biological Characteristics of the Biliary Tree and Pancreas
Yasuni Nakanuma (Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan, and Department of Diagnostic Pathology, Fukui Saiseikai Hospital, Fukui, Japan)

Chapter 2. Pathologic Significance of Glands of Pancreatic Ducts with Reference to Peribiliary Glands
Mari Mino-Kenudson (Department of Pathology, Massachusetts General Hospital, Massachusetts, USA)

Chapter 3. IgGG4-Related Sclerosing Cholangitis and Type I Autoimmune Pancreatitis
Kenichi Harada (Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan)

Chapter 4. Peribiliary Cysts and Alcoholic Hepatic and Pancreatic Diseases
Takashi Matsubara, Yasuni Nakanuma, Kazuto Kozaka, Osamu Matsui and Toshifumi Gabata (Department of Radiology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan)

Chapter 5. Extrahepatic Cholangiocarcinoma and Pancreatic Duct Adenocarcinoma
Shinichi Aishima (Department of Pathology, Saga Medical University School of Medicine, Saga, Japan)

Chapter 6. Biliary Intraepithelial Neoplasia and Pancreatic Intraepithelial Neoplasia
Yasunori Sato (Department of Pathology, Kanazawa University School of Medicine, Kanazawa, Japan)

Chapter 7. Intraductal Papillary Neoplasms of the Bile Duct: What Is Known and What Requires Further Clarification
Yuki Fukumura, Osman Mamat, Yuka Yanai, Masaru Takase, Jinkan Sai, and Yasuni Nakanuma (Department of Human Pathology, Juntendo University, School of Medicine, Tokyo, Japan, and others)

Chapter 8. Biliary Neoplasms Arising from Peribiliary Glands
Yasuni Nakanuma (Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan, and Department of Diagnostic Pathology, Fukui Saiseikai Hospital, Fukui, Japan)

Chapter 9. Intraductal Tubulopapillary Neoplasm of the Bile Duct and Pancreas
Hiroshi Yamaguchi (Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan)

Chapter 10. Mucinous Cystic Neoplasm of the Liver and Pancreas
Motoko Sasaki (Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan)

Chapter 11. Radiological Approaches to Biliary Diseases with Pancreatic Counterparts
Kazuto Kozaka and Matsui Osamu (Department of Radiology, Kanazawa University School of Medicine, Kanazawa, Japan)

Chapter 12. Biliary Tract and Pancreatic Neoplasms with Respect to IGG4-Related Diseases
Ryo Ashida, Yasuni Nakanuma, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Yusuke Yamamoto, and Katsuhiko Uesaka (Division of Hepato-Biliary-Pancreatic Surgery, and Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan)

Editor Contact Information

Index

“In this excellent initiative, leading a pluri-institutional group of more than 20 Japanese experts in pathological , radiological, clinical and surgical aspects of diseases of the liver, biliary tree and pancreas, Professor Nakanuma unifies relevant concepts regarding major diseases of biliary and pancreatic ducts developed along decades of practice in diagnostic pathology and in anatomic and molecular research, nowadays added with major contribution from many research groups from the Eastern and Western international academic centers.
Along the 12 chapters of this rather concise text, Nakanuma and coworkers expand the bases of their rationale for understanding of biliary-pancreatic diseases. Centered on the concepts of common embryology and on the similarities of response of epithelial cells from what used to be considered two converging ductal systems to different insults and to major molecular signals driven by transcriptional factors, Nakanuma, et al. presents compelling evidences for unifying concepts, leading the reader to the presently, well accepted understanding of “biliary diseases with pancreatic counterparts.
The integration of molecular and histopathological approaches pave the way to this unified concept of biliary-pancreatic system, is further based on the demonstration of important similarities of peribiliary glands and pancreatic duct glands, serving as sources for common progenitor cells , key structures in the pathogenesis both of inflammatory and of neoplastic biliary-pancreatic diseases.
This book is richly illustrated by macroscopic specimens, by histopathological and immune-histochemical images, complemented, whenever adequate, by radiological aspects, driving the reader along major pathological conditions that affect the biliary-pancreatic tree.
Based on these comments, I strongly recommend this book to pathologists, radiologists, endoscopists, clinicians and surgeons devoted to the study of the diseases of the liver, biliary ducts and pancreas.” - Venancio Avancini Ferreira Alves, MD, PhD, Professor and Chairman, Department of Pathology, University of Sao Paulo School of Medicine,Sao Paulo, Brazil

Audience: Hepatobiliary, pancreatic and gastrointestinal physicians, particularly surgeons, internists, radiologists and pathologists, Institusions devoted to therapeutical and imagings developments for hepatobiliary pancreatic diseases, Tutors and educational peoples in pathology, physiology and clinical medicine

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