Bicuspid Aortic Valve: Diagnosis, Surgical Treatment and Complications


Anthony Chapman (Editor)

Series: Congenital Disorders – Laboratory and Clinical Research
BISAC: MED107000

Bicuspid aortic valve (BAV) is the most common congenital pathology of the aortic valve occurring in 0.5-2% of the general population and frequently requiring surgical management after the fourth decade of life. From the etiology to the surgical management of BAV is analyzed. Other chapters review genome-wide association studies, linkage analyses and next-generation sequencing studies, which are beginning to build a more comprehensive picture of the genetic bases of BAV. The prospects for developing tools for genetic screening of families and for risk stratification are explored as well, including the future steps which are necessary for the creation of an individualized approach to managing BAV. The last chapter is a review of the present understanding of ascending thoracic aortic aneurysm pathogenesis. The genetic basis and basic pathology underlying BAV and ascending thoracic aortic aneurysms are discussed as well, and are compared to known mechanisms underlying other aortopathologies. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Bicuspid Aortic Valve Syndrome: From the Etiology to the Surgical Strategies of Treatment
(Paolo Nardi, Marco Russo, Antonio Pellegrino, and Luigi Chiariello, Policlinico Universitario Tor Vergata, Tor Vergata University of Rome, Rome, Italy)

Genetic Influences on Phenotype in Bicuspid Aortic Valve: Screening, Diagnosis and Prognosis
(Catherine Francis and John Pepper, NIHR Cardiovascular BRU, Royal Brompton Hospital; National Heart & Lung Institute, Imperial College London and Institute of Cardiovascular Medicine and Science, London/Liverpool, England)

Genetic Basis, Pathogenesis and Histopathology of Aortopathy in Bicuspid Aortic Valve and Marfan Syndrome
(Junfeng Yan<sup>a</sup>, Ann-Cathrin Lehsau<sup>a</sup>, Pamela Lazar-Karsten<sup>a</sup>, Detlev Schult-Badusche<sup>a</sup>, Luc Mertens<sup>b</sup>, Bart L. Loeys<sup>c</sup>, Salah A. Mohamed<sup>a</sup>, <sup>a</sup>Department of Cardiac and Thoracic Vascular Surgery, UK SH-Campus Luebeck, Luebeck, Germany; <sup>b</sup>The Hospital for Sick Children, Toronto, Candada; <sup>c</sup>Center of Medical Genetics, University of Antwerp and University Hospital of Antwerp, Belgium, Radhoud University, Nijmegen, The Netherlands)


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