Table of Contents

ABSTRACT

Hypercholesterolemia and inflammation are biological risk factors for CVDs and, in the absence of treatment, contribute equally to the risk of atherosclerosis. There is evidence that patients at risk of atherosclerosis are treated with statins to decrease blood cholesterol, inflammation, and adjunct therapies are used for further decrease in the risk of CVDs. It is possible that further reduction of cholesterol and target inflammation with adjunct therapy may be more rewarding. It seems that inflammation contributes more to the risk of CVDs compared to residual cholesterol does and could be targeted with adjunct therapy among patients receiving statins.

Keywords: Cytokines, inflammation, atherogenic, thrombosis