Beta-Catenin: Structure, Function and Clinical Significance


Abel Braunfeld (Editor)
Gabriel R. Mirsky (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

β-catenin is a multifunctional protein required in both cell-cell adherens junctions and canonical Wnt signalling. It is involved in a variety of developmental processes and is critical in heart development, one of the first functional organs to develop during vertebrate embryogenesis. In this book, the authors discuss the structure, function and clinical significance of β-catenin.

Topics include the role of β-Catenin in the context of oral squamous cell carcinoma and its clinical implications; how β-Catenin/TCF4/Survivin signaling determines the properties and fate of human corneal epithelial stem cells; β-Catenin in kidney fibrosis and cardiovascular development; the role of β-Catenin in eye development, infection and inflammation; and the clinical significance of Beta-Catenin in immunological disease and dysfunction. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


The Role of β-Catenin in the Context of Oral Squamous Cell Carcinoma and its Clinical Implications
(Marilia Ferreira Andrade, Adriano Mota Loyola, Marcelo José Barbosa Silva, Alberto da Silva Moraes, Flávia Sayuri Matsuo, Sérgio Vitorino Cardoso, João Paulo Silva Servato, Felipe Andrés Cordero da Luz, Paulo Rogério de Faria, Department of Morphology, Laboratory of Histology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais State, Brazil, and others)
Free Download Available

β-Catenin/TCF4/Survivin Signaling Determine the Properties and Fate of Human Corneal Epithelial Stem Cells
(De-Quan Li, David Hui-Kang Ma, Rong Lu, Fang Bian, Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology and Center for Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX, USA, and others)

β-Catenin and Kidney Fibrosis
(Xinrui Tian, Yanting Dong, Jianlin Zhang, Hailong Wang, Jun Xie, Bo Niu, David Harris, Guoping Zheng,Department of Respiratory Medicine, The Second Hospital of Shanxi Medical University, Taiyuan Shanxi, China, and others)

Beta-Catenin and Cardiovascular Development
(Elaine O’Connor, Miriam Moriarty, Maura Grealy, Pharmacology and Therapeutics, School of Medicine, NUI Galway, Galway, Republic of Ireland)

The Role of β-Catenin in Eye Development
(Naoko Fujimura, Zbynek Kozmik, Department of Transcriptional Regulation, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska, Prague, Czech Republic)
Free Download Available

The Novel Roles of Beta-Catenin in Infection and Inflammation
(Jun Sun, Yong-guo Zhang, Rong Lu, Yuanyuan Zheng, Shaoping Wu, Department of Biochemistry; Rush University Medical Center, Chicago, IL USA)

Clinical Significance of Beta-Catenin in Immunological Disease and Dysfunction: Signaling and Therapy
(Tze Wei Poh, Sandra J. Gendler, Departments of Immunology and Biochemistry/Molecular Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ, USA)
Free Download Available



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