Benzofuran: Production and Applications

$160.00

Murilo Souza Barros (Editor)

Series: Chemistry Research and Applications
BISAC: SCI013040

Benzofurans have garnered the attention of medicinal chemists due to their broad pharmacological activity. Benzofuran: Production and Applications provides insight into the natural origin of these compounds, reported biological activities for various analogs, synthetic routes to obtain benzofurans substituted at different heterocycle sites, and controlled release encapsulation methods.

Dihydrobenzofuran neolignans are secondary metabolites arising from the coupling of two phenylpropanoid units during the shikimate biossynthetic pathway. In this compilation, the natural sources and synthetic routes from which dihydrobenzofuran neolignans can be obtained are reviewed, and their biological potential is highlighted.

Additionally, the authors focus on the palladium and rhodium catalyzed multiple C-H functionalizations in the synthesis of benzofurans and their derivatives. The use of Ir and Ru salts is also explored.

A review of the aspects related to cancer initiation and progress, as well as the applications of benzofurans as structural frameworks for the development of new drugs against cancer, is provided.
(Imprint: Nova)

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Table of Contents

Preface

Chapter 1. Origins and Biological Applications of Benzofurans
(Jorddy Neves Cruz, Sebastião Gomes Silva, Jose de Arimateia Rodrigues do Rego, Joyce Karen Lima Vale, Fernanda Wariss Figueiredo Bezerra, Wanessa Almeida da Costa, Davi do Socorro Barros Brasil, Cleydson Breno Rodrigues dos Santos, Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade, Botany Coordinating, Paraense Emilio Goeldi Museum, Belém, PA, Brazil, and others)

Chapter 2. Dihydrobenzofuran Neolignans: An Overview of Their Chemistry and Biological Activities
(Herbert J. Dias, Eliane O. Silva, Tatiana M. Vieira and Antônio E. M. Crotti, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil, and others)

Chapter 3. Palladium or Rhodium Catalyzed Benzofuran and Derivatives Synthesis via C-H Functionalizations
(Bo. Sun, PhD, Tian-Yu. Yao, MD, Lu-Lu. Zhang, MD, Ming-Li, PhD, Lin-Bao. Zhang, PhD, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China)

Chapter 4. Benzofurans Scaffolds: Applications in Anticancer Drugs Discovery and Development
(Jorddy Neves Cruz, Kauê Santana da Costa, Marcia Moraes Cascaes, Fernanda Wariss Figueiredo Bezerra, Ingryd Nayara de Farias Ramos, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade and Cleydson Breno Rodrigues dos Santos, Botany Coordinating, Paraense Emilio Goeldi Museum, Belém, PA, Brazil, and others)

Index

Additional information

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