Benzimidazole: Preparation and Applications

Aksel A. Vestergaard (Editor)

Series: Chemistry Research and Applications
BISAC: SCI013040

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Benzimidazole: Preparation and Applications first defines the structure, physical and chemical properties of the benzimidazole compound class. Further conventional and alternative synthesis methods and important reactions of these compound derivatives are illustrated with examples.

The authors provide an overview of benzimidazole-based synthetic medicine and their significant applications in treating various ailments. The chemical reactions of benzimidazole with other heterocyclic compounds/chemical reagents produce a lot of new substituted molecules, which have potential pharmaceutical applications.

A literature review is presented focusing on the synthesis of chiral compounds and their subsequent applications as therapeutic compounds in order to better evaluate the results so far.

Additionally, the authors discuss how nenzimidazole derivatives play a vital role in organic light emitting diodes as emissive materials, host materials, electron transport materials, hole blocking materials, etc., and have pharmaceutical applications such as antimicrobial, antihypertensive, anti-HIV and anticancer.

Following this, this collection examines classes of potential chemosensors possessing benzimidazole moieties which are capable of both visual and optical estimation of target analytes over a broad concentration range and without interference of contemporary analytes.

Important methodologies used for the synthesis of variedly substituted benzimidazoles are presented along with their multi-target therapeutic uses.

The latest research on anti-tumor and antimicrobial benzimidazole compounds, as well as structure-activity correlations, drug design, clinical and preclinical studies is also presented.

Benzimidazole-based polymers with various architecture and copolymers are discussed with a variation of properties such as mechanical, thermal stability, thermo-oxidative stability and enhanced performance.

The penultimate chapter covers a critical analysis of the recent developments in benzimidazole framework research and the future scope of benzimidazole framework in ligand designing.

In closing, the synthesis and biological properties of coordination compounds containing benzimidazole derivatives are presented and discussed.
(Imprint: Nova)

Preface

Chapter 1. Overview of Benzimidazole Compound Class
(Bahittin Kahveci, PhD, and İnci Selin Doğan, PhD, Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey, and Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey)

Chapter 2. Chemistry and Medicinal Importance of Benzimidazole
(Mohammad Rashid and Asif Husain, Department of Medicinal Chemistry and Pharmacognosy, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Al-Qassim, Kingdom of Saudi Arabia, and Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India)

Chapter 3. Chiral Benzimidazoles in Medicinal Chemistry: Syntheses and Applications
(Maria Marinescu, Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, Bucharest, Romania)

Chapter 4. Benzimidazole Preparation and Applications: Benzimidazole Derivatives in Organic Light Emitting Device
(J. Jayabharathi PhD and V. Thanikachalam PhD, Department of Chemistry, Material Science Lab, Annamalai University, Annamalainagar, Tamilnadu, India)

Chapter 5. Charged Guest Stimulated Benzimidazole Based Chemosensors
(Gargi Dhaka, PhD, and Navneet Kaur, PhD, Department of Chemistry, Panjab University, Chandigarh, India)

Chapter 6. Multifunctional Compounds: A New Journey of Benzimidazole
(Richa Minhas, Ankit Singhal, Gulshan Bansal and Yogita Bansal, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India)

Chapter 7. Benzimidazole Compounds with Anti-Tumor and Antibacterial Activities
(Christina-Marie Zalaru and Maria Marinescu, Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, Bucharest, Romania)

Chapter 8. Synthesis of Benzimidazole Based Polymeric Film for Application in Fuel Cell
(Asit Baran Samui, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, India)

Chapter 9. Substituted Benzimidazoles as Ligands: Recent Developments in Designing and Applications
(Aayushi Arora, Preeti Oswal, Gyandshwar Kumar Rao, Arun Kumar, and Ajai Kumar Singh, Department of Chemistry, School of Physical Sciences, Doon University, Dehradun, Uttarakhand, India, and others)

Chapter 10. Benzimidazole Derivatives: Chelating Properties Towards Transition Metals Ions and Their Applications
(Karim Chkirate and El Mokhtar Essassi, Laboratory of Heterocyclic Organic Chemistry, Pole of Competence Pharmacochemistry, Mohammed V University, Faculty of Sciences, Av Ibn Battouta, BP, Rabat, Morocco)

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