Behçet’s Disease: Progress in Recent Years and Unmet Needs for the Future

Shunsei Hirohata, MD (Editor)
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan

Series: Immunology and Immune System Disorders
BISAC: MED044000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Behçet’s disease is a chronic relapsing inflammatory disease of unknown etiology involving multiple organs. Along with blindness, other bodily functions are greatly affected by this disease; conditions of the vascular, intestinal and central nervous systems are usually life threatening and require aggressive therapy. Recently, significant progress has been made in several areas of this disease. The introduction of biological agents (such as anti-TNF) have had a positive impact on the effectiveness of treatments.

However, there are still a number of unmet needs in various fields of this disease. Despite this, there remains a number of unaddressed issues concerning the treatments of this disease. Several genes have been shown to be associated with this disease, in addition to HLA-B51. Abnormalities in several subsets of T helper cells have been implicated in the pathogenesis of Behçet’s disease. Recent advances in the field of innate immunity have shed light on the new aspects of Behçet’s disease; that is, this disease has both autoimmunity and autoinflammatory aspects. On the other hand, there are still controversies as to the diagnosis and treatment of recalcitrant manifestations of the disease.

This publication highlights the most recent understanding of Behçet’s disease and raises several unanswered questions in both basic to clinical treatment of this ailment. The contents of this book are primarily based on the most up-to-date results of research programs sponsored by the Japanese government as well as findings from Korean researchers. In particular, novel classification for neurological involvement (which has been discovered in Japan) led to the establishment of diagnostic criteria and treatment recommendation. Thus, this publication brings forth useful information for a variety of specialists who are involved in the management of this intractable disease.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Overview
(Shunsei Hirohata, Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan)

Chapter 2
Genetics of Behcet’s Disease
(Eun Ha Kang, Yeong Wook Song, Division of Rheumatology, Department of Internal Medicine, Seoul National University, Bundang Hospital, Seoul, South Korea, and others)

Chapter 3
Immunological Abnormalities
(Hidekata Yasuoka, Masataka Kuwana, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, and others)

Chapter 4
Behçet’s disease from an innate immune perspective
(Hajime Kono, Kurumi Asako, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi, Tokyo, Japan)

Chapter 5
Pathological characteristics
(Shunsei Hirohata, Hirotoshi Kikuchi, Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine
Sagamihara, Kanagawa, Japan, and others)

Chapter 6
Mucocutaneous involvement
(Do Young Kim, Zheng Zhenlong, Sungwon Suh, Dongsik Bang, Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea)

Chapter 7
Eye involvement
(Toshikatsu Kaburaki, Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan)

Chapter 8
Joint involvement
(Yuki Nanke, Shigeru Kotake, Institute of Rheumatology, Tokyo Women’s Medical University, Kawada-cho, Shinjuku-ku, Tokyo, Japan)

Chapter 9
Intestinal involvement
(Hirotoshi Kikuchi, Shunsei Hirohata, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, and others)

Chapter 10
Neurological involvement
(Shunsei Hirohata, Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan)

Chapter 11
Vascular involvement
(Hirotoshi Kikuchi, Shunsei Hirohata, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, and others)

Chapter 12
Prognosis and treatment
(Tetsuji Sawada, Department of Rheumatology, Tokyo Medical University Hospital, Tokyo, Japan)

Index

Audience: Rheumatologists, Immunologists, Pathologists, Gastroenterologists, Cardiologists, Dermatologists, Opthalmologists, Neurologists, General Physician, Nurses, Physical Therapists

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