Behavioral Study of Agonist-Evoked Activation of Transient Receptor Potential Channels


Merab G. Tsagareli, PhD, DScHead, Lab of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia

Series: Pain Management – Research and Technology
BISAC: MED093000

This book provides an original account of behavioral aspects with important ramifications for the study of transient receptor potential (TRP) channels functioning. It explains, in terms of specified somato-sensory mechanisms and systems, how TRP channels work. Through exploration of animal models by testing paw withdrawal reflexes to thermal and mechanical stimuli, it is shown that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents



Chapter 1. Introduction

Chapter 2. Phylogeny of TRP Channels

Chapter 3. Structural-Functional Characteristics of TRP Channels

Chapter 4. A Short Review of TRP Superfamily

Chapter 5. Thermo-TRP Channels

Chapter 6. TRP Channels in Physiological Nociception and Pain

Chapter 7. TRP Channels as Therapeutic and Analgesic Targets

Chapter 8. TRP Channels and NSAIDs

Chapter 9. Concluding Remarks and Perspectives



Keywords: Pain, TRP channels, nociception, anti-nociception, hyperalgesia, allodynia, analgesia

Audience: Pain and itch medicine; pharmacology and drug discovery

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