Bacillus subtilis: Morphology, Functions and Role in Disease Management

Angelo Curtis (Editor)

Series: Microbiology Research Advances
BISAC: SCI006000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Bacillus subtilis is a motile gram-positive bacterium widespread in the soil and the gut of animals which has been reported to cause opportunistic infections in immunocompromised patients. In Bacillus subtilis: Morphology, Functions and Role in Disease Management, the authors begin by outlining the main features of chemotaxis as a behaviour, then reviewing the molecular machinery Bacillus subtilis uses to sense and respond to chemical cues.

Following this, the authors discuss how bacterial biofilms can form on biotic and abiotic surfaces, developing various reversible and irreversible stages depending on environmental conditions. An important characteristic of biofilm is the extracellular matrix, which is usually formed by exopolysaccharide and extracellular proteins by Bacillus subtilis.

Next, this compilation highlights the key features in Bacillus subtilis lipopeptides as eco-friendly controllers of plant pathogens. Currently, phytopathogens impact all agricultural systems, leading to economic losses worldwide.

The closing chapter discusses NKCP®, a novel dietary supplement derived from traditional Japanese traditional food, which improved patients’ symptoms and blood pressure by improving blood flow through antithrombotic and fibrinolytic properties.


Chapter 1. Chemotaxis in Bacillus subtilis: From Molecular Reactions to Population-Level Behaviours
(Rose E. K. Rae and Filippo Menolascina, School of Engineering, Institute For Bioengineering, University of Edinburgh, Edinburgh, UK)

Chapter 2. Biofilm Formation by Bacillus subtilis
(Daniela Ionela Istrati and Oana Emilia Constantin, Department of Food Science and Engineering, Biotechnology and Aquaculture, Faculty of Food Science and Engineering, Dunãrea de Jos University of Galați, Galați, România)

Chapter 3. Bacillus subtilis Lipopeptides: Future Eco-Friendly Controllers of Plant Diseases
(Cristiano José de Andrade, Lidiane Maria de Andrade, Sidnei Emilio Bordignon, Ana Elizabeth Cavalcante Fai, Camilla Pires, Ana Paula Resende Simiqueli, Aline Wasem Zanotto, Jorge Alberto Soares Tenório, Débora de Oliveira and Gláucia Maria Pastore, Technological Center, Chemical Engineering and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, SC, Brazil)

Chapter 4. How a Novel Protease Produced by Bacillus subtilis natto Improves Blood Flow: Subjective Symptoms in Lifestyle-Associated Disease
(Masahito Hitosugi, MD, PhD, Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan)
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