Autoimmunity versus Carcinogenesis in Tissue Injury


Lawrence M. Agius, PhD (Author) – Senior Lecturer in pathology, Consultant in histopathology and neuropathology (retired) University of Malta Medical School, Mater Dei Hospital Malta

Series: Immunology and Immune System Disorders

BISAC: MED044000

Target Audience: This book is aimed particularly to researchers involved in tumorigenesis and the understanding of mechanistic attributes of malignant transformation.

This book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for.




Chapter 1. Predetermined Interplay of the Projected Malignant Transformation Step as Injury Non-Resolution

Chapter 2. Systems of Active Immune Suppression as Integral Malignant Transformation in Infiltrating Glioma Cells

Chapter 3. Systems of Failure of Immune Response to Early Carcinogenesis Recharacterize Such Early Carcinogenesis

Chapter 4. Mirror Images of Geometric Pre-Setting of the Infiltrating Edges of High-Grade Gliomas

Chapter 5. Failed Tumor Immuno-Antigenicity Is Expressed Suppression of an Autoimmunity in Defining Immune Privilege Status of the Lesion

Chapter 6. Complex Effectiveness of General Immunity in Modulating the Specific Immune Response in Gliomas

Chapter 7. Systems of Malignant Transformation as Integral Immune Nonresponse in Gliomagenesis

Chapter 8. Immunodominance as Complex Patterned Interplay of Antigen Quantitation Phenomena in Pressure Immunity

Chapter 9. Systems of Unstable Immunodominance of Antigen as Formulas for Central Immunosuppression in Tumor Cell Expansion

Chapter 10. Failed Immunosurveillance as Failed Dendritic Cell Antigen Presentation—Substitution of Specific Tumor Antigenicity by Differentiation Associated Antigenicity

Chapter 11. Projected Receptivity of Integral Gliomas to Malignant Transformation as Modeled by Dysfunctional Immunomodulation

Chapter 12. Tumor Cell Identity as Projected by Immunotoxins within Heterogeneity and Hierarchical Systems of Progression

Chapter 13. Dimensions of Reproducible Malignant Transformation as Brain Infiltration by Glioma

Chapter 14. Infiltrativeness Attributes Project Schemes of Etiology and Pathogenesis in Sequential Malignant Transformations in Given Individual

Chapter 15. Progressively Persistent Tumor Cell Growth and Recurrence and Spread as Interplay Dynamics between Individual Neoplastic Cells

Chapter 16. Non-Response of the Immune System as Active Participant in Glioma Cell Genesis, Proliferation, and Spread in Normal Brain Tissues

Chapter 17. Pathways of Non-Resolution in Targeting Tumor Cells by the Immune Response

Chapter 18. Tumor Cell Antigenicity as Performance Hierarchy of Equilibrating Interactivity of Systems of Receptivity and Activation of Lymphocyte Subsets

Chapter 19. Systems of Primary Regional Reformation in Tumor Origin and Mechanics: Regional versus Field Operability

Chapter 20. Formulation of an Integral Antitumor Immune Response

Chapter 21. Systems of Weak Immunogenicity as Originators of Early Spread and of Incremental Tumor Cell Growth and Proliferation


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